Báo cáo y học: "TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs" pps

... decrease in capsaicin-induced cough of 31%. In ovalbumin passively sensitized guinea pigs, we found that BCTC (1 and 3 mg/kg, i.p.) attenuated antigen ovalbumin (0.3%) cough responses by 27% and ... respectively. We conclude that TRPV1 channel activation may play role in cough mediated by antigen in sensitized guinea pigs. Our results supports increasing evidence tha...

Ngày tải lên: 13/08/2014, 08:20

... Sinoff G, Ore L, Zlotogorsky D, Tamir A: Short Anxiety Screening Test - a brief instrument for detecting anxiety in the elderly. Int J Geriatr Psychiatry 1999, 14:1062-1071. 25. American Psychiatric ... screening tool, within primary care settings. Thus the SAST could be used to obtain preliminary information with regard to anxiety symptoms, which would then need to be followed-up by a deta...

Ngày tải lên: 08/08/2014, 23:21

... transcription in human monocytes. Blood 1997, 89:4461. 10. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation ... X, Kubin M, Trinchieri G: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in acces...

Ngày tải lên: 09/08/2014, 01:21

... differences in immune parameters such as cytokine and antibody responses and clinical scores when disease was induced with suboptimal doses of aggrecan, clearly revealing genetic drift in the colonies ... the susceptible mouse strain BALB/c. Although induction of disease by the usual immunisation regime did not reveal any differences in incidence and severity, the sub-lines of BALB/c mi...

Ngày tải lên: 09/08/2014, 14:20

... carbapenems it has a relatively long half-life due to high protein binding capacity, permitting once daily administration [30]. The in vitro activity of ertapenem is retained against most isolates that ... with the following in mind: in addition to the specificity of antimi- crobial agent for the offending microorganism, its distri- bution within the body is a critical factor in deter...

Ngày tải lên: 11/08/2014, 03:20

... strongly affected by the inflammatory process and ultimately this interferes with bone mechanical performance. In addition, scanning electron microscopy findings showed that SKG mice exhibit thinner ... cross-linking telopeptides (CTX-I) and amino-terminal propeptide of type I procollagen (PINP) were measured in serum. The organization and density of bone collagen were analyzed in ver...

Ngày tải lên: 12/08/2014, 11:22

... Biomedicine/Anatomy, University of Helsinki, Biomedicum, Helsinki, Finland. 2 Finnish Institute of Occupational Health, Helsinki, Finland. 3 Laboratory for Clinical Physiology, Helsinki University ... immunity. Methods: Balb/c wildtype (WT), STAT4-/- and STAT6-/- mice were sensitized with intraperitoneally injected ovalbumin (OVA) followed by OVA or PBS airway challenge. Airway hyperreact...

Ngày tải lên: 12/08/2014, 13:22

... can enhance innate immunity by increasing the potency of the natural antimicrobial peptides. In addition to increasing the activity of individual ASL factors, lowering the NaCl concentration also independently ... preparations by using Wright-Giemsa stain. The cell-free fluid was frozen at -70°C until required for cytokine assay. Cytokine measurements were performed using enzyme linked immu...

Ngày tải lên: 12/08/2014, 18:21

... report demonstrating the efficacy of PDE 3 inhibition in view of cough reflex sensitivity in elderly asthmatics. Further stud- ies are required to investigate the role of other PDE iso- zymes in airway cough ... studies in patients with other bronchial disorders and normal subjects. In conclusion, the present study clearly indicates that PDE 3 inhibition can attenuate cough...

Ngày tải lên: 13/08/2014, 08:20

... complained of belch. She was obese with a weight gain of over 10 kg in the last two years. Cough was predominant in the daytime and deteriorated on rising from bed and after eating. Fre- quency Scale ... to 15 years) with cough (> 4 weeks) but found only one with GERD[7]. A later study by Holinger found GERD respon- sible for cough (>4 weeks) in 11 out of 72 infants and chil...

Ngày tải lên: 13/08/2014, 08:20