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Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx

Báo cáo y học:

Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx

... purposes)Kinetics of K70E and K65R RT mutants during tenofovir therapyFigure 6Kinetics of K70E and K65R RT mutants during tenofovir therapy. Twelve RT-SHIV infected macaques were started on tenofovir ... purposes)RetrovirologyOpen AccessResearchSequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus ... treatment [18]. Prolonged tenofovir monotherapy of macaques infected with virulentSIVmac251 resulted in the emergence of mutants with the K65R mutation in RT [19,20]. In the absence of tenofovir treatment,...
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Báo cáo y học: " Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity" ppt

... Y: Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays. ... LOH and single-copy gains and losses is the best indicator of copy number two. 2. Find the Allelic Imbalance Ratio of cn1, cn2m1 (2 with minor copy number 1) and cn2m0 (2 with minor copy number ... effects of noise), and similarly close to one in case of a very unbalanced copy number variant (such as a high copy number with loss -of- heterozygoisty) and very low normal cell content. Copy number...
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Báo cáo khoa học: " Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows" docx

... Gustafsson H, Gunnarsson A, Kindahl H. Clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis. ... activity and consequently an early increase in the progesterone levels could result in an increased susceptibility to uterine infections [20] or in a prolonged calving to conception interval ... means of the variables remaining in the logistic model for the incidence of ovarian cysts in Holstein Friesian cattle diagnosed with chronic clinical endometritis (CCE)Variable Stratum n Incidence...
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Báo cáo y học: "Psychiatric disorder as clinical presentation of primary Sjögren’s syndrome: two case reports." pdf

... characterised by a chronic inflammation of the lachrymal and salivaryglands, which leads to exocrine hypofunction and thewell recognised clinical features of dry eyes (xerophthal-mia) and dry mouth ... (xerostomia). Other exocrine glandsmay also be affected, causing a wider variety of com-plaints (for example, cough, pancreatic insufficiency, chronic sinusitis, gingivitis and laryngitis). In isolation, ... showedsinusproblemsandanepisodeofconjunctivitisinthelast 3 weeks. Focused questioning also revealed recentsubjective complaints of myalgia, dry eyes (sandy feeling) and dry mout h. The histor y of these somatic manifesta-tions...
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Báo cáo y học: "Myeloid dendritic cells display downregulation of C-type lectin receptors and aberrant lectin uptake in systemic lupus erythematosus" pdf

... and pathogens. Amongthese are the C-type lectin receptors (CTLRs). The CTLRscomprise a family of evolutionarily conserved proteins contain-ing one or more C-type lectin domains, and may bind ... differentia-tion, increased baseline maturation, augmented synthesis of proinflammatory cytokines, and increased ability to promoteincreased proliferation and activation of allogeneic control Tcells [21]. In ... washing,processing, and flow cytometry was performed as for the FDexperiments.Immunofluorescence staining and flow cytometryDCs were washed with PBS/0.2% BSA, and Fc receptorswere blocked by incubating...
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Báo cáo y học: "Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies" ppt

... aim of this study was to further examine the expression of IL-17A in actively inflamed joints and to elucidate the mecha-nism of IL-17A, alone and in combination with TNF-α and oncostatin M ... stimulates the production of cytokines and chemokines including TNF-α, IL-1, IL-6 and IL-8 [15-17].IL-17A also up-regulates MMP expression by chondrocytes and synoviocytes resulting in cartilage damage ... IL-17A induced MMP expression in human OA chondro-cytes [41] and in RA synoviocytes [18]. In animal cells IL-17Ahas been previously shown to act synergistically with TNF-α and OSM in upregulating...
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Báo cáo y học: " Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung" doc

... carcinoma is significantly influenced bytreatment mode and clinical stages of the tumor. The post-operation mortality hazard of patients treated with acombination chemotherapy and radiotherapy ... of Pathology, Tianjin Lung Cancer Center, Tianjin Medical University CancerInstitute and Hospital, Tianjin, PR China.4Tianjin Medical University, Tianjin,PR China.5Georgetown University ... attractedthe attention of many scholars. Through retrospectivelyanalyzing cases of basaloid squamous cell carcinoma of the lung and PDSC, this study examines the clinical fea-tures of basaloid s quamous...
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Báo cáo y học: "A long-term follow-up of a girl with dilated cardiomyopathy after mitral valve replacement and septal anterior ventricular exclusion" docx

... School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan, 2Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, ... up-takes of 201Tl and 123I-MIBG were detected in the anterior IVS and anteriorLV wall by cardiac scintigraphy (Figure 1). A cardiac mus-cle biopsy revealed fibrous and vacuolar degeneration in the ... 2). Both the left and right coronaryarteries were normal and there was no evidence of ischemic cardiomyopathy by an angiogram.Despite of treatment with bed-rest, diuretics and cardiot-onic...
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Báo cáo y học: "Undifferentiated giant cell type carcinoma of the gallbladder with sarcomatoid dedifferentiation: a case report and review of the literature" ppsx

... epithelial staining with only the focal staining with antiCAM5.2 suggestive of their probable histogenesis.CAM5.2 is a keratin mixture, containing a range of cytokeratins between 39 kd and 50 kd, ... gallbladder empyema in ourpatient. Incidental finding of gallbladder carcinoma follow-ing cholecystectomy for symptomatic cholelithiasis, acutecholecystitis, gallbladder empyema or even asymptomaticcholelithiasis ... abnormality was identified intra-operatively during the assessment of the peritoneal cavity,including lymphadenopathy and liver or peritoneal pathol-ogy. Based on the pre-operative as well as the intra-operativefindings,...
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Báo cáo y học: "Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver" pptx

... factor (TNF) induced sustained VCAM-1expression within 4 h in the lung, liver and kidney of mice[31], and increased the adhesion of highly metastaticmurine carcinoma cell line H-59, and human ... strains of C57BL/6 mice injected with B16F1 melanoma cells or polystyrene (P.S.) beads. iNOS was detected by immunofluorescent double-labeling using rabbit anti-mouse iNOS as the primary and Cy™3-conjugated ... inhi-bition of tumor growth in the secondary sites. With 2/3 of intramesenteric injected-B16F1 cells arresting in the liversinusoids, the rapid burst of NO induction triggeredapoptosis in 1/4 of the intravascular...
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