Báo cáo y học: "PAC in FACTT: Time to PAC it in" ppt
Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations." pps
... located in the intracytoplasmic tail. Theinhibitory receptor has a long tail containing immunoreceptortyrosine inhibitory motifs, whereas the activating receptor hasa short tail without this ... KIR3DL1 inhibitoryreceptor, the only KIR known to recognise HLA-B alleles. It binds to HLA-B with serological-defined epitope Bw4 (deter-mined by amino acid positions 79–83 of the molecule) [7] withan ... isoleucine at position 80 (Bw4-I80) [8]. The interaction ofKIR3DL1 and Bw4-I80 has an inhibitory effect on the cytotoxiccapacity of NK cells. All HLA-B27 subtypes carry Bw4epitope, with the...
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Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations" potx
... HLA-B27 by KIR orILT could influence their immunomodulatory function and mayimply a role in inflammatory disease.Binding of the KIR3DL1 receptor to the Bw4 family of MHCclass I receptors has ... KIR3DL1 in combination with HLA-B*27s/HLA-B Bw4-I80 genotypesmay modulate the development of AS. The susceptibility to AScould be determined by the overall balance of activating andinhibitory composite ... could be deter-mined by the overall balance of activating and inhibitory com-posite KIR-HLA genotypes. Further analysis of NKRexpression on T cells in patients with AS may help to elucidatethe...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc
... one year after he finished taking temozolomide. This shouldprovide further insight into a possible toxicity profile of this alkylating agent. This finding should be of interest to physicians in ... oralabsorption, it spontaneously hydrolyzes to methyltria-zen-1-yl imidazole-4-carboxamide (MTIC). MTICdegrades to a highly reactive cation that methylates gua-nines in DNA at the O6 position, causing ... reactivity with Pan-T-markers(that is, CD5, CD7, and cytoplasm cCD3, along withCD45). Positivity of this population with Tdt was alsovery prominent, so immunophenotypic results were con-sistent with...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx
... cells with bright reactivity with Pan-T-markers(that is, CD5, CD7, and cytoplasm cCD3, along withCD45). Positivity of this population with Tdt was alsovery prominent, so immunophenotypic results ... aspiraterevealed diffuse infiltration with blast cells consistentwith acute leukemia. Peripheral blood flow cytometry onimmunophenotyping with five-color cytomics (fc500Beckman Coulter flow cytometer) showed ... known to be active against a var iety of CNS neoplasms. After oralabsorption, it spontaneously hydrolyzes to methyltria-zen-1-yl imidazole-4-carboxamide (MTIC). MTICdegrades to a highly reactive...
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Báo cáo y học: "Improved lung preservation relates to an increase in tubular myelin-associated surfactant protein A" ppsx
... CharlesRiver, Sulzfeld, Germany) received pentobarbital intra-peritoneally (Nembutal 1 mg/kg body weight), were intu-bated by tracheostomy, and heparinized via the vena cavainferior. Animal experiments ... min) was followed by a50-min reperfusion via the pulmonary artery with Krebs-Henseleit-buffer (8.0 ml/min at 37°C) containing bovinered blood cells (hematocrit of 38 to 40%) using a quattrohead ... lamellar bodies for SP-A in the present study.The increased labelling density of tubular myelin for SP-Aafter IR was paralleled by an increase in the total amountof tubular myelin, which was highest...
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Báo cáo y học: "How can the response to volume expansion in patients with spontaneous respiratory movements be predicted" ppsx
... studyindicates that the capacity of ∆PP to predict changes in car-diac index during fluid challenge is inaccurate in the presenceof spontaneous respiratory movements.Spontaneous respiratory ... ± 0.13 for inspiratory changes in RAP, p notsignificant compared with ∆PP).Conclusion In patients with spontaneous respiratorymovements, ∆PP and inspiratory changes in RAP failed to predict ... [15,16]used this index only when patients were able to generateinspiratory efforts sufficient to decrease PAOP by 2 mmHg. In our study, only four patients had respiratory efforts insufficientFigure...
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Báo cáo y học: "Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate" pot
... because it is affected by the GFR and by factorsindependent of the GFR, including age, sex, race, body size,diet, certain drugs, and laboratory analytical methods [2].Rather, the Working Group ... the MDRD equation would probably grantmore clinically useful information to assess AKI.LetterAcute kidney injury: time to shift from creatinine to the estimatedglomerular filtration rate?Giuseppe ... based on an absolute increase in serumcreatinine ≥0.3 mg/dl (≥26.4 μmol/l), a percentage increase in serum creatinine ≥50% (1.5-fold from baseline), or areduction in urine output (documented...
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Báo cáo y học: "Misdiagnosis and undiagnosis due to pattern similarity in Chinese medicine: a stochastic simulation study using pattern differentiation algorithm" pdf
... similarity is intrinsic to Chinese medical knowl-edge (Table 1). Consequently, continued research isnecessary for discovery of strategies for dealing withsimilarity as a confou nding factor. ... pattern-dataset similarity andpattern d ifferentiation outcome within each tested com-bination of the Four Examinations, indicating that anincrease in similarity is accompanied by an increase in misidentification ... quantity of terms in the dataset separated bycomma with case-insensitive letters according to theFour Examinations. Manifestations were described speci-fically including onset (’palpitation in...
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Báo cáo y học: "Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis" pptx
... Crude mortality (%) Predicted mortality (%) ICU mortality (odds ratio (95% confidence interval))Hospital mortality (odds ratio (95% confidence interval))ICU Hospital APACHE II APACHE III Crude ... Evaluation (APACHE) II and APACHE III scoring sys-tems [26]. The definitions regarding pre-existing co-morbidi-ties, primary diagnostic categories, and acute kidney injury arepresented in Additional ... ratios(ORs) with 95% confidence intervals (CIs). Standardized mor-tality ratios were calculated by the ratio of observed inhospitaldeath to predicted inhospital mortality by the APACHE IIscore....
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Báo cáo y học: "Contribution of transcriptional regulation to natural variations in Arabidopsis" ppsx
... domain-containing protein contains INTERPRO:IPR000008 C2 domain14274_at At5g20980 emb|CAB38313.1| 5-Methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase - like protein16 PROTEIN ... jacalin-related mannose-binding lectinfrom salt-stressed rice (Oryza sativa) plants. Planta 2000,210:970-978.24. Kagaya Y, Ohmiya K, Hattori T: RAV1, a novel DNA-bindingprotein, binds to bipartite ... TIR-NBS-LRR class, enzymesinvolved in secondary metabolism, and proteins involved in detoxification.Organ-specific gene expression in different accessions In addition to identifying accession-specific...
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