Báo cáo y học: "Modeling longitudinal data in acute illness" pptx

... decades. Interestingly, critical illness has the potential to become a key testing ground and field of application for these emerging modeling techniques, given the increasing availability of point-of-care ... biomarker profiles should be interpreted remain open fields of inquiry. In this regard, the development of data- driven models that ‘explain’ the dynamics of markers of septic physio...

Ngày tải lên: 13/08/2014, 08:20

... determined using MART change more quickly along the gene than those determined using the Poisson linear model, but in neither case are the changes as drastic as in the original data. Actually, the variance-to-mean ... data should incorporate sequencing preference infor- mation. Particularly, we suggest training a model for sequencing preference using only the top 100 genes and MART, th...

Ngày tải lên: 09/08/2014, 20:22

... interval of the day where the minimum hazard is achieved. Relapse-Free Survival by Timing of Surgery: Hrushesky's DefinitionFigure 4 Relapse-Free Survival by Timing of Surgery: Hrushesky's ... others, to the daily wake/sleep cycle, a yearly seasonal cycle and, in women, the menstrual cycle. Sine/cosine functions are often used to model biological patterns for continuous data, but...

Ngày tải lên: 10/08/2014, 09:20

... Hydrogen bonding modulates binding of exogenous ligands in a myoglobin proximal cavity mutant. Biochemistry 38, 11086–11092. 30. Franzen, S. (2002) Carbonmonoxy rebinding kinetics in h93g myoglobin: ... The data in Fig. 1 suggest that H93G(2-MeIm) may be an excellent example of the effect of strain on the heme iron in a protein model system. The origin of proximal histidine strain...

Ngày tải lên: 08/03/2014, 16:20

... Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan 2. Division of Clinical Laboratory, Yamagata University Hospital, Yamagata, Japan  Corresponding author: Dr. Yoko ... pneumo- nia, infiltrating neutrophils produce pro-inflammatory cytokines and chemokines, result- ing in the induction of cellular adhesion molecules on circulating leukocytes and pulmon...

Ngày tải lên: 08/08/2014, 18:21

... LOC388720are involved in the KEGG (Kyoto Encyclopaedia of Genes and Genomes) ribosome pathway. RPS6 is also involved in the insulin signalling and the mTOR signalling pathway. MCM3 and VIM are involved in ... NME2 negatively reg- ulates Rho activity through interactions with other proteins involved in the Rho pathway [22]. In embryonic mouse lungs, the inhibition of the Rho pathway...

Ngày tải lên: 12/08/2014, 14:20

... shock. Figure 5 Individual changes in mean pulmonary artery pressure (MPAP) and PaO 2 /FiO 2 induced by increasing inspiratory intratracheal concentrations of inhaled NO (Insp IT NO) in eight patients ... dopamine, epine- phrine or norepinephrine tend to reinforce hypoxic pulmonary vasoconstriction. In the present study, patients with circulatory shock receiving vasodilating inotrops...

Ngày tải lên: 12/08/2014, 18:20

... pathogenesis of acute lung injury in humans. The first of these, namely the ‘neutrophilic hypothesis’, suggests that during acute inflammation the cytokines granulocyte colony-stimulating factor and granulocyte/macrophage ... mediated by soluble factors, primarily the proinflammatory cytokines granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor (GM...

Ngày tải lên: 12/08/2014, 19:22

... Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol 1984, 117:273-285. 20. Rich S: Primary pulmonary hypertension. ... expiratory pause of 10 s was imposed during data acquisition. During data acquisition, patients breathing spontaneously were instructed to maintain a relaxed expiratory pause of a...

Ngày tải lên: 12/08/2014, 20:21

... and results in cardiomyocyte hypocontractility with preserved cellular ATP [15]. Hibernating cells maintain ATP levels in the setting of defective oxidative phosphorylation by ceasing nonessential cellular ... recent data make it clear that cells can adapt and maintain viability by down-regulating oxygen consumption, energy requirements and ATP demand [15,16]. In the heart this respon...

Ngày tải lên: 13/08/2014, 08:20