Báo cáo y học: "Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb" doc
Báo cáo Y học: Growth inhibition of mammalian cells by eosinophil cationic protein pptx
... rowth-inhibitory eect was also attenuated by this modi®cation. These results suggest that growth inhibition by ECP is dependent on cell type and is cytostatic. Keywords: cell cycle; colony formation; cytostatic ... pore- forming activity of ECP, which destabilizes lipid membranes [22] a nd is unrelated to its RNase activity [14,23]. This is consistent with data showing th...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... inhibition by p38 MAPK inhibitor was observed. This latter finding is in accordance with the study by Lai and co-workers showing that LPS induction of MMP9 in monocytes is mainly regu- lated by the ... but also of other inflammatory mediators produced by macrophages, and indirectly of inflammatory mediators by other cells induced by TNF-α stimulation. Here we investiga...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... luciferase activity could be trans- duced by non-modified adenovirus, this implies that the trans- duction by the chemically modified virus is αvβ3 integrin specific [15]. This specificity furthermore ... transfer of dnIκB into endothelial cells, adenovirus can be used as a vec- tor. Infection by adenovirus is initiated by the high affinity bind- ing of the carboxy-terminal...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Early Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)" pot
... Bayerische Julius-Maximilians-Universität, Würzburg, Germany and 2 Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, ... their glyco- sides [1]. About 65–75 % of the Pycnogenol extract are procyanidins that consist of catechin and epicatechin sub- units of varying chain lengths [1]. The quality of this...
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: "Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines'''' unexpected therapeutic properties" pot
... of these forms and of the total lysoPC concentration in plasma is expected to be highly regulated, including by the balanced activity of Table 1: Kinetic data for lysoPC inhibition of sPLA2 activity ... toxicity of excess lysoPCs cannot be ignored, so there is likely an upper limit of lysoPC dos- ages that will accomplish the inhibition without cytotox- icity. Dose l...
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P" pptx
... significantly affect the binding affinity of the EGS to the mRNA sequence but abolish its targeting activity to induce RNase P cleavage, possibly by disrupting the rec- ognition of EGS-UL49 mRNA ... manuscript. Acknowledgements We thank Doctor Feng Zhu for anti-UL49 antibody and Professor Fengyong Liu (University of California, Berkeley) for technical assistance. This work was sup-...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury" doc
... pathway[30]. Recently, leukotrienes pathway in this model has been dissected by genetically targeting the different enzymes responsible for the synthesis of eicosanoids. Indeed, lung fibrosis and inflammation ... investigated the efficacy of pharmacological inhibition of leukotrienes activity in the development of bleomycin-induced lung injury by comparing the responses in wil...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: " Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome" pps
... mutant R1 may lack target sequences for trans -inhibition by AS19. Mechanism of trans -inhibition by HIV-lhNef and the AS variants We have previously described strong inhibition of HIV-1 by RNAi-inducing ... http://www.retrovirology.com/content/4/1/15 Page 11 of 14 (page number not for citation purposes) Test of sequence-specificity of the inhibition by HIV-lhNefFigur...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: " Correction: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120" doc
... 1 of 3 (page number not for citation purposes) Retrovirology Open Access Correction Correction: Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged ... Binley et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/li...
Ngày tải lên: 13/08/2014, 09:20