Báo cáo y học: " Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3" docx
Báo cáo y học: " Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3" docx
... samples, and HH grew the crystals and performed crystallographic analysis. BETand JHE developed the TL-3 inhibitor, and JHE directed the design of the 12X chimeric FIV protease. CDS super-vised the ... Liu F, Kovalevsky AY, Louis JM, Boross PI, Wang Y- F, Harrison RW,Weber IT: "Mechanism of Drug Resistance Revealed by the Crystal Structure of the Unliganded HIV-1 Protease with F53L Mutation". ... purposes)Comparison of the flap regions of wild-type FIV protease, 12X FIV protease, and wild-type HIV proteaseFigure 5Comparison of the flap regions of wild-type FIV protease, 12X FIV protease, and wild-type...
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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt
... [21], and the more recently published noveltwo-domain laccases [22–24]. The other phylum of the fungi, the Ascomycota or sac fungi, is much less studied,and only the crystal structure of Melanocarpus ... nitrogens of His residues. On the basis of the elec-tron density, we refined one oxygen atom (probably ahydroxide) between the type 3 coppers in molecules B,C and D in the asymmetric unit of the crystal ... (asco-lac-cases) have been rather unexplored, and to date only the crystal structure of Melanocarpus albomyces laccase (MaL) has been published. We havenow solved the crystal structure of another asco-laccase,...
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
... pairs of hydrogen bonds are formed in the active site of hTRXL-N (Fig. 4), accounting for the compactness and stability of the active site. The H-bondlength between the carbonyl oxygen of Cys34 and ... interaction with the N-terminal domain, the mechanism of regulating the catalytic activity may be similar to that of the dimer. Inother word, the active site would be physically blocked andwould ... stabilized by an S–O hydrogen bond with the hydroxyl of Thr76 (bond length 3.3 A˚), which is not presentin 1ERU and 1ERT due to a substitution of Thr76 forMet74. The carbonyl oxygen of Gly35 forms...
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Báo cáo y học: "Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep" pdf
... acids and 100 µg/ml kan-amycin as previously described [8].Southern blot, PCR, RT-PCR and sequence analysisGenomic DNA was prepared and analyzed by Southernblot and PCR analysis as previously ... islinked with the onset of acute leukemia. We propose thatin this particular case, the mechanism by which the immune system destroys developing malignancies isevaded by the malignant cell by reducing ... evidence for the role of virus and oncogene silenc-ing as an important step in the onset of lymphoid malig-nancy. In the first animal, S2531, we identified acorrelation between the genetic...
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Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx
... toxicity and lack of efficacy, most of the compounds currently used for chemotherapy are unsatis-factory and the design of novel classes of antitrypanoso-matid drugs has become urgent. Glycolysis ... poorly resolved. The stereochemistry of the structure is generally quite satisfactory, with morethan 99% of the residues showing torsion angles in the favourable regions of the Ramachandran diagram ... binding sites of an analogue of the thioacyl intermediate for the Trypanosoma cruziglyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction,from its crystal structure. Biochemistry 42, 7143–7151.30....
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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc
... pathways for the synthesis of IAA in theseorganisms have been described, and most of them startfromL-tryptophan as precursor. One of the tryptophan-dependent biosynthetic routes to IAA is the ... diphosphate-dependent enzyme indolepyruvatedecarboxylase catalyses the formation of indoleacetaldehydefrom indolepyruvate, one step in the indolepyruvate path-way of biosynthesis of the plant hormone indole-3-aceticacid. ... extends from the thiazoliumring of the cofactor to the surface of the protein. The entrance of the active site cleft is covered by the C-terminalhelix and this part of the polypeptide chain...
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... APP can be hydrolyzed by the b secretaseactivity at the N-terminus of Ab, which is successivelyreleased by the c secretase after cleavage within the membrane [6] either between residues 40 and ... that the second helix (residues 28–38) corresponds to the transmembrane region of APP, and has the typicalamino acid composition of transmembrane helices, i.e. small(Gly and Ala) and hydrophobic ... into the membrane [38].Accordingly, it is possible that the mechanism of membraneinteraction and destabilization is different in the case of Ab,but it is fair to say that the similarity with the...
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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... protein crystallography.Acta Crystallogr D: Biol Crystallogr 50, 760–763.37 Evans P (2006) Scaling and assessment of data quality.Acta Crystallogr D: Biol Crystallogr 62, 72–82.38 McCoy AJ, ... only accommodated in the P4 site,but makes significant interactions with importin-a.This primarily occurs by the formation of a hydrogenbond between the side-chain hydroxyl group of Tyr205and ... loop. The hydrogen bond formed betweenTyr205 and the carbonyl oxygen of impaArg106()2.8res) decreases significantly the BÀapozscore for the residue. This is also seen for the other Tyr205-sharedhydrogen-bonding...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... ApeSODs.Crystallization and determination of structure The crystals of ApeSOD were grown for 2–3 days in the presence of polyethylene glycol. The crystalsbelonged to the space group P21, with ... NE2 of His79 and NE2 of His169,formed an equatorial plane. The other protein ligand,NE2 of His31, bound to the metal, in the company of a water oxygen, from the apical positions. The manga-nese ... ApeSOD, the metal was coordi-nated with six ligands: the five same ligands in the Mn-reconstituted enzyme and an additional water oxy-gen, which, together with the OD2 of Asp165, the NE2 of His79 and...
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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... similarity, the sequence identity with PhyK is only 22.6 and 23.2%, respectively. The overall fold of PhyK is evolutionarily highlyconserved. The human enzyme PAP can be superim-posed with an rmsd ... Thus, the differences between wild-typeand mutant structure are in the same range as the dif-ferences between the two molecules of the asymmetricunit of the wild-type structure. Neither the ... occupancy of 0.6–0.8 to account for the likelyeffect of radiation damage [33].In order to determine the structure of the complex of an inactive PhyK mutant with its substrate phytase, the refinedstructure...
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