Báo cáo y học: "The discovery of the first human retrovirus: HTLV-1 and HTLV-2" doc

... progression of cancer; and the second question is whether the PR domain alone possesses anticancer activity. In this study, we quan- titatively analyzed the mRNA expression level of RIZ1 over the ... (Rockville, Maryland, USA) has been reported previously [21]. Briefly, the primers and the TaqMan probe for gene RIZ encoding RIZ1 were designed and synthesized by Appl...

Ngày tải lên: 25/10/2012, 11:15

... During the therapeutic process, real-time estimation of the therapeutic effect was carried out by the computer system through the graphic changes in the target field and the hyperecho of the ... consisting primarily of lymphocytes and monocytes sometimes with small number of eosinocytes, were seen between the necrotic and normal zones. In addi- tion, hyperp...

Ngày tải lên: 25/10/2012, 11:18

... as the high- affinity peak of wild-type LPL. The LPL in the eluate was detected by Western blot with LPL polyclonal antibody 7640. The fraction number of the high-affinity peak was the same for the ... structure of monomeric LPL was duplicated and superimposed on the crystal structure of the horse PL dimer. After the energy minimization by setting at iteration of...

Ngày tải lên: 21/02/2014, 15:20

... used. RESULTS The enzymatic activity and molecular stability of the mutants The catalytic activity and the molecular stability of the mutants were assayed because a change in either of these parameters ... alignment of the interdomain and autolysis loops of mammalian chymotrypsins and trypsins. The enzyme that was used in this study, rat chymotrypsin B, is high...

Ngày tải lên: 22/02/2014, 07:20

... fits to the set of distances. The main advantages of the procedure are simple: the details of the calibration are precisely and unambiguously defined, it is fully automatic, and the family of calculated ... found. Several of these were identified in previous studies of EGF, and the backbone fold of the chimera is clearly similar to those of the EGF structu...

Ngày tải lên: 22/02/2014, 07:20

... other, indicating a substantial perturbation of the axial symmetry of the tensor, whereas axial symmetry, i.e. g xx % g yy << g zz is typically found for type 2 sites. The grouping of the g-values ... simulation. Remarkable are the large hyperfine couplings A xx and A yy , and the ordering of the g values, both of which differ from those expected for type 2 co...

Ngày tải lên: 22/02/2014, 07:20

... way to explore the nature of the binding site and the process of catalysis for a-amylases. Although the overall structure and the tertiary folding of the polypeptide chains of different a-amylases ... stable and is not hydrolysed by a-amylases therefore, the products of hydrolysis are always b-glycosides. Selection of these glycosides as substrates has been bas...

Ngày tải lên: 08/03/2014, 09:20

... version of CCR5 was present on the surface of transfected cells, and had the expected molecular mass. To test whether the presence of the myc-his tag at the C-terminus of CCR5 would interfere with the ... the C-terminus of the receptor which is located on the inside of the cell, we then determined if signal transduction by the protein was affected by this m...

Ngày tải lên: 08/03/2014, 09:20

... is the finding that the sequences of the C-terminal part of Ab-(1–42) and that of HA_fd share indeed a high similarity (Fig. 6C) dictated essentially by the presence of similarly spaced glycine residues, ... APP within the Ab sequence, and its products are not neurotoxic. Alternatively, APP can be hydrolyzed by the b secretase activity at the N-terminus of Ab, which...

Ngày tải lên: 08/03/2014, 09:20

... relationship between N-acetylation and the chymotrypsin-like activity of 20S proteasome. In the present s tudy, we detec ted the N-acetylation of OsRpt6 in the rice RP complex by MS. Other N-terminal modifica- tions ... modifications of the rice RP; N-myris- toylation of OsRpt2 and N-acetylation of OsRtp6, as determined by MS analysis (Fig. 4 and T able 3). Rpt2 from v...

Ngày tải lên: 08/03/2014, 16:20