Báo cáo y học: "Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites" pdf
Báo cáo y học: "Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites" pdf
... modifications strongly enhanced the in vivo inhibitory activity of all the antisense constructs and some of the DNAzymes. Notably, two of the LNA modified antisense oligonucleotides inhibited HIV-1 production ... sequence with DNAzymes and modified LNAzymes optimized for binding We wanted to investigate whether the selected regions in the HIV-1 leader were...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx
... of Bioscience and Biotechnology, Faculty of Engineering, Graduate School of Natural Science and Technology, Okayama University, Japan; 2 Department of Biology, Faculty of Sciences, University ... intrathecally into rabbits [18,19], and is cytotoxic to tracheal epithelium [20,21]. Although the mechanism o f its cytotoxicity is not completely understood, it is suggested to b...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: " Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome" pps
... mutant R1 may lack target sequences for trans -inhibition by AS19. Mechanism of trans -inhibition by HIV-lhNef and the AS variants We have previously described strong inhibition of HIV-1 by RNAi-inducing ... http://www.retrovirology.com/content/4/1/15 Page 11 of 14 (page number not for citation purposes) Test of sequence-specificity of the inhibition by HIV-lhNefF...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: "Reduced rates of primary joint replacement for osteoarthritis in Italian and Greek migrants to Australia: the Melbourne Collaborative Cohort Study" doc
... exposures and to increase genetic variation. The study protocol was approved by the Human Research Ethics Committee of The Cancer Council Victoria. Follow-up was conducted by record linkage to electoral ... books, the Victorian Cancer Registry, and death records. To update lifestyle exposures, the cohort was followed up with by mailed questionnaire and (as necessary) by...
Ngày tải lên: 09/08/2014, 14:21
Báo cáo y học: " Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in viv" pdf
... analysis and cells analysed by flow cytometry. Serum was prepared by cardiac puncture. Sera and lavage supernatants were assayed without delay or storage. Flow Cytometry Phenotypic analysis of ... specificity of locus degradation is guided by the antisense strand of the unwound siRNA, followed by sense strand siRNA binding to the complementary mRNA site for cleavage b...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... other inflammatory mediators produced by macrophages, and indirectly of inflammatory mediators by other cells induced by TNF-α stimulation. Here we investigate the effects of RWJ 67657, a p38 MAPK inhibitor, ... characterized by increased expression and transcription of interleukin (IL)-1β and tumor necrosis factor α (TNF-α), but also of other proin- flammatory and r...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... pathway of non -modified virus is exclusively CAR- dependent. On the other hand, the transduction of HUVECs by AddnIκB-PEG-RGD was significantly inhibited by the pres- ence of RGD-protein but not by ... (RT)- PCR and flow cytometric analysis of pro-inflammatory and pro- angiogenic gene expression profiles in tumor necrosis factor (TNF)-α activated endothelial cells. Mater...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot
... δ-(3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-methoxy-4-hydroxy-phenyl)-γ-valerolactone exhibited inhibitory activity on LPS-induced secretion of matrix metalloproteinase 9 (MMP-9) from human mono- cytes ... urine, δ-(3,4-dihydroxy-phenyl)-γ-valerolactone and δ-(3-meth- oxy-4-hydroxy-phenyl)-γ-valerolactone [10]. Valerolac- tone derivatives were also found after ingestion of green...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... (both directly and via inflammatory cells), excitotoxicity, and expression of the death receptor family members in a vari- ety of cells [10-12]. Many of these activities have been studied relative to the ... activity of lysophosphatidylcholine by direct binding. Prostaglandins and Other Lipid Mediators 2007, 83:130-138. 59. Portman OW, Illingworth DR: Lysolecithin bindin...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
... Zeng Z, Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T: Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences. Acta Biochim Biophys Sin 2009, 41:389-398. 21. ... T, Liu F: Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external guide sequence RNA. RNA 2006, 12:63...
Ngày tải lên: 12/08/2014, 04:20