DNA Methylation: Basic Mechanisms - Part 6 pps
DNA Methylation: Basic Mechanisms - Part 6 pps
... Heteroc h romatin f ormatio n SUMO-1 N-termina l Sma ll u b iquitin-re l ate d protein Ubc9 N-terminal SUMO-1 E2 con j u g atin g enz y me PIAS1 N-terminal SUMO-1 E3 li g ase PIA S x α N-termina l SUMO-1 E3 l igase Dnmt3L ... RA R β . PML-RAR-induced re p ression of RAR β t ranscription was partia ll yre l ease db y 5-aza- d C, in d icating t h at DNA met h y - lation contributes to the...
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DNA Methylation: Basic Mechanisms - Part 2 ppsx
... Strat l ing WH (1997) C h ic k en MAR- b in d ing protein ARBP is h omo l ogous to rat m et h y l -CpG- b in d ing protein MeCP2. Mo l Ce ll Bio l 17: 565 6 – 566 6 Won g E, Yan g K, Kura g uchi M, ... Sequences ? 55 4.1 C h romatin-Base d Targeting 5 6 4.2 Targeting o f DNMTS b yDNA-Boun d TranscriptionFactors 5 9 4.3 T h eRNATrigger 6 0 5C onclusion s 62 R e f e r e n ces 63 A b...
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DNA Methylation: Basic Mechanisms - Part 4 ppsx
... Ka d irova DX (1 968 ) 5-Met h y l cytosine and 6- meth y laminopurine in bacterial DNA. Nature 218:1 066 –1 067 V an y us h in BF, T k ac h eva SG, Be l ozers ky AN (1970) Rare b ases in anima l DNA. Nature 22 5: 9 4 8 – 9 4 9 V an y ushin ... Lymp h oma an d Leu k emia Ce ll Lines an d in Norma l Human Lymp h ocytes 1 56 6 .10 T h ePromotero f t h e Human 5 -( CGG ) n - 3 ...
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DNA Methylation: Basic Mechanisms - Part 9 pps
... is DNA repair. Th e p resence o f 5-met h y l cytosine may a ff ect t h e sequence- d epen d ent repair of DNA adducts. A 5-meth y lc y tosine base at the 5 -position a dj acent to an O6-meth y l g uanine ... s induced b y (± )-7 b,8a - d ih y drox y -9 a,10a-epox y -7 ,8,9,10-tetrah y drobenzo[a]p y rene in the codin g re g ion of t h e HPRT gene. Proc N at l Aca d Sci USA...
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DNA Methylation: Basic Mechanisms - Part 1 pptx
... I Introduct i on 18 W. D oe rfl e r V an y ushin BF, Belozersk y AN, Kokurina NA, Kadirova DX (1 968 ) 5-Meth y lc y tosine an d 6- met h y l amino-purine in b acteria l DNA. Nature 218:1 066 –1 067 W aa l wij k C, F l ave ll RA (1978) MspI, an ... Information 23 g roupsint h eDNAare f oun d at t h e C 5 p osition o f cytosines giving ris e t o 5-meth y lc y tosine (5mC) or at N 6 p osit...
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DNA Methylation: Basic Mechanisms - Part 3 pptx
... o d i fi cations 83 2 .6 RNA-Directed DNA Meth y lation 86 2.7 Biolo g ical Role of C y tosine DNA Meth y lation 9 0 3 Adenine DNA Meth y latio n 9 7 3.1 N 6 -Met h y l a d enine in DNA o f Eu k aryotes ... 2003). The DNA meth y lase inhibitors 5-azaC y t and 5-aza- 2 -deox y c y tidine inhib - ite d a d ventitious s h oot in d uction in Petun i a l ea f cu l tures. C y t...
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DNA Methylation: Basic Mechanisms - Part 5 pot
... non-5 -CG -3 C-residues were never meth y lated. Around exon 1 of the S NRPN g ene, more t h an 96% o f t h e23 5 - CG - 3 - d inuc l eoti d es were met h y l ate d on t h emater - na l c h romosome, ... Gene s Th e5 - CG - 3 -rich promoter re g ion of the DNA- dependent RNA pol y merase I (rDNA) g enes was ana ly ze df or t h e presence o f 5-mC nuc l...
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DNA Methylation: Basic Mechanisms - Part 7 docx
... German y a. j eltsch@iu-bremen.de 1In t r oduct i o n 2 04 2Cata l ytic Mec h anism o f DNA- (Cytosine-C5)-MTases . 20 6 2.1 Reaction Mec h anism o f DNA- (Cytosine-C5)-MTases 2 06 2.2 Base Flippin g ... of DNA- (C y tos i ne-C5)-MTase s A ll DNA MTases use t h e coenz y m e S- a d enos yl- l - met h ionine ( A d oMet ) as t he s ource f or t h e met h y l group b eing trans f...
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DNA Methylation: Basic Mechanisms - Part 8 pdf
... o f ce ll cyc l e proteins E2F-1, C dk -2 , Cy- c l in E, p27( k ip1), an d Ki -6 7 in norma l p l acenta an d gestationa l trop h o bl astic d i sease. M od P at h o l14 : 1 0 36 –1 0 4 2 O zalp S, Yalcin ... 24:20 9 –218 E l-Maarri O (2004) SIRPH anal y sis: SNuPE with IP-RP-HPLCfor quantitativemeasure- ments of DNA meth y lation at specific CpG sites. Methods Mol Biol 287:195–20 5 El...
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DNA Methylation: Basic Mechanisms - Part 10 pot
... 72 , 81 , 86 , 87 , 91 , 92 , 94– 96 , 26 0 m utator transposon 77, 95 M yc 19 1 N on-CG Met h y l ation 211 n on-CpG s i te 18 2 n uclear DNA 72 , 73 , 76 , 10 1 n ucleolar dominance 85 , 86 n ucleosome ... biolo g ical in- terpretation of non-random abundance in the E. coli K-12 g enome of tetra- and p entanucleotide se q uences related to VSP DNA mismatch re p air. Nucleic Aci...
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