Báo cáo y học: " HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-γc-/- (RAG-hu) mouse model" docx

... post- infection. To further investigate CD4 T cell depletion at the infected tissue level, thymus from an uninfected control and infected mouse (same tissues as detailed above for HIV in situ hybridization) ... only the X4 virus infection resulted in CD4 Detection of HIV-1 in infected RAG-hu mouse tissues by in situ hybridizationFigure 5 Detection of HIV-1...

Ngày tải lên: 13/08/2014, 09:20

... suggesting that Tregs indeed contri- bute to effector T cell dysfunction and inability to clear the infection. Acute HIV-1 infection is usually charact erized by mild flu-like symptoms and henc ... infected lymphatic tissues, suggesting that Tregs either redistribute to infected tissues, proliferate there, or both [36,55]. Tregs at the sites of infection are associated wit...

Ngày tải lên: 13/08/2014, 01:21

... observed in this study, one interpretation of our finding is that the majority of the glutamatergic terminals that target pyramidal neurons in layer 3 of the PFC are functionally disturbed in schizo- phrenia ... immunohistochemistry in combi- nation with quantification of axonal boutons afforded us a higher sensitivity in detecting differences in the present study. In t...

Ngày tải lên: 11/08/2014, 17:20

... elements. It is interesting to note that the integrase proteins encoded by LTR-RTs differ between the Pseudoviridae and the Metaviri- dae in their carboxy-terminal domains, as they have different characteristic ... euchromatin and preferential targeting of heterochromatin. Constant turnover of euchromatic insertions and a decline in activity for the elements that target hete...

Ngày tải lên: 14/08/2014, 14:21

... of the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript. Competing interests The authors declare that they ... Secondary infectio n with SS7 improved the dis- tribution of the strain HuN4. The strain HuN4 was detected in all the 9 examined organs in the 8 deceased pigs; the...

Ngày tải lên: 12/08/2014, 04:20

... not investi- gated further. In contrast to the above mixed infection cases with iso- lates showing different DST patterns, it is remarkable to note that the remaining 11 patients were infected ... both a susceptible and a resistant strain in the corresponding specimens. This systematic duality was evidenced by the systematic detection of dou- ble alleles in the MIRU-VNTR p...

Ngày tải lên: 12/08/2014, 16:20

... patients and HC controls, with an expan- sion in the former and a reduction in the latter. Overall, these results suggest that the integration of the TGBb and RA pathways that are involved in the ... defective, either because there are too many memo ry T cells or they are refractory to RA inhibition. Interestingly, the CD25 - Tregs were also expanded by the combina...

Ngày tải lên: 12/08/2014, 17:22

... conservative. This rapid elimination of the secondary strain is not expected from the initial state of the multiple -infection. As shown in the Results section, the secondary infecting strain initially ... our study is to examine the amount, patterns and evolution- ary significance of inter- and intragenic recombination both within single infection strains and between s...

Ngày tải lên: 12/08/2014, 23:21

... assigned time for eye examination. Parents who had expressed hesi- tancy or reluctance to participate in this study were invited to a seminar for further information on the study. The study only included ... and the data from left eyes had fewer outliers, only the data from left eyes were presented in this report. The distribu- tions of refractive status were further anal...

Ngày tải lên: 25/10/2012, 11:40

... available to make this determination. In an attempt to test the simple hypothesis that class II XI stability at high temperatures correlates with its N þ Q content, independent of the growth temperature ... differences in stabilization efficacy between metals may be due to their ability to adopt different geometries in the same site in the absence of substrate. In the cryst...

Ngày tải lên: 22/02/2014, 07:20