Báo cáo y học: "Deficient mitochondrial biogenesis in critical illness: cause, effect, or epiphenomeno" pps

... focus on increasing and restoring wild-type mtDNA to restore cellular oxidative capacity and organ function in sepsis and shock. What is most exciting is that we are still gaining insight into this ... and maintain viability by down-regulating oxygen consumption, energy requirements and ATP demand [15,16]. In the heart this response is called myocardial hibernation and results in cardio...

Ngày tải lên: 13/08/2014, 08:20

... decrease mortality during sepsis, especially as splanchnic hypoper- fusion and hypoxia are said to be key factors in the develop- ment of systemic inflammatory response syndrome, sepsis and multiple organ ... contradictory results concerning this, with some reporting decreased mortality in older animal studies [11] and newer meta-analyses [12,13] and others reporting increased mortality...

Ngày tải lên: 13/08/2014, 18:22

... tyrosine kinase-2 to the receptor complex (for review [4,5]). Receptor engagement leads to phosphorylation of tyrosine residues in the cytoplasmic domain of gp130. Phosphotyrosine within the YxxQ ... model gained much support from investigators in arthritis research, and so for more than a decade much effort focused on investigating the molecular basis of inflammatory arthritis induced i...

Ngày tải lên: 09/08/2014, 01:23

... in efficiency are due to an increase in initial library com- plexity arising from better annealing efficiencies of the Illumina adapter. This is probably explained by the fact that Illumina adaptor sequences ... prepared for solid sequencing and one additional library was prepared for both the Illumina * Correspondence: agibbs@bcm.edu 1 Human Genome Sequencing Center, Baylor College of M...

Ngày tải lên: 09/08/2014, 20:22

... in 1900 by the German physician Plettner, who coined the term Kalkaneussporn (calcaneal spur) [1]. Although initially considered to be an abnormal finding inextricably linked to heel pain, more ... enthesis, which may have impli- cations for the management of chronic heel pain in older people. Competing interests HBM and KBL are Editor -in- Chief and Deputy Editor -in- Chief, respectivel...

Ngày tải lên: 10/08/2014, 21:23

... understand Correspondence: p.cuijpers@psy.vu.nl Pim Cuijpers, professor of Clinical Psychology, EMGO Institute, VU University Amsterdam and VU University Medical Center, Department of Clinical Psychology ... to the reasons for seeking treatment or not. Research from the patients’ perspective is also necessary to meet the currently unmet informat ion needs of patients, including information...

Ngày tải lên: 11/08/2014, 15:22

... The major finding of this pilot study is that vitamin D status in female Soldiers declines during mili- tary training in the summer and early autumn months in the Southeastern US. This finding was ... serum 25-hydroxyvitamin D and (B) parathyroid hormone levels in female Soldiers pre- and po st-basic combat training by ethnicity. Serum 25-hydroxyvitamin D, 25(OH)D; parathyroid hormone...

Ngày tải lên: 11/08/2014, 23:21

... lung injury [12]. Pentoxifylline administration to patients with ischemic cardiomyopathy inhibited pro- inflammatory cytokines and reduced apoptosis by decreasing TNF-α and Fas concentrations in ... of cytokines (e.g., TNF-α) and of other proinflammatory inflammatory mediators in the lung, whereas the intrinsic pathway can be triggered after reperfusion by the release of reactive oxygen ....

Ngày tải lên: 12/08/2014, 15:21

... used in the afore- mentioned study, thus possibly explaining this apparent discrepancy. Fascin is a 55 kD protein that binds actin, organising it into well ordered bundles thus contributing to ... were morphologically described as usual interstitial pneumonia by the presence of typical modifications. These included patchy interstitial fibrosis alternating with normal or minimally affected...

Ngày tải lên: 12/08/2014, 16:20

... of continuing research, monitoring of informed consent, monitoring of adherence to approved protocols and monitoring the integrity of data. These activities are intended as means of quality assurance ... Director, Interdepartmental Division of Critical Care Medicine, Professor of Medicine, Surgery and Biomedical Engineering, University of Toronto, Toronto, Canada Correspondence: James V Lav...

Ngày tải lên: 12/08/2014, 20:20