Báo cáo y học: " Corticosteroids to prevent postextubation upper airway obstruction: the evidence mount" doc

... volume) to define and study patients at high risk for postextubation UAO. Patients randomly assigned to methylprednisolone (40 mg every 6 hours for four doses) were less likely either to experience stridor ... than 36 to 48 hours receive such therapy? Although a short course of corticosteroids may be relatively safe, further study is warranted. This author believes the focus sho...

Ngày tải lên: 13/08/2014, 08:20

... inflammatory mediators, increase of cytokines and free radicals probably due to hypoxic injury of the atelectatic lung may be involved in pathogenesis of RPE [6,8-11]. More than one century ago, ... inflamma- tion in the lungs, and PMNLs play an important role in the mechanism of the increase in pulmonary microvascu- lar permeability. An animal study has shown that PMNLs and pro-inf...

Ngày tải lên: 10/08/2014, 10:20

... postoperati ve pulmon- ary dysfunction CPB may not b e the only factor contributing, but other factors related to the cardiac operation such as anaesthesia, temporary cardiac dys- function, infused ... several leukocyte depletion filters, used in cardiac surgery. They concluded that: a) whilst the filters did not appear to significantly lower leukocyte count, they may preferen- tial...

Ngày tải lên: 10/08/2014, 10:20

... presum- ably based on its anti-inflammatory actions, which inhibit the release of inflammatory mediators and decrease capillary per- meability. The risk of harm from steroid therapy for 24 hours ... blinded. The ICU physicians were not apprised of the measurements obtained by the respi- ratory therapist. On the day preceding extubation, dexametha- sone or placebo was administered...

Ngày tải lên: 13/08/2014, 03:21

... http://ccforum.com/content/12/4/167 Abstract Myocardial edema is a hallmark of ischemia-reperfusion-related cardiac injury. Ischemia-reperfusion has been shown to result in degradation of the endothelial glycocalyx. The glycocalyx is the ... glycocalyx loss may alleviate fluid leakage and edema formation in hearts undergoing occlusion and subsequent reperfusion [1]. The glycocalyx:...

Ngày tải lên: 13/08/2014, 11:22

... influenced by environmental factors [10]. Even if the causal mutations are common in the population, their effects will, therefore, be difficult to discover. As the effects of any given SNP may be modest, ... becoming ill, and to use genetic information to tailor drug therapy. The purpose of this review is to put some of the predictable consequences of the advances in geno...

Ngày tải lên: 12/08/2014, 18:21

... persistent pulmonary hypertension of the newborn due to cytokine elaboration, acidosis and hypoxia in the setting of sepsis [52]. These underlying differences in anatomy, physio- logy and adaptive ... anti-inflammatory response syndrome, the resultant exaggerated inflammatory response leads to increased morbidity and mortality during sepsis [14]. The concentration of proinflammato...

Ngày tải lên: 13/08/2014, 08:20

... B deoxycholate (0.7 mg/kg per day intravenously). At first glance, the efficacy of combi- nation therapy was slightly superior to that of monotherapy (success: 69% versus 56%), especially in patients ... voriconazole, respectively. Efficacy of and/or tolerance to voriconazole may be affected by great variability in blood levels caused by nonlinear pharmacokinetics, polymorphism of cytoc...

Ngày tải lên: 13/08/2014, 08:21

... anti-inflammatory cytokines [9]. Typically, IL-6 (which has anti-inflammatory properties) is the first cytokine to rise during exercise, increasing up to 100-fold greater than pre-exercise levels, and then ... reactive oxygen species; TNF = tumor necrosis factor. and automated orders for physical therapy, more patients received physical therapy during their ICU stay (73% in the protoc...

Ngày tải lên: 13/08/2014, 16:20

... Reumatoide Artritis) [57] and a large US combination trial [58], these were among the first to clearly demonstrate that early combi- nation therapy was superior to monotherapy. Similarly, the TICORA ... 6 months, thereby enriching the population with ‘successful patients’ who could tolerate the studied therapy. In addition to potential synergy as well as additive efficacy attrib...

Ngày tải lên: 09/08/2014, 01:22