Báo cáo y học: "Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination" pot

... recombination in the conserved regions of the env genes of multiple HIV-1 subtypes. However, only the appropriate sequence combination can generate similar hairpins in a hypervariable region of the donor ... 1 of 17 (page number not for citation purposes) Retrovirology Open Access Research Influence of sequence identity and unique breakpoints on the freque...

Ngày tải lên: 13/08/2014, 09:20

... acting site and drug binding pocket along with other HRV-C members. Our study compared nonsynonymous and synon- ymous substitution at the protein level of the HRV- CU072 strain with its phylogenetically ... and nonsynonymous (NS) variation at the protein level w as investigated (Table 2). In this analysis, nonsynonymous changes w ere defined as 2 types of variation: nonconserv...

Ngày tải lên: 11/08/2014, 21:21

... affect the H. pylori infection through the level of cytokines which are advantageous to eradication of H. pylori. These results should be interpreted with caution. The question is whether these ... epidemiological and biologically plausible observation would stimulate interest in the study of the molecular mechanisms of action of this polymorphism. Because these res...

Ngày tải lên: 31/10/2012, 15:37

... role of the D to N mutation; and (c) the role of the sequence and length of the C-terminal extension. To address whether presence of extra residues at the N-terminal of Pfg27 A were responsible ... partially soluble in five of the constructs resulting in very poor yields. Intriguingly, in the sixth con- struct, the yield of soluble fusion protein with an ext...

Ngày tải lên: 23/03/2014, 21:20

... that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri Jason Doyle 1 , Lyndon E. Llewellyn 1 , Craig S. ... University of Adelaide, South Australia Two neuropeptides have been isolated and identi®ed from the secretions of the skin glands of the Stony Creek Frog Litoria l esueuri...

Ngày tải lên: 31/03/2014, 15:20

... For the 20-week and 22-week CHB hearts, there was a strong positive cor- relation between the absolute number of macrophages and the content of myofibroblasts. The functional implication of the ... clearance and cytokine secretion may vary, these scavengers phagocytose both nonopsonized and opsonized apoptotic cells. Concomi- tantly or alternatively, macrophages may pr...

Ngày tải lên: 09/08/2014, 01:22

... Hoogen FH: The synergistic value of focus score and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjogren’s syndrome: a 10- year comparison. Rheumatology 2002, ... sera and that the majority of these antibodies are of the IgG and IgA class, but that their frequency in SjS sera is not higher than that of the classic autoant...

Ngày tải lên: 09/08/2014, 01:23

... better definition of the cellularity requirement of functional cartilage development; and evaluation of potential harmful effects of local acidosis caused by degradation of the biomaterial. Another potential ... application may be impossible in certain areas of the joint because of anatomic factors, and the fixation of the periosteal flap or collagen sheets cover...

Ngày tải lên: 09/08/2014, 10:21

... autonomous of inflammation [5]. At the dawn of the era of biological therapy in RA, this theory led to the concept of a dual-therapeutic strategy, including anti-inflammatory biological therapy, ... is secondary and a predictable consequence of synovitis, with the added caveat that sites of joint compression may be more prone to erosion (Figure 3). However, we feel that...

Ngày tải lên: 09/08/2014, 13:22

... occa- sional inflammation of the synovium, osteophytosis and alterations in the subchondral bone. It is often hypothesized that subchondral bone changes play an important role in either initiation ... interests. Authors' contributions MC participated in the design of the study, analysis of DXA images, performed the statistical analysis and drafts the man- uscript. J...

Ngày tải lên: 09/08/2014, 14:22