Báo cáo y học: " PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA" pps

... arginine methylation of the N-termi- nal portion of the ARM of Rev by PRMT6. This methyl- transferase reduced RRE binding and diminished export of viral RNA to the cytoplasm in cell-based assays. Co- immunoprecipitation ... methyltransferase activity, but seems to be caused by a yet undefined activity of PRMT6, which may be linked to the proteasome pathway, as prev...

Ngày tải lên: 13/08/2014, 09:20

... 21400, Diyarbakir, Turkey, 2 Department of Radiology, Diyarbakir Education and Research Hospital, Op Dr Seref Inaloz Caddesi, 21400, Diyarbakir, Turkey and 3 Department of Pathology, Diyarbakir ... rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol 2006, 6:26. 4. Demos TC, Malone AJ Jr: Computed tomography of a giant renal oncocytoma. J Comp...

Ngày tải lên: 11/08/2014, 11:22

... of neoplastic lymphocytes may result in a loss of coherence between basal keratinocytes and basal lamina [7] or the cohesion of keratinocytes m ay be affected by the release of lymphokines by ... lymphadenopathy nor organomegaly were present. Histological examination of these lesions revealed subcorneal and intra-epidermal bullae accompanied by infiltra tes of atypica l lympho...

Ngày tải lên: 11/08/2014, 11:23

... transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology 1995, 213:439-449. 5. Meyer BE, Malim MH: The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. ... (the 4 Kb singly spliced and 2 Kb fully spliced RNAs) [1]. While the fully spliced RNAs are exported to the cytoplasm, where they are translated into the regulatory...

Ngày tải lên: 10/08/2014, 05:20

... high affinity (step 4). Binding of K + leads to dephosphorylation of the enzyme andtotheocclusionoftwoK + cations (step 5). K + is then released to the cytosol after ATP binds to the enzyme with ... K + ions to flow out of the cytosol. This is probably the reason for the high toxicity of palytoxin, as the outflow of K + and the resulting collapse of the membrane potential...

Ngày tải lên: 24/03/2014, 00:21

... Hesselbrock V, Meyer RE, Dolin- sky ZS, Rounsaville B: Types of alcoholics. I: evidence for an empirically derived typology based on indicators of vulnera- bility and severity. Arch Gen Psychiatry 1992, ... 1 of 4 (page number not for citation purposes) Annals of General Psychiatry Open Access Review A short review on the aetiology and pathophysiology of alcoholism George Moussa...

Ngày tải lên: 08/08/2014, 23:21

... VEGF, and bone specific alka- Editorial What do biomarkers tell us about the pathogenesis of ankylosing spondylitis? Walter P Maksymowych Department of Medicine, University of Alberta, Edmonton, ... growth factor (VEGF) but not with serum MMP3 [5,6]. Third, biomarkers may clarify our understanding of the pathophysiology of disease. Unlike rheumatoid arthritis, there is still no fo...

Ngày tải lên: 09/08/2014, 01:22

... redundancy of the system, based on in vitro studies. Because one receptor can usually bind multiple ligands and vice versa, one may anticipate that blockade of one ligand or receptor may be compensated ... found in many inflammatory disorders, including hepatic disease, multiple sclerosis, transplant rejection and inflammatory bowel disease [4]. Analysis of synovial tissue, synovial...

Ngày tải lên: 09/08/2014, 01:23

... necrosis factor receptor type II (exon 6) and interleukin-6 (-174) gene polymorphisms are not associated with family history but tumor necrosis factor receptor type II is associated with hypertension ... association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypes. Rheu- matology (Oxford) 200...

Ngày tải lên: 09/08/2014, 06:23

... capillaries of the synovium and must diffuse into the synovial fluid and then into the cartilage matrix. Co- ordinated synthesis and proteolytic breakdown of certain ECM components by chondrocytes enables ... Elders EM, Gay S, Tomaino MM, et al.: Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human...

Ngày tải lên: 09/08/2014, 10:20