... is synthesized in the cardiacmyocytes in response to hemodynamic stress [1] orinflammatory status [2]. Over the last d ecade, some stu-dies have indicated that NT-proBNP testing greatlyincreased ... M, Mizuno Y, Shimasaki Y, Nakayama M, Yasue H, Kuwahara K, Saito Y, Nakao K: Effect of interleukin-1 beta on cardiac hypertrophy and production of natriureticpeptide in rat cardiocyte culture. ... Advances in measuring the effect of individualpredictors of cardiovascular risk: the role of reclassification measures.Ann Intern Med 2009, 150:795-802.27. Pencina MJ, D’Agostino RB Sr, D’Agostino...