Báo cáo y học: "Activated protein C: cost-effective or costly" pot

Ngày tải lên: 13/08/2014, 01:20

... based exclusively on non-RCTs, when RCT data is available, since Commentary Activated protein C: cost-effective or costly? Savtaj Singh Brar 1 and Braden J Manns 2,3 1 Department of Surgery, University of ... patients using propensity score analysis, though, patients in this study treated with APC still had slightly higher organ failure scores (p = 0.067), and this in part may explain...

Ngày tải lên: 13/08/2014, 08:20

... previous study from our laboratory showing that it caused lethality in C57BL/6 mice which could be delayed by eliminating signalling via the proinflammatory recep- tor for advanced glycation end ... lipopolysaccharide; KC: keratinocyte-derived chemokine; MIP- 2: macrophage inflammatory protein- 2; MPO: myeloperoxidase; PAA: plasmi- nogen activator activity; PAI-1: plasminogen activator inhib...

Ngày tải lên: 13/08/2014, 20:21

... respect to ventilator-free days, mortality or lung injury score [4]. A trial of a recombinant tissue factor pathway inhibitor in patients with severe community-acquired pneumonia demon- strated ... Ltd Activated protein C for H1N1 in uenza? More work to do! Steven P LaRosa* See related research by Schouten et al., http://ccforum.com/content/14/2/R65 COMMENTARY *Correspondence: slaros...

Ngày tải lên: 13/08/2014, 20:22

... Sequential Organ Failure Assessment score as the primary outcome – failed to show any benefi t. In acute pancreatitis, severity is defi ned by the occur- rence of organ failure and /or peri-pancreatic ... III) system shows that nonsurvivors in SAP have signifi cantly lower levels of protein C and AT III activity, and higher levels of D-dimer and plasminogen activator inhibitor-1, than sur-...

Ngày tải lên: 13/08/2014, 21:21

... study, the more organ failures, the hig her was the mortality in both groups. Across all organ failure subgroups (one, two, three, four, or five organ failure subgroups), in-hospital mortality ... this study is made stronger by the propensity-matched analysis. Our pri- mary outcome was in-hospital mortality, and rhAPC began to show i ts effect in the ICU (Table 3). ICU mor- tality comes ......

Ngày tải lên: 14/08/2014, 07:21

... pathway, the inflammatory process, monocyte TF expres- sion, and mortality. Competing interests The authors declare that they have no competing interests (aPC was provided by Eli-Lilly). Authors' ... our study. This assessment is not easily obtained in rabbit. During laparotomy for abdominal aorta extraction, we did not observe any organ haematomas or haemorrhage. We did not see any di...

Ngày tải lên: 12/08/2014, 23:22

... ELISA [enzyme-linked immunosorbent assay] kits (R&D Systems GmbH, Wiesbaden-Nordenstadt, Germany) according to the manufacturer's instructions. Statistical analysis Data analysis was performed ... which a systemic response to an infection mediated by endogenous mediators leads to a gen- eralised inflammatory reaction in organs remote from the initial insult and eventually to organ dy...

Ngày tải lên: 13/08/2014, 03:20

... for meningococcal purpura fulminans. Lancet 1998, 351:986-987, author reply 988. 19. Hodgson A, Ryan T, Moriarty J, Mellotte G, Murphy C, Smith OP: Plasma exchange as a source of protein C for ... of two days for non-survivors and a median of nine days for survi- vors (P < 0.0001). The duration of mechanical ventila- tion was a median of 6.5 d ays for those who survived. Survivors were ....

Ngày tải lên: 13/08/2014, 21:21

... years, a previous knee injury requiring non-weight bearing treatment for > 24 h or surgery (including arthroscopy), or a history of any form of arthritis diagnosed by a medical practitioner. ... preceding 3 months: an acute psychiatric illness; acute renal, liver, cardiovascular disease or any other acute major illness; gynecological surgery; active malignancy or can- cer treatment...

Ngày tải lên: 09/08/2014, 10:23