Báo cáo y học: " Retroviral activation of the mir-106a microRNA cistron in T lymphoma" potx

... transcript is located to the left of the retroviral tag on the chromosome, the notation for the gene precedes the notation for the tag (G ± T ). If the transcript is to the right of the retroviral ... also of the mature species of the mir- 106a cluster. This, in turn, suggests that the miRNA cluster can drive the development of T lymphomas. Al...

Ngày tải lên: 13/08/2014, 09:20

... activity detected in the anti-HA immunoprecipitate in an individual experi- ment. At the bottom is the quantification of the level of the activation of JNK ac tivity induced by CD53 ligation in ... epitope antibody. JNK activity was measured in the immunoprecipitate by the incorporation of radioactivity in the GST–ATF2 fusion protein used as substrate. At t...

Ngày tải lên: 08/03/2014, 22:20

... involved in integrin αvβ3-mediated bone resorption [19,34-36]. Interestingly little is known about the activation of these proteins in RA ST. In this study we demonstrated the phosophorylation of FAK ... nonreceptor protein tyrosine kinases that are acti- vated by a variety of extracellular stimuli [1]. FAK and Pyk2 associate with the cytoskeleton and with integrin-signali...

Ngày tải lên: 09/08/2014, 10:21

... disease, starting, in the initial phase, at the syn- ovial lining layer, gradually shifting toward the subintimal region and eventually, in the destructive phase, persisting in pannus tissue. Moreover, ... visible, mostly in the lining layer of the synovium (Figure 1b). With increasing severity, characterized by infiltration of inflammatory cells and synovial hyperplas...

Ngày tải lên: 09/08/2014, 13:22

... space or other affected organs in order to maintain a steady-state concentration at the site of inflammation. pGSN has the poten- tial to interact with several macromolecules present at sites of inflammatory ... were detected in SFs of 77 of the 81 RA patients and in plasmas of 19 of the 78 patients by immu- noblotting (Figure 4a). In addition, very low concentrati...

Ngày tải lên: 09/08/2014, 13:22

... questions relating to the management of the acute phases of their injuries. Specifically, the mode of treatment was docu- mented vis-à-vis the attempt at inducing emesis before presenting at the ... 5 (page number not for citation purposes) ingestion of acids. Attempt at spiting out the acid may lead to tell-tale signs on the skin of the chest. Alkalis tend to affect...

Ngày tải lên: 10/08/2014, 10:20

... (95% N 2 ,5%CO 2 )wasinfusedintotherightatriumanda constant pressure within the left atrium of 2 cm H 2 O was maintained during the whole procedure. In order to monitor the gas-exchange capacity of the lung, the oxy- gen ... administered, the increased liberatio n of Lb in our study might at least in part be a consequence of the mechanical ventilation. The dysfun...

Ngày tải lên: 12/08/2014, 13:22

... catheter in situ. The picture shows the microdialysis catheter in the distal bronchus. The distal white part is the microdialysis membrane. It is this part of the catheter that is in contact ... Microdialysis AB, Stockholm, Sweden), using the peroxidase methodology. To verify the position of the catheter at the end of the experiment, the microdialysis cat...

Ngày tải lên: 12/08/2014, 15:21

... a vector corresponding to the right-hand-side terms in [6] after absorption of the fixed effects and the effects of the ancestors of the other sex. Expectation of the quadratic ... parameters MAP estimates of 0 maximize the logarithm of the posterior density L(0 ) written in !6!. Setting the first derivatives to 0 leads to a n...

Ngày tải lên: 09/08/2014, 18:22

... indiscriminately throughout the world. They frequently result in devas- tating effects mainly among civilians in post conflict situations. In addition to causing death, injury and dis- ability, landmines ... contributions The three authors participated in designing the study. SNP and THI carried out the data collection. AH TS and SNP carried out the data analysis. SNP and TH...

Ngày tải lên: 13/08/2014, 14:20