Báo cáo y học: "Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig" potx

... Central Page 1 of 5 (page number not for citation purposes) Cough Open Access Research Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig Sum Yee ... cough. However, capsaicin- and citric acid -cough were not completely inhibited by V112220. The incomplete inhibition, particularly of cap- saicin-induc...

Ngày tải lên: 13/08/2014, 08:20

... of urokinase expression and Invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun – dependent signaling pathways. J. Biol. Chem. 276, ... maintenance of tumor cell growth [3]. The finding that the ERK signaling pathway is involved in tumor cell migration and invasion [4,5], as well as in tubular formation induced by...

Ngày tải lên: 21/02/2014, 01:21

... Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines. Proc ... phorylation of the hyper- phosphorylated RNA Pol II [20]. In kinase assays, Tat induces phosphorylation of CTD by cdk9, which requires the N-terminal domain ( amino acids...

Ngày tải lên: 10/08/2014, 05:21

... fusions of FPPS and ADS and introduce the bifunctional enzyme into plants of A. annua. We expect to obtain an increased biosynthesis of artemisinin in transgenic plants of A. annua expressing the ... I.M. (1988) Coordinated inhibition of squalene synthetase and induction of enzymes of sesquiterpe- noid phytoalexin biosynthesis in cultures of Nicotiana tabacum. Phytoc...

Ngày tải lên: 24/03/2014, 03:21

... non-organized lymphoid aggregates (Figure 7). Since CXCL13, CCL19 and CCL21 are chemokines involved in the homeostatic trafficking of leukocytes, mainly lymphocytes, to the secondary and tertiary lym- phoid ... were collected. Results: Combined exposure to CS and SEB resulted in a raised number of lymphocytes and neutrophils in BAL, as well as increased numbers of CD8 + T...

Ngày tải lên: 12/08/2014, 13:22

... cells. Results: In our study TNFα was the initial and predictive cytokine released followed by IL-6, CXCL8 and IL-10 in the cytokine cascade following LPS exposure. The cytokine cascade was inhibited by the neutralisation ... associ- ated with increased airway inflammation[17,18]. Cytokines such as IL-6 and CXCL8 are rarely produced individually instead they are more usually rel...

Ngày tải lên: 12/08/2014, 15:21

... heparin-binding region of antithrombin. However, such binding did not stimulate the activity of antithrombin as did heparin and heparan; in fact, it blocked the ability of antithrombin to inhibit ... liver. The inhibitory activity of antithrombin on thrombin is signifi- cantly enhanced by heparin, a type of glycosaminoglycan (GAG) [8]. The GAG family comprises large anionic po...

Ngày tải lên: 09/08/2014, 06:22

... was reduced by 60% in the presence of 500 l M Cl-tetracycline and by 95% in t he presence of 500 l M erythromycin and streptomycin (Fig. 2B,C). Tetracycline at 500 l M inhibited splicing by only 1 0% ... splicing apparatus. The inhibitory effect of erythromycin and Cl-tetracycline were not allevi- ated by Mg 2+ (Fig. 3). Kinetic analyses using increasing concentrations...

Ngày tải lên: 21/02/2014, 15:20

... the culture medium was quantitated by a sandwich binding protein assay using a very specific HABP (Fig. 3). By 8 h of culturing, a small amount of HA released into the culture medium was observed, ... pathogenicity by allowing them to escape from the immune systems of their hosts. The HA synthesized by Streptococci is not chemically or structurally distinguishable from that synth...

Ngày tải lên: 08/03/2014, 09:20

... preference against linoleic acid in the presence of a-linolenic acid. This problem may be solved by using this new type of (1,4)-acyl-lipid-desaturase that converts a double bond located only in the ... since this class of enzymes seem to catalyze an (1,4)-elimination of hydrogen atoms bound to the aliphatic carbon chain instead of an 1,2-syn elimination in case of the cla...

Ngày tải lên: 08/03/2014, 16:20