Báo cáo y học: " Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome" pps

... or long hairpin RNAs (lhRNAs). The use of siRNA and shRNA as antiviral therapeutic is limited because of the emergence of viral escape mutants. This problem is theoretically prevented by intracellular ... mutant R1 may lack target sequences for trans-inhibition by AS19. Mechanism of trans-inhibition by HIV-lhNef and the AS variants We have previously described s...

Ngày tải lên: 13/08/2014, 09:20

... in the pathogenesis of rheumatoid arthritis Xiaotian Chang 1 , Ryo Yamada 1 and Kazuhiko Yamamoto 1,2 1 Laboratory for Rheumatic Diseases, SNP Research Center, The Institute of Physical and ... Chemical Research (RIKEN), Kanagawa, Japan 2 Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan Corresponding author: Xiaotian Chang,...

Ngày tải lên: 09/08/2014, 06:22

... writing of the oral terms used by Maya peasants can lead to confusions. For example, the com- posite expression of Yaax kom lu’ um means literally the soil around a poo rly drained area”, while Yaax ... general large areas. Only Ak’al che’ soils occur as small patches in swampy lowlands [28]. Yucatec Maya farmers use also the type and density of individual plants and plant c...

Ngày tải lên: 10/08/2014, 09:20

... muscle layers. The vasa recta, which supply the mucosa and submucosa of the colon, penetrate the circular muscle. The weakness of the vascular portals in the circular muscle possibly causes ... recovery was une- ventful, and the patient was discharged on postoper- ative day 4. Fig.1 Fluid collection and left ovary cyst was noted on computed tomography. The size...

Ngày tải lên: 25/10/2012, 10:51

... consumption Table 1 summarizes the results of our laccase oxidations of substrates 1–5, and the effect of the cosolvent and of the mediators on the amount of substrate metabolized by the enzyme. (a) Laccase ... rate. Quantitation of unreacted substrate was achieved by using 2-bromonaphtalene (Aldrich) as the internal standard. The standard was added to the r...

Ngày tải lên: 21/02/2014, 01:21

... other symptoms. Past medical history was unremarkable. Family history was significant for lifelong history of polycythemia in her mother, maternal grandmother and her younger sister. Physical ... Tefferi A, Thiele J, Orazi A, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and prim...

Ngày tải lên: 08/08/2014, 16:23

... models of arthritis [45,46]. Monocytes and macrophages synthesize and release into their environment a variety of cytokines and other proteins that play a central role in the development of acute and ... observation that may explain why inflammatory diseases of some organs but not of other organs respond to methotrexate therapy. Introduction Low-dose weekly methotrexate has be...

Ngày tải lên: 09/08/2014, 07:20

... Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S, Maruyama I: High mobility group box chromosomal protein 1 plays ... O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ:...

Ngày tải lên: 09/08/2014, 10:23

... unclear whether this strategy will have an impact as a therapy on a virus as heterogeneous and rap- idly changing as HIV. What was quite clear was the value of this approach as a basic research tool ... recently released data on promising phase I studies on the matura- tion inhibitor PA-457, the first of its class to enter clinical trials. The chapter on RNAi is a nice sum...

Ngày tải lên: 10/08/2014, 05:20

... Ducic Y: Nasal gliomas. J Otolaryngol 1999, 28:285-287. 8. Uemura T, Yoshikawa A, Onizuka T, Hayashi T: Heterotopic nasopharyngeal brain tissue associated with cleft palate. Cleft Palate Craniofac ... feed on initial evalua- tion. A physical examinati on revealed no gross craniofa- cial abnormalities; our patient was a healthy baby with a large (6 cm × 8 cm) palpable mass in the lef...

Ngày tải lên: 10/08/2014, 23:21