Báo cáo y học: " The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference" pps
Báo cáo y học: " The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference" pps
... caused by direct RNAi-inhibition of the reporter transcript, and not by targeting of the incoming RNA genome. Discussion We have not observed RNAi-mediated targeting of the HIV-1 RNA genome of incoming ... contrast, RNAi directed against the incoming genome could not reduce the transduction effi- ciency. Given the size of the RISC complex, it is lik...
Ngày tải lên: 13/08/2014, 09:20
Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps
... the inactivation signal. He discussed a hypothesis, first proposed by Mary Lyon a few years ago, that repression may occur more efficiently on the X chromosome as a result of its high density ... glycosylases, is essential for embryonic develop- ment. TDG removes the pyrimidines from G:T or G:U mis- matches that occur by deamination of cytosine or 5-methyl cytosine, respectively....
Ngày tải lên: 14/08/2014, 16:20
Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... membrane hyper- polarization and the sensation of light (reviewed in [1]). The sensitivity of the system requires that the signal transmitted by R* be rapidly attenuated. This is accomplished by a ... molecules simultaneously. It may be that only monomeric arrestin is able to effectively interact with R*P, and that the arrestin dimer is a storage form of the protein [14]...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity pot
... that they first bind to several specific binding sites (receptors) on the presynaptic membrane [6], after which they are presumably endocytosed. In the nerve cell, they may inhibit the recycling ... Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia; 2 Department of Biochemistry and Molecular Biology and 3 Mass Spectromet...
Ngày tải lên: 31/03/2014, 08:20
Báo cáo y học: "The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease" pot
... 17:95-103. 14. Benya PD, Padilla SR: Modulation of the rabbit chondrocyte phenotype by retinoic acid terminates type II collagen synthe- sis without inducing type I collagen: the modulated phenotype differs ... release the MM. (e) The partial meniscectomy has been com- pleted and the cut edge of the MM can be seen. Note that in order to visualise the cut edge of the meniscu...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "The mechanism of low-concentration sodium nitroprusside-mediated protection of chondrocyte deat" pps
... calculated by taking the optical density of cells post-treatment, dividing this by the optical den- sity of the untreated control cells, and multiplying by 100. Cell death was also verified by flow cytometry. ... chondrocyte death. We cannot rule out the role played by NO in SNP-mediated chondrocyte death, because it is not possible to quench the NO produced by SNP t...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "The relationship between cancer and rheumatoid arthritis: still a large research agenda" ppsx
... immune modulating therapies in RA may also underlie the observed reduction in breast cancer incidence, but the mechanism is not clear. The important meta-analysis presented by Smitten and colleagues ... citrullinated peptide antibody status and malignancy. Is the risk of lymphoma primarily seen in certain subgroups? This risk might be magnified by specific genetic risk allel...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" pps
... homeo- stasis of the adult vascular system. Another study from the same group showed that blood homeostasis in adult mice is mostly maintained by PHD-2 but can be further modulated by the combined ... and PHD-3. The enzymes were also identified and described by other groups on the basis of similarity to mammalian procollagen prolyl-4-hydroxylase. The expression of PHD isof...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: "The role of patient expectations in predicting outcome after total knee arthroplasty" ppsx
... recovery was 4.7 ± 2.8 months; in reality, by the 2-year follow-up only 80% of the patients actu- ally considered themselves fully recovered from the operation, and they recalled that it had taken them, ... state whether they would choose to undergo the procedure again if they found themselves in the same situation, knowing what they now know about the outcome (yes, definitely;...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: " The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis" pps
... fibrosis is context-depen- dent. Baseline fibrosis is increased in CAT2-deficient mice as measured by the whole lung hydroxyproline assay [8]. Interestingly, this baseline fibrosis is not evident ... Company, St. Louis, MO) according to established techniques [16-18]. Cytokine levels Cytokine levels were determined by Multiplex analysis on BALF supernatant samples. Analysis was...
Ngày tải lên: 12/08/2014, 11:22