DNA Methylation: Basic Mechanisms - Part 8 pdf
DNA Methylation: Basic Mechanisms - Part 8 pdf
... Mol Bi o l4 : 111–12 8 Pau l in RP, Ho T, Ba l zer HJ, Ho ll i d ay R (19 98) Gene si l encing b y DNA met h y l ation an d d ua l in h eritance in C h inese h amster ovary ce ll s. Genetics 149:1 081 –1 088 2 38 O . ... Nat l Aca d Sci USA 95 :87 27 87 3 2 Hollida y R, Pu g h JE (1975) DNA modification mechanisms and g ene activit y durin g develo p ment. Science 187 :226–232 Ja bl...
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DNA Methylation: Basic Mechanisms - Part 1 pptx
... Belozersk y AN, Kokurina NA, Kadirova DX (19 68) 5-Meth y lc y tosine an d 6-met h y l amino-purine in b acteria l DNA. Nature 2 18: 1066–1067 W aa l wij k C, F l ave ll RA (19 78) MspI, an isosc h izomer o f HpaII ... aci d o f t h etu b erc l e b aci ll us . Su b sequent ly , 5-mC h a d a b ioc h emica lf uture as 5- hyd rox y met hyl -C ( 5- h m-C) in the DNA of the T-even bacteri...
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DNA Methylation: Basic Mechanisms - Part 2 ppsx
... b y mutations in X-linked MECP2, encodin g meth y l-CpG- bindin g protein 2. Nat Genet 23: 185 – 188 Ar b er W, Linn S (1969) DNA mo d i fi cation an d restriction. Annu Rev Bioc h em 38: 467 – 500 Bac h man ... interacting d omain; C XX C ,Cys-ric hd omain ; ( E ) 1 2 , G l u repea t; ( GR ) 11 , G l y-Arg repeat; MBD , met h y l -CpG- b in d ing d omain ; Hh H-GPD,DN A N-Gl y cos y lase d...
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DNA Methylation: Basic Mechanisms - Part 3 pptx
... ompose d o f small g ene-rich re g ions intermixed with 5- to 200-kb blocks of repetitiv e DNA. The repetitive DNA blocks are usuall y meth y lated at 5 - CG -3 a n d5 - C NG-3 c ytosines in ... o d i fi cations 83 2.6 RNA-Directed DNA Meth y lation 86 2.7 Biolo g ical Role of C y tosine DNA Meth y lation 9 0 3 Adenine DNA Meth y latio n 9 7 3.1 N 6 -Met h...
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DNA Methylation: Basic Mechanisms - Part 4 ppsx
... mouse m y o g enic g ene M y o-D1. Gene 151 :89 –95 Kimura H, Shiota K (2003) Meth y l-CpG-bindin g protein, MeCP2, is a tar g et molecule for maintenance DNA meth y ltransferase, Dnmtl. J Biol Chem 2 78: 480 6– 481 2 Kinos h ita ... Genetics 165 :83 5 84 8 L uo S, Preuss D (2003) Strand-biased DNA meth y lation associated with centromeri c re g ions in Arabidopsis. Proc Natl Acad Sci...
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DNA Methylation: Basic Mechanisms - Part 5 pot
... wor kp rocee d e d (Doer fl e r 1 981 , 1 983 , 1995, 1996, 2000; Doerfler et al. 1 988 , 2001) . T h e d iscovery o f 5-mC (Hotc hk iss 19 48) in eu k aryotic, particu l ar l yin mammalian, DNA has provoked a challen g in g search ... non-5 -CG -3 C-residues were never meth y lated. Around exon 1 of the S NRPN g ene, more t h an 96% o f t h e23 5 - CG - 3 - d inuc l...
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DNA Methylation: Basic Mechanisms - Part 6 pps
... Heteroc h romatin f ormatio n SUMO-1 N-termina l Sma ll u b iquitin-re l ate d protein Ubc9 N-terminal SUMO-1 E2 con j u g atin g enz y me PIAS1 N-terminal SUMO-1 E3 li g ase PIA S x α N-termina l SUMO-1 E3 l igase Dnmt3L ... RA R β . PML-RAR-induced re p ression of RAR β t ranscription was partia ll yre l ease db y 5-aza- d C, in d icating t h at DNA met h y - lation contributes to the...
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DNA Methylation: Basic Mechanisms - Part 7 docx
... Mechanism of DNA- (Cytosine-C5)-MTase s The reaction mechanism of c y tosine-C5 meth y lation was uncovered for th e prokar y otic DNA- (c y tosine-C5)-MTase M.HhaI (Fi g . 2; Wu and Santi 1 985 ; Wu an d Santi ... 1 , 287 59 Bremen, German y a. j eltsch@iu-bremen.de 1In t r oduct i o n 2 04 2Cata l ytic Mec h anism o f DNA- (Cytosine-C5)-MTases . 20 6 2.1 Reaction Mec h anism o f DNA...
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DNA Methylation: Basic Mechanisms - Part 9 pps
... s induced b y (± )-7 b,8a - d ih y drox y -9 a,10a-epox y -7 ,8, 9,10-tetrah y drobenzo[a]p y rene in the codin g re g ion of t h e HPRT gene. Proc N at l Aca d Sci USA 87 :86 80 86 8 4 Coulondre C, ... Inst 91 :86 88 Barbacid M (1 987 ) ras g enes. Annu Rev Biochem 56:779 82 7 Bentivegna SS, Bresnic k E (1994) In h i b ition o fh uman O6-met h y l guanine-DN A m et h y l trans...
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DNA Methylation: Basic Mechanisms - Part 10 pot
... (pro l ine-tryptop h an- tr y ptophan-proline ) do m a in 1 85 py rimidine dimer 25 9 R b 18 9 r epet i t i ve sequence 72, 88 r ep l ication 67, 68, 75–77, 80 , 88 –90, 9 5, 99 – 102 , 18 4 r ep l ication f or k 213 r ep l icativ ... 18 1 M AR see matrix attac h men t r e g ions matrix attachment re g ions 3 5 MBD see m eth y l-CpG-bindin g d omain MBD 1 30, 32, 18 8 MBD 2 28, 30–...
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