Báo cáo y học: " Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1" docx

... homeostasis, maintenance of tolerance, and prevention of the onset of autoimmune disease. Their existence is no longer in question, but true to their history these cells, their origin, generation, ... CD4 + CD25 – T cells, together with TCR antigen stimulation, into the regulatory phenotype. Elemental to this conversion process is induction of expression of the f...

Ngày tải lên: 09/08/2014, 06:22

... IL-10- producing T regulatory 1 cells. Altogether, HSP60 may induce Tregs in the joints of JIA patients and thereby regulate the inflammation of these JIA patients, as is seen in oligoarticular JIA. ... while polyarticular patients did not [65]. This finding suggests a correlation between disease severity and HSP60 reactivity of T cells in these patients, in...

Ngày tải lên: 09/08/2014, 14:20

... collapse due to the transloca- tion of B -in to the lumen of the lymphatic vessels of the nodes. We predict that these translocated B -in cells obstruct the lymphatics of the lower limb resulting in decreased ... signal intensity at the injec- tion site immediately after administration and 24 hours later. To quantify lymphatic draining in ILN, 6 μlof ICG...

Ngày tải lên: 12/08/2014, 17:22

... another. The accumulated contributions of synonymous codons of an amino acid to the total folding energy of an mRNA is strongly correlated to the relative amount of that amino acid in the translated ... to form structures. However, the FE has only a small free component, less than 10% of the total. The contribution of the 1st and 3rd codon bases to the...

Ngày tải lên: 13/08/2014, 16:21

... control T cells are equally susceptible to HIV-1 in the absence of DC, demonstrating that the DC-mediated transmission itself is impaired, instead of the ability of HIV-1 to infect these cells. The ... smaller number of T cells that is tightly attached to DC will result in a decrease of the window of opportunity for HIV-1 transmission. Fu...

Ngày tải lên: 13/08/2014, 09:20

... respectively. In addition, the 714insT or G is closely flanked by an interferon response factor-1 binding motif at the upstream regulatory element of HLA-G gene. Taken together, the data from this study ... to determine the full impact of these HLA-G variants in perinatal HIV-1 transmission. Declaration of competing interests The author(s) declare that they have no...

Ngày tải lên: 10/08/2014, 05:20

... the CRP inflammatory cycle was also raised by Brendon Coventry as a possib ility for patient selection with respect to timing of administration and targeting of therapy, in or der to induce the desired ... inte ract with T cells. Jeffrey Weber therefore designed a system to attract T cells to the injection site and induce in this way and “artificial lymph nodal a...

Ngày tải lên: 11/08/2014, 08:21

... lymphocytes to mobilize specific immunity [1- 4]. By contrast, in order to induce T cell-tolerance in the thymus, DCs present self peptide-MHC complexes to thy- mocytes [5]. The capacity of DCs to initiate ... of regulatory T cells that control activated T cells through their suppressive signals. In addi- tion, DCs play an important role in innate immunity by...

Ngày tải lên: 11/08/2014, 10:23

... fully consistent pat- tern when comparing the family transmission and the case-control approach which makes it unlikely that any of the tested SNPs is already an important functional variant. The ... laboratory anal- ysis, did statistical analysis and wrote the report. J.A. did the clinical survey, C.B. did the SNP analysis, M.B. built serum and DNA bank and did the vita...

Ngày tải lên: 12/08/2014, 16:20

... relative to the hypothesis that apoptosis of DC induced by HIV and/ or migration of mature DC into the lymph node. The function of DC was impaired accompanying with the decline of cell number. Both ... chroni- cally HIV-infected patients [32,37]. The IFN-a mainly secreted by pDC exerts a strong anti-HIV activity not only directly, b ut also indirectly through the act...

Ngày tải lên: 13/08/2014, 01:20