Báo cáo y học: " Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants Patrick Kaumanns, Isabel Hagmann and Matthias T " pps

... purposes) Retrovirology Open Access Short report Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants Patrick Kaumanns, Isabel Hagmann and Matthias T Dittmar* Address: ... study it is tempting to speculate that they might not only be restricted by TRIM5α but also by Lv2 or yet another unk...

Ngày tải lên: 13/08/2014, 09:20

... actively exported to the cytosol and thereby permitting a sustained NF-κB-dependent activity by free p65wt. The active shut- tling of ΔNH 2 p65 from the nucleus to the cytosol would explain why it largely ... transactivation and ultimately leads to apoptosis. Therefore, caspase-3-related proteolysis may determine the duration of NF-κB activity in stimulated T cells and may play a...

Ngày tải lên: 13/08/2014, 05:21

... indicate that the inhibitory effect of RA sera is evident only in patients with active disease. To explore the disease specificity of this inhibitory activity further, sera from patients with ankylosing Figure ... levels. The present results confirm that patients with RA do not have an increased serum concentration of ApoA-1 compared with that of healthy controls. Consequently, the st...

Ngày tải lên: 09/08/2014, 07:20

... we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats. Methods Rat apoptotic thymocytes were injected intraperitoneally (2 ... efficient to induce and sustain SCW inflammation. Indeed, apoptotic cell injection acts in two different ways. First, apoptotic cells together with phagocytes that digest apoptotic cells...

Ngày tải lên: 09/08/2014, 14:22

... adaptive immunity, DCs constitute the most pow- erful antigen presenting cells (APCs) that prime naïve T lymphocytes and sensitize cytotoxic T lymphocytes to the antigens they present [13]. Thus, ... addi- tion, they are tractable for stable genetic modification. These attributes qualify them as potential candidates to derive an unlimited supply of any cell type for transplan- tation,...

Ngày tải lên: 10/08/2014, 05:20

... interpreted as limitation of the present study. Our future perspectives are to widen the research on other drugs with potential anti-apopto- tic effect. Another limitation is that i n this study ... evaluation and participated in the study design and coordination. EU performed the statistical analysis. MR and MM participated in the experiments and data evaluation. HA and GZ concei...

Ngày tải lên: 10/08/2014, 10:20

... progenitors, the withdrawal of cytotro- phoblasts from the cell cycle to G 0 , the recruitment of these post-mitotic cells to syncytiotrophoblast after mem- brane fusion and progression of syncytiotrophoblast towards ... showed the con- tinuity of syncytin 2 immunostaining between the cytoplasm surrounding the nuclei and that of the thin elongated cytoplasmic processes. Syncytin...

Ngày tải lên: 13/08/2014, 06:20

... 2 Department of Pathology, Ippokration Hospital of Salonica, Greece, 3 Department of Histology – Embryology, Democritus University of Thrace, Greece and 4 Department of Obstetrics and Gynecology, ... does not necessarily relate Hodgkin and R-S cells to activated lymphocytes. The identification of this antigen in cells as apparently dis- parate as activated lymphocytes, R...

Ngày tải lên: 13/08/2014, 22:22

... assay, rPFL displayed highest activity at 29 °C and pH 8.0, in good agreement with results reported for the wild type enzyme [30]. Interestingly, the enzyme lost most of its activity at 50 °C but ... hypothesis that PFL might be secreted by a signal peptide-independent pathway and calls for further investigation on this subject. Enzyme activity and specificity In the standard tricapryl...

Ngày tải lên: 24/03/2014, 04:21

... Management of extremity soft tissue sarcomas with limb-sparing surgery and postoper- ative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local ... summary of what is currently known is the topic of the present review. Pain as a presenting symptom of peripheral nerve tumors Of clear importance is the ability to differentiate...

Ngày tải lên: 10/08/2014, 10:20