Báo cáo y học: " Distinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections" pot

... more increased in early SIVmac infection than in SIVagm infection. SIVmac itself might dysregulate the TGF-β1 signaling cascade by interacting directly or indirectly with Smad molecules. Indeed, ... Central Page 1 of 6 (page number not for citation purposes) Retrovirology Open Access Short report Distinct expression profiles of TGF-β1 signaling mediators in pa...

Ngày tải lên: 13/08/2014, 09:20

... broad-spectrum proinflammatory cytokine with a pivotal role in the regulation of innate and adaptive immune responses [5]. There is increasing evidence for a role of MIF as a proinflammatory cytokine in autoimmune ... IFN-γ and TNF-α) secreted by peripheral blood mononuclear cells (PBMC) were determined by ELISPOT assay. Lymphocytes and monocytes were examined flow- cytometrical...

Ngày tải lên: 09/08/2014, 10:20

... and miRanda. To further increase the prediction accuracy, PITA takes into account the local accessibility of the potential binding sites, whereas miRanda and PicTar apply a different strategy: ... significantly lower levels but shows significantly higher inhibitory activity in ER - cancer, strongly indicating that the differential regulatory effects of miRNAs can not be explained b...

Ngày tải lên: 09/08/2014, 20:20

... in human RBCs encoding initiation, activation and regulation of transcription and translation (for instance RNA polymerises I,II,III, zinc/PHD finger- DNA-binding proteins, cysteinyl, lysyl-tRNA ... expression profiling of human erythrocyte could be an important key for under- standing the machinery of anucleate protein synthesis and its meaning in the pathophysiology of...

Ngày tải lên: 03/11/2012, 10:58

... shown in previous studies [10,11], analysis of gene expression profiles by processing whole homogenized joints can provide useful information about dysregulated genes, not only in synoviocytes ... are given in Fig. 6); I, intensity of gene expression (L = low intensity [0–500], M = medium intensity [500–1500], H = high intensity [1500–4000]). A line (_) in the Delta or P ce...

Ngày tải lên: 09/08/2014, 06:22

... overview of the phylogeny and diversity of eukaryotes. J Systematics Evol 2008, 46:263-273. 2. Yoon HS, Hackett JD, Ciniglia C, Pinto G, Bhattacharya D: A molecular timeline for the origin of photosynthetic ... conditions of ecological rele- vance to increase the probability of obtaining unique gene expression profiles and to study the conditions in which they are induced....

Ngày tải lên: 09/08/2014, 20:22

... the expression of SPP1 and CREBBP genes involved in the transforming growth factor (TGF-b) pathway was down 16-fold. Expression levels of TNFSF10, BCL2L1, SPP1, and CREBBP were also examined by ... The BH3-only domain proteins BIK and BNIP3, which were located upstream of BCL-2 (Figure 2), may enhance their binding to BCL-2, thereby inhibiting the anti-apop- totic function....

Ngày tải lên: 10/08/2014, 21:23

... Symptom Inventory: an introductory report. Psychol Med 1983, 13(3):595-605. 15. Morlan KK, Tan SY: Comparison of the Brief Psychiatric Rating Scale and the Brief Symptom Inventory. J Clin Psychol ... mea- sures anxiety (e.g., nervousness or shakiness inside), depression (e.g., feeling lonely), and general somatic symptoms (e.g., fe eling weak in parts of your body) using a 5-point s...

Ngày tải lên: 11/08/2014, 16:22

... 1 and 2A, and Supplemental Table 2). IRF-7 has been studied extensively in viral infection [27] and can induce the gene expressions of interferon and cytokine [28]. Interestingly, an over- expression ... IL-13 by theophylline may be through the cAMP pathway and further inhibits the expression of LTC4 and LTD4. Conclusion These data may facilitate the understanding of t...

Ngày tải lên: 12/08/2014, 18:22

... glycoprotein; Mal, myelin and lymphocyte protein; Mobp, myelin oligodendrocyte basic protein; Mog, myelin oligodendrocyte glycoprotein; Nnat, neuronatin; Plp1, proteolipid protein (myelin) 1; Sox2, ... oligonucleotide microarrays to gain gene expression profiles of Nfia -/- mouse brains and of corresponding wild-type samples. Relatively early and late changes in gene expres...

Ngày tải lên: 14/08/2014, 07:21