... a therapeutic target in AKI. Modulation of these cytokines may reduce the degree of kidney injury itself,as well as the deleterious effects of kidney injury on other endorgans, including the ... is the surgery and bypass itself. Thus, the tim-ing of the insult is clear. Based on our animal studies, wehypothesized that levels of proinflammatory cytokines wouldincrease early after the ... University of Cincinnati School of Medicine, Cincinnati, OH, USA4Section of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine,...