Báo cáo y học: " The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies" ppsx

... Okazaki T, Koji T, Miyanishi T, Yamada Y, Kamihira S: A novel alternative splicing isoform of human T-cell leukemia virus type 1 bZIP factor (HBZ-SI) targets distinct subnuclear localization. J Virol ... and by targeting JunB to HBZ-NBs. This hypothesis is confirmed by the data obtained with JunD. Indeed, HBZ stimulates JunD transcriptional activity [32], does not mod...

Ngày tải lên: 13/08/2014, 09:20

... affect the rate in many d ifferent ways. Recent kinetic and thermodynamic studies of the stability of mammalian oxymyoglobins have shown that the autoxidation reaction is not a simple, dissociative ... speci®cally, the b chain h as acquired this stability by blocking out the proton catalysis performed by the distal histidine residue (Eqn 4). Similarly, Shaanan [31] reporte...

Ngày tải lên: 31/03/2014, 15:20

... Ehrlichiosis: making the diagnosis in the acute setting. South Med J 2007, 100:825-828. 7. Li JS, Chu F, Reilly A, Winslow GM: Antibodies highly effective in SCID mice during infection by the intracellular ... laboratory confirmation criteria for ehrlichiosis, and response to doxycycline provides supporting clinical evidence. The Panola Mountain Ehrlichia species, an emerging pathog...

Ngày tải lên: 11/08/2014, 23:21

... significant, inhibitory effect on the p53- inhibitory activity of Meq (data not shown). In contrast, the inhibitory effect of Meq on the transcriptional activ- ity of p53 was attenuated significantly ... abrogation of p53 transcriptional activity in virus- induced oncogenesis are not understood fully, the main mechanism employed by oncoviruses involves the direct bind...

Ngày tải lên: 12/08/2014, 02:20

... and 12 days post-infection were determined by RT assays. While wild -type virus rep- licated in Hos cells, as indicated by the increasing amounts of RT activity in the culture medium over time, no ... domain of Gag plays a critical role dur- ing virus replication. Initial experiments showed that deletion of this motif did not inhibit the release of virions as demonstr...

Ngày tải lên: 13/08/2014, 09:21

... stability of the mature HIV-1 capsid. The very high chemical activity of CA in the maturing virion may promote association through the CA–CA interfaces identified, even though both retroviral ... occur at this interface, at least in RSV [40]. Second, the inhibitory activity of isolated CTD on the in vitro polymerization of CA from HIV-1 was found to be relieved by add...

Ngày tải lên: 18/02/2014, 06:20

... original wild -type CAI (approximately 15 lm; see above) and with the CTD domain itself can be explained by the higher helicity of the isolated peptide (i. e. the NYAD-1 peptide, unlike CAC1, CAI ... because of the omnipresent nature of pro- tein–protein interactions in key steps during the virus life cycle, it is possible to design antiviral strategies based on the...

Ngày tải lên: 18/02/2014, 06:20

... gammaretroviruses) [8]. Other lentiviruses such as feline immunodeficiency virus, equine infectious ane- mia virus, simian immunodeficiency virus and HIV-2 use tRNA Lys3 as a primer. Human lysyl-tRNA synthe- tase ... transcription of viral RNA [33–35]. Furthermore, CsA prevents the incorporation of CyPA into virions, resulting in reduced infectivity. The necessity of CyPA for...

Ngày tải lên: 07/03/2014, 00:20

... in the case of chart review, missing information often limits the ability of reviewers to identify adverse events or judge their preventability. Thus, an efficient method for identifying adverse ... such physicians in medical emergency teams will likely facilitate the dual roles of these as a clinical outreach arm of the intensive care unit and in identifying problems in care...

Ngày tải lên: 25/10/2012, 10:06

... Department of Plastic Reconstructive and Aesthetic Surgery, Dokuz Eylul University, Faculty of Medicine, Izmir, TURKEY. 2. Clinic of Plastic Reconstructive and Aesthetic Surgery, Public Hospital, ... superior to the origin of the temporal muscle. Then, the TPF is ele- vated from the deep temporal fascia by blunt dissec- tion. If lengthening of the pedicle is needed, p...

Ngày tải lên: 25/10/2012, 11:00