Báo cáo y học: "Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig" potx
Báo cáo y học: "Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig" potx
... CentralPage 1 of 5(page number not for citation purposes) Cough Open AccessResearchInhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pigSum Yee ... cough. However, capsaicin- and citric acid -cough were not completely inhibited by V112220. The incomplete inhibition, particularly of cap-saicin-induced cough may indicate that higher dose of V112220 ... as iodo-resinifera-toxin and BCTC that have shown inhibition of cough induced by citric acid and capsaicin in the guinea-pig[14,15].Number of coughs following citric acid or capsaicin exposureFigure...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... of urokinase expression and Invasiveness by urinary trypsin inhibitor is mediated through inhibition of proteinkinase C- and MEK/ERK/c-Jun – dependent signaling pathways.J. Biol. Chem. 276, ... maintenance of tumor cell growth[3]. The finding that the ERK signaling pathway is involved in tumor cell migration and invasion [4,5], as well as in tubular formation induced by insulin in human ... g and theresulting pellet was transferred to a scintillation vial. Theradioactivity was determined by liquid scintillationcounting.Determination of c-mycgene expression by RT-PCRanalysisSerum-starved...
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Báo cáo y học: "Inhibition of human immunodeficiency virus type-1 by cdk inhibitors" pdf
... Tat-associated kinase, is a member of thecyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocyticcell lines. Proc ... phorylation of the hyper-phosphorylated RNA Pol II [20]. In kinase assays, Tatinduces phosphorylation of CTD by cdk9, whichrequires the N-terminal domain ( amino acids 1 to 48) and the arginine-rich ... cell cycle reg-ulatory proteins in HIV-1 infected cells, we determinedthe levels of cdk2, cycl in E, cyclin A, a nd other kinases by western blot analysis. As shown in Figure 3A, thelevels of...
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Báo cáo Y học: Fusion of farnesyldiphosphate synthase and epi-aristolochene synthase, a sesquiterpene cyclase involved in capsidiol biosynthesis in Nicotiana tabacum docx
... fusions of FPPS and ADS and introduce the bifunctional enzyme into plants of A. annua.We expect to obtain an increased biosynthesis of artemisinin in transgenic plants of A. annua expressing the ... I.M. (1988) Coordinated inhibition of squalene synthetase and induction of enzymes of sesquiterpe-noid phytoalexin biosynthesis in cultures of Nicotiana tabacum.Phytochemistry 27, 2567–2580.18.Mercke,P.,Crock,J.,Croteau,R.&Brodelius,P.E.(1999)Cloning, ... epi-aristolochene synthase;farnesyl diphosphate synthase; gene fusion; recombinantexpression.The enzymatic machinery of a living cell is very complex.Thousands of enzymes are present and the flow of metabolites...
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Báo cáo y học: " Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus Enterotoxin B in mice" pps
... non-organized lymphoidaggregates (Figure 7).Since CXCL13, CCL19 and CCL21 are chemokinesinvolved in the homeostatic trafficking of leukocytes,mainly lymphocytes, to the secondary and tertiary lym-phoid ... werecollected.Results: Combined exposure to CS and SEB resulted in a raised number of lymphocytes and neutrophils in BAL, aswell as increased numbers of CD8+T lymphocytes and granulocytes in lung tissue, ... [4]. In nasal polyp disease, these t oxins arebelieved to drive the local immunoglobulin production in response to enterotoxin-producing S. aureus.TheuseofasingletoxininsteadofS. aureus in thismodel...
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Báo cáo y học: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study" pps
... cells.Results: In our study TNFα was the initial and predictive cytokine released followed by IL-6, CXCL8 and IL-10 in the cytokine cascade following LPS exposure. The cytokine cascade was inhibited by theneutralisation ... associ-ated with increased airway inflammation[17,18].Cytokines such as IL-6 and CXCL8 are rarely producedindividually instead they are more usually released in combination with other cytokines and mediators ... exaggerated inflammatoryresponse[3]. Indeed the activation and infiltration of inflammatory cells including (CD8+) T lymphocytes,macrophages and neutrophils is a prominent feature of COPD[4,5]. In addition...
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Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... heparin-binding region of antithrombin. However, such binding did not stimulate theactivity of antithrombin as did heparin and heparan; in fact,it blocked the ability of antithrombin to inhibit ... liver.The inhibitory activity of antithrombin on thrombin is signifi-cantly enhanced by heparin, a type of glycosaminoglycan(GAG) [8]. The GAG family comprises large anionicpolysaccharides ... conducted to investigate the effects of HA and several other glycosaminoglycans on antithrombin, aplasma inhibitor of thrombin. Various glycosaminoglycans,including HA, chondroitin sulfate,...
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... wasreduced by 60% in the presence of 500 lMCl-tetracycline and by 95% in t he presence of 500 lMerythromycin and streptomycin (Fig. 2B,C). Tetracycline at 500 lMinhibitedsplicing by only 1 0% ... splicing apparatus. The inhibitoryeffect of erythromycin and Cl-tetracycline were not allevi-ated by Mg2+(Fig. 3).Kinetic analyses using increasing concentrations of erythromycin, Cl-tetracycline ... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by thesubstitution,...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... the culture medium was quantitated by asandwich binding protein assay using a very specific HABP(Fig. 3). By 8 h of culturing, a small amount of HA releasedinto the culture medium was observed, ... pathogenicity by allowingthem to escape from the immune systems of their hosts.The HA synthesized by Streptococci is not chemicallyor structurally distinguishable from that synthesized in mammalian ... obtained using culturedhuman skin fibroblasts. It seems likely therefore that themechanisms of inhibition of HA synthesis by MU are verysimilar if not identical between eukaryote and prokaryotecells.Cell-free...
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Báo cáo Y học: Formation of conjugated D11 D13-double bonds by D12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds doc
... preference against linoleicacid in the presence of a-linolenic acid. This problem may besolved by using this new type of (1,4)-acyl-lipid-desaturasethat converts a double bond located only in the ... since this class of enzymes seem to catalyze an(1,4)-elimination of hydrogen atoms bound to the aliphaticcarbon chain instead of an 1,2-syn elimination in case of theclassical acyl-lipid-desaturases ... encoding a protein of 387 amino acids. For functional identification proteinsencoded by the cDNAs were expressed in Saccharomycescerevisiae, and formation of newly formed fatty acids wasanalyzed...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Tranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM