Báo cáo y học: " Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3" docx
Báo cáo y học: " Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3" docx
... samples, and HH grew the crystals and performed crystallographic analysis. BET and JHE developed the TL-3 inhibitor, and JHE directed the design of the 12X chimeric FIV protease. CDS super- vised the ... Liu F, Kovalevsky AY, Louis JM, Boross PI, Wang Y- F, Harrison RW, Weber IT: "Mechanism of Drug Resistance Revealed by the Crystal Structure of the Unligand...
Ngày tải lên: 13/08/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt
... [21], and the more recently published novel two-domain laccases [22–24]. The other phylum of the fungi, the Ascomycota or sac fungi, is much less studied, and only the crystal structure of Melanocarpus ... nitrogens of His residues. On the basis of the elec- tron density, we refined one oxygen atom (probably a hydroxide) between the type 3 coppers in molecules B, C...
Ngày tải lên: 14/02/2014, 18:20
Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
... pairs of hydrogen bonds are formed in the active site of hTRXL-N (Fig. 4), accounting for the compactness and stability of the active site. The H-bond length between the carbonyl oxygen of Cys34 and ... interaction with the N-terminal domain, the mechanism of regulating the catalytic activity may be similar to that of the dimer. In other word, the active site...
Ngày tải lên: 08/03/2014, 22:20
Báo cáo y học: "Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep" pdf
... acids and 100 µg/ml kan- amycin as previously described [8]. Southern blot, PCR, RT-PCR and sequence analysis Genomic DNA was prepared and analyzed by Southern blot and PCR analysis as previously ... is linked with the onset of acute leukemia. We propose that in this particular case, the mechanism by which the immune system destroys developing malignancies is evaded by the maligna...
Ngày tải lên: 13/08/2014, 05:22
Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx
... toxicity and lack of efficacy, most of the compounds currently used for chemotherapy are unsatis- factory and the design of novel classes of antitrypanoso- matid drugs has become urgent. Glycolysis ... poorly resolved. The stereochemistry of the structure is generally quite satisfactory, with more than 99% of the residues showing torsion angles in the favourable reg...
Ngày tải lên: 20/02/2014, 02:21
Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... pathways for the synthesis of IAA in these organisms have been described, and most of them start from L -tryptophan as precursor. One of the tryptophan- dependent biosynthetic routes to IAA is the ... diphosphate-dependent enzyme indolepyruvate decarboxylase catalyses the formation of indoleacetaldehyde from indolepyruvate, one step in the indolepyruvate path- way of biosy...
Ngày tải lên: 20/02/2014, 11:20
Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... APP can be hydrolyzed by the b secretase activity at the N-terminus of Ab, which is successively released by the c secretase after cleavage within the membrane [6] either between residues 40 and ... that the second helix (residues 28–38) corresponds to the transmembrane region of APP, and has the typical amino acid composition of transmembrane helices, i.e. small (Gly and...
Ngày tải lên: 08/03/2014, 09:20
Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... protein crystallography. Acta Crystallogr D: Biol Crystallogr 50, 760–763. 37 Evans P (2006) Scaling and assessment of data quality. Acta Crystallogr D: Biol Crystallogr 62, 72–82. 38 McCoy AJ, ... only accommodated in the P4 site, but makes significant interactions with importin-a. This primarily occurs by the formation of a hydrogen bond between the side-chain hydroxyl group of...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... ApeSODs. Crystallization and determination of structure The crystals of ApeSOD were grown for 2–3 days in the presence of polyethylene glycol. The crystals belonged to the space group P2 1 , with ... NE2 of His79 and NE2 of His169, formed an equatorial plane. The other protein ligand, NE2 of His31, bound to the metal, in the company of a water oxygen, from t...
Ngày tải lên: 14/02/2014, 22:20
Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... similarity, the sequence identity with PhyK is only 22.6 and 23.2%, respectively. The overall fold of PhyK is evolutionarily highly conserved. The human enzyme PAP can be superim- posed with an rmsd ... Thus, the differences between wild-type and mutant structure are in the same range as the dif- ferences between the two molecules of the asymmetric unit of the...
Ngày tải lên: 16/02/2014, 09:20