DNA Methylation: Basic Mechanisms - Part 2 ppsx
DNA Methylation: Basic Mechanisms - Part 2 ppsx
... Neuro l 28 :20 5 21 1 C hen RZ, Akbarian S, Tudor M, Jaenisch R (20 01) Deficienc y of meth y l-CpG bindin g protein -2 in CNS neurons results in a Rett-like phenot y pe in mice. Na t Gene t 2 7:3 2 7 – 331 Ch en ... of MeCP2. Science 3 02: 885–889 C huan g LS, Ian HI, Koh TW, N g HH, Xu G, Li BF (1997) Human DNA- (c y tosine-5 ) meth y ltransferase-PCNAcomplex as a tar g et forp21WAF1....
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DNA Methylation: Basic Mechanisms - Part 4 ppsx
... Jacobsen SE (20 03 ) Role of the DRM and CMT3 meth y ltransferases in RNA-directed DNA meth y la- tion. C urr Biol 13 :22 12 22 1 7 Casti lh oA,NevesN,Ru fi ni-Castig l ione M, Viegas W, Hes l op-Harrison ... Vira l Genomes 13 3 2. 2.1 Man y DNA Virion Genomes Are Unmeth y lated, Others Are Meth y lated . . 133 2. 2 .2 SYREC , an Ad 12 Recombinant Genome T hat Carries Unmeth y latedCel...
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DNA Methylation: Basic Mechanisms - Part 1 pptx
... A. 2 1 C ar d oso , M. C. 2 1 Ch en, T. 17 9 Doer fl er , W. 3 , 125 El-Maarri, O. 22 9 Fu k s, F. 45 Ho ll i d ay , R. 24 3 J eltsch, A. 20 3 L eon h ar d t , H. 2 1 Li , E. 179 P feifer,G.P. 25 9 S l im , R. ... 179 P feifer,G.P. 25 9 S l im , R. 22 9 V an y us h in, B. F. 67 W alsh, C. P. 28 3 X u ,G .L. 28 3 22 A. Br e r oeta l . s i bl e f or d e fi ning a ce ll ty...
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DNA Methylation: Basic Mechanisms - Part 3 pptx
... Whitham 20 01; Vaucheret and Fa g ard 20 01; Bourc’his and Bestor 20 02 ; K a k utani 20 02; Li et a l . 20 02; Wassenegger 20 02; Liu an d Wen d e l 20 03; Sto k e s 2 003; Vinkenoo g et al. 20 03; Matzke ... Specificit y 7 0 2. 2 .2 A g eSpecificit y 7 1 2. 2.3 Cellular (Tissue) Specificit y 71 2. 2.4 Su b ce ll u l ar (Organe ll e) Speci fi city 7 1 2. 2.5 Intragenome Speci...
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DNA Methylation: Basic Mechanisms - Part 5 pot
... h y bridizatio n t o 32 P - l a b e l e d A d 12 DNA or, more speci fi ca ll y, to t h e 32 P - l a b e l e d termina l f ra g ments o f A d 12 DNA. In t h is wa y ,t h e termina l vira l DNA f ra g ments l in k e d t o ... Ad2-transformed cell line HE2, the E2A promoter in t h e integrate d A d 2 genome is h eavi l y met h y l ate d not on l yina ll 5 - CG -3...
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DNA Methylation: Basic Mechanisms - Part 6 pps
... Heteroc h romatin f ormatio n SUMO-1 N-termina l Sma ll u b iquitin-re l ate d protein Ubc9 N-terminal SUMO-1 E2 con j u g atin g enz y me PIAS1 N-terminal SUMO-1 E3 li g ase PIA S x α N-termina l SUMO-1 E3 l igase Dnmt3L ... reporter assa y s (Aapola et al. 20 02; Bachman et a l . 20 01; De pl us et a l . 20 02; Fu k seta l . 20 00, 20 01; Ro b ertson et a l . 20 00; Roun- tree et al....
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DNA Methylation: Basic Mechanisms - Part 7 docx
... 1 , 28 759 Bremen, German y a. j eltsch@iu-bremen.de 1In t r oduct i o n 2 04 2Cata l ytic Mec h anism o f DNA- (Cytosine-C5)-MTases . 20 6 2. 1 Reaction Mec h anism o f DNA- (Cytosine-C5)-MTases ... Je l tsc h 20 02 ) . 2 .1 Reaction Mechanism of DNA- (Cytosine-C5)-MTase s The reaction mechanism of c y tosine-C5 meth y lation was uncovered for th e prokar y otic DNA- (c y tos...
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DNA Methylation: Basic Mechanisms - Part 8 pdf
... si l encing b yen d ogenous DNA met h y l ation . Proc Nat l Aca d Sci USA 95:8 727 –873 2 Hollida y R, Pu g h JE (1975) DNA modification mechanisms and g ene activit y durin g develo p ment. Science 187 :22 6 23 2 Ja bl on k aE,Lam b MJ ... SNuPE with IP-RP-HPLCfor quantitativemeasure- ments of DNA meth y lation at specific CpG sites. Methods Mol Biol 28 7:195 20 5 El -Maarri O, He...
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DNA Methylation: Basic Mechanisms - Part 9 pps
... transver sions b y 5- f ormy l uraci l in mamma l ian ce ll s. Muta t R es 513 :21 3 22 2 K ami y a H, Tsuchi y a H, Karino N, Ueno Y, Matsuda A, Harashima H (20 02b) Muta - g enicit y of 5-form y lc y tosine, ... 16: 124 1– 124 7 D iNoiaJ,Neuber g er MS (20 02) Alterin g the pathwa y of immuno g lobulin h y permuta- tion b y inhibitin g uracil -DNA g l y cos y lase. Nature 419:43–4...
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DNA Methylation: Basic Mechanisms - Part 10 pot
... mo l e s – b iparenta l comp l ete h y d ati d i f orm m o l es 23 4 – C HM 23 1, 23 2, 23 4, 23 5 – complete h y datidifor m mo l es 2 3 4 – familial 22 9 , 23 1 23 3 , 23 5 23 7 – G NA S 1 2 33 – H 1 9 23 5 – partial h y datidiform moles 23 1 – PHM 23 1 – ... re g ions 2 33 , 23 6 –DMR 23 3 23 5 – level 23 3 , 23 4 , 23 6 – mat ernall y meth y lated 23 3, 23 4 –...
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