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Báo cáo y học: "Effectiveness of a Chinese herbal medicine preparation in the treatment of cough in uncomplicated upper respiratory tract infection: a randomised double-blinded placebo-control trial" docx

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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps

... animalReviewIntra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of actionLarry W MorelandUniversity of Alabama at Birmingham, Birmingham, AL, USACorresponding ... OAand RA, intra-articular HA reduced the levels of PGE2[73,74] and stimulated cAMP concentrations, anothermechanism by which HA may act in an anti-inflammatorymanner [74].HA also has antioxidant ... Similarly, HA may alsohelp prevent invasion of inflammatory cells into the jointspace. In acute and chronic inflammatory processes of the joint, the size of HA molecules decreases at the same...
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Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx

... (iodoacetate-induced arthritis) and a pain model (Hargraeves assay).Methods: P38 kinase activity was evaluated in a kinase assay by measuring the amount of phosphorylatedsubstrate ATF2 using a ... degeneration in an animal model of osteoarthritisand are analgesic in an inflammatory pain model. The inhibitory effect of the p38 inhibitors on joint degenera-tion in the iodoacetate model in the ... thermal hyperalgesia in rats when administered intrathecally [10]. These data sug-gest that cytokine inhibition may be useful for treating the pain associated with OA.Monoclonal anti-TNF therapies...
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Báo cáo y học:

Báo cáo y học: "Effectiveness of a Chinese herbal medicine preparation in the treatment of cough in uncomplicated upper respiratory tract infection: a randomised double-blinded placebo-control trial" docx

... purposes) Cough Open AccessResearchEffectiveness of a Chinese herbal medicine preparation in the treatment of cough in uncomplicated upper respiratory tract infection: a randomised double-blinded placebo-control ... (including valvular heart disease), hadconcurrent gastrointestinal symptoms such as nausea,vomiting, abdominal pain or diarrhoea) or if they wereilliterate and had difficulties in filling in the ... significant clin-ical implications for the Chinese population because thisformulary shared many components in commerciallyavailable ready-made TCM preparations in the market(for example, Pei Pa...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan 2. Department of Gastroenterology, Nagoya University Graduate School of Medicine, ... especially cagA positive strains, plays a crucial role in the development of gastric atrophy and cancer [2,3]. CagA/ src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) interaction ... confronting two-pair primers) [19]. The primers were F1: 5’ GGT TTA AAC TTT ATT CTG ACT GTT CCC, R1: 5’ ACA CAA TTT AGT AAT AGC CAA AGT CAA C, F2: 5’ GTT GTT GTG AAG TAG AAA CTG ATT TCT AA, and...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

... inactivation and the temperature at which the enzyme starts inactivating at a measurable rate increasefrom the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor could be the ... of unchargedpolar amino acids (i.e. Q, N, S, and T) and an increase in charged amino-acid residues (i.e. K, E, and R) in hyperthermophilic proteins. As S and T can catalyze the deamination and ... the enzyme. Each metal-containing enzyme was scannedagainst the corresponding dialysis buffer. The dialysisbuffer was used to generate the baseline. The enzymecontaining both Mg2þand Co2þwas...
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Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx

... stress; initiation; elongation factor; mRNAtranslation; S6 kinase. The control of mRNA translation in mammalian cellsinvolves the regulation of a range of components of the translational machinery, ... SDS/polyacrylamide gels containing 15% acryla-mide/0.4% methylene bis-acrylamide. For analysis of eEF2,gels contained 10% (w/v) acrylamide plus 0.1% methylenebis-acrylamide. For analysis of the ... kinase activity using purified eEF2 as substrate. Samples were analysed by SDS/PAGE and autoradiography. The position of the radiolabelled eEF2 on the autoradiograph is indicated. Similar data...
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx

Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx

... Ca2+calmodulin interaction.Amphibians have rich chemica l arsenals that form anintegral part of their defence system, and also assist with the regulation of dermal physiological action. In ... they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1,frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu-rin, but at concen trations ... peptides also inhibit the activity of calcineurin, anotherenzyme that requires the presence of the regulatory proteinCa2+calmodulin. It i s p roposed that the amphibian peptidesinhibit nNOS by interacting...
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Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot

... the majority of these antibodies are of the IgG and IgA class,but that their frequency in SjS sera is not higher than that of the classic autoantibodies directed against the Ro60and La antigens.Analysis ... van den Hoogen FH: The synergistic value of focusscore and IgA% score of sublabial salivary gland biopsy for the accuracy of the diagnosis of Sjogren’s syndrome: a 10-year comparison. Rheumatology ... contain IgA antibodiesagainst α-fodrin (Table 1) and 3 (14%) of the 21 con-tained IgM antibodies against α-fodrin (not shown). Five of the nine primary SjS sera with IgA antibodies to fodrin alsocontained...
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Báo cáo y học: "Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk" docx

... problem.Conveying risk to the patient while allowing them tounderstand the decision-making process leading to the use of the specific therapy remains daunting. The issue of the relative risk for a therapeutic ... comparative studies of these alternativestrategies prevents quantitative comparative assessment of the risk of serious gastrointestinal and cardiovasculardisease. Once again we are reminded that ... orseverity. When only small incremental benefits accrue to patientsfrom the use of a given therapy, on the other hand, even very rareserious events may play a role in decision-making by patients, bytheir...
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Báo cáo y học: "What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years" doc

... biological therapy in RA, thistheory led to the concept of a dual-therapeutic strategy,including anti-inflammatory biological therapy, on one hand,and antineoplastic type drug strategies, including ... concepts and how this has far-reaching implications.How magnetic resonance imaging changed the way we view rheumatoid arthritisJoint failure is the final common pathway of an array of inflammatory, ... crystal, and degenerative arthritis. The advan-tage of seeing patients early in the course of disease is thatabnormalities evident in imaging are likely to be primary ratherthan secondary....
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