Báo cáo y học: " APOBEC3G targets human T-cell leukemia virus type 1" docx
Báo cáo Y học: Structure of human immunodeficiency virus type 1 Vpr(34–51) peptide in micelle containing aqueous solution pptx
... incorporation of Vpr.Keywords: HIV-1; Vpr; solution structure; dodecylphos-phocholine micelles; NMR. Human immunodeficiency virus type 1 (HIV-1) is a memberof the lentivirus family. In addition to ... Ju¨lich, IBI-2, Germany Human immunodeficiency virus type 1 protein R (HIV-1Vpr) promotes nuclear entry of viral nucleic acids innondividing cells, causes G2cell cycle arrest and isinvolved ... simian immunodeficiency virus encodes avirion-associated protein. J. Virol. 64, 5688–5693.5. Lu, Y. L., Spearman, P. & Ratner, L. (1993) Human immunodeficiency virus type 1 viral protein R....
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Báo cáo y học: " APOBEC3G targets human T-cell leukemia virus type 1" docx
... activity of APOBEC3G on human T-cell leukemia virus type 1 (HTLV-1), the first identified human retrovirus.Results: In this study, we have demonstrated that overexpressed as well as endogenous APOBEC3G ... enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity. It inhibits infectivitiy of a widevariety of retroviruses by deaminating deoxycytidine ... purposes)RetrovirologyOpen AccessResearch APOBEC3G targets human T-cell leukemia virus type 1Amane Sasada1, Akifumi Takaori-Kondo*1, Kotaro Shirakawa1, Masayuki Kobayashi1, Aierkin Abudu1,...
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Báo cáo y học: "Acute lymphocytic crisis following herpes simplex type 1 virus hepatitis in a nonimmunocompromised man: a case report" pptx
... virus (EBV), cytomegalovirus (CMV), herpes virus zoster, toxoplasma, coxsackie, mycoplasma pneu-moniae, hepatitis B virus, hepatitis A virus, adenovirus,echo virus, human immunodeficiency virus ... and the human immunodeficiency virus (HIV-1).Other infections have been implicated as occasionaletiologies of the mononucleosis syndrome, including human herpes virus type 6, adenovirus type 12 ... non-immunocompromised patientpresenting with atypical acute lymphocytic syndrome.AbbreviationsALL, acute lymphoblastic leukemia; CLL, chronic lym-phocytic leukemia; CMV, cytomegalovirus; CRP, C-reac-tive protein;...
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Báo cáo y học: "Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis" ppt
... Increased peptidylarginine deiminase type II in hypoxic astrocytes. Biochem Biophys Res Commun 2004, 325:1324-1329.70. Ishigami A, Ohsawa T, Hiratsuka M, Taguchi H, Kobayashi S, Saito Y, Murayama S, ... therapeutic use of tetracyclines in RA [23], Knuckley and colleagues [28] screened tetra-cycline derivatives (minocycline, doxycycline, tetracy-cline, and chlortetracycline) for their potential ... post-translational conversion is catalyzed by the family of peptidylarginine deiminase (PAD) enzymes. e process of protein citrullination plays a vital role in normal physiology, in which it is involved...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... applying them therapeutically [5, 6]. Type 2 diabetes is characterized by insulin re-sistance and insulin secretion deficiency. At present, there is no a single medication which treats type ... for type 2 diabetes [3, 12]. However, the clinical application of native GLP-1 is hampered by its very short plasma half-life [5, 6, 13]. This is due to its rapid inactivation by dipeptidyl ... activity than full-length adiponectin. We selected gAd as the con-jugating molecule of GLP-1 in our study. This design not only may prevent the renal filtration of GLP-1, but also may yield...
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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"
... fragility of loaded erythrocyte at 2, 4, 8 mg/ml pravastatin when com-pared to that of unloaded erythrocytes (Table 4). Table 4, Erythrocyte osmotic fragility of unloaded eryth-rocytes and erythrocytes ... loaded erythrocytes Hematological Indices To determine the effect of loading process on erythrocytes, normal erythrocytes, erythrocytes sus-pended in PBS, and pravastatin-loaded erythrocytes ... Watanabe M, Sekine S, Yanagida Y, Kobayashi S. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibi-tor, in rats and healthy human subjects....
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Báo cáo Y học: Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification pdf
... Choi, Y. H., Sung, B.J., Shin, N.G., Shin,H C., Sung, Y. C. & Oh, B H. (1999a) 2.8 A˚resolution crystalstructure of human TRAIL, a cytokine with selective antitumoractivity. Immunity 11, ... family. Recently, thecrystal structure of human TRAIL showed that TRAIL is ahomotrimeric protein whose subunits contain mainlyb-sheets. We characterized the structural changes ofrecombinant human ... observed in such structurally and evolutio-narily related cytokines as TNF-a and LT.TRAIL in its native state consists mostly of b-sheets.When it was partially unfolded by acidification, it inducedan...
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Báo cáo Y học: Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17–21 for the oligomerization state and bioactivity of hCt ppt
... N,N¢-diisopropylethylamine; DMS, dimethylsulfide; EDT,ethanedithiol; hCt, human calcitonin; MBHA, 4-methyl benzhydryl-amine resin; Mtt, 4-methyltrityl; Pip, 2-phenylisopropyl;OFm, fluoren-9-yl methylester; sCt, salmon ... in vivo hypocalcemic potencies were assessed.The novel analogues include cyclo17,21-[Asp17,D-Phe19,Lys21]hCt (2), cyclo17,21-[Asp17,Aib18,Lys21]hCt (3),cyclo17,21-[Asp17,D-Lys18,Lys21]hCt ... 836–847]. We havehypothesized that a possibly type I b turn/b sheet confor-mation in the region 1 7–21 may play an important role inhCt bioactivity. To investigate this hypothesis, analogues...
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Báo cáo y học: "The proliferative human monocyte subpopulation contains osteoclast precursors" ppt
... cytokine-free, serum-free system. J Immunol Methods1992, 153:201-212.23. Cheung DL, Hamilton JA: Regulation of human monocyte DNAsynthesis by colony-stimulating factors, cytokines, and cyclicadenosine ... GM-CSF on human monocyteDNA synthesis and CSF receptor expression. J InterferonCytokine Res 1999, 19:417-423.22. Bennett S, Por SB, Stanley ER, Breit SN: Monocyte proliferationin a cytokine-free, ... Takahashi N, Yamaguchi K, Yasuda H,Shima N, Morinaga T, Toyama Y, Yabe Y, Higashio K, Suda T:Osteoclast differentiation factor (ODF) induces osteoclast-likecell formation in human peripheral...
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Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... restoration of proteoglycan synthesis by human OAchondrocytes. IGFBPs secreted by human OA cartilage orcultured chondrocytes were analyzed by western ligand blot.The ability of NBI-31772 to displace ... ineffective in promoting proteoglycan synthesisby chondrocytes. By contrast, 2.7 nM R3 IGF-1 significantlystimulated total proteoglycan synthesis, by 45% over thatby unstimulated cells. Since ... captured by autoradiography onBiomax MS films (Eastman Kodak Co, Rochester, NY,USA).Measurement of proteoglycan synthesis by rabbit chondrocytes or human OA chondrocytesChondrocytes grown...
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