BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... 257–8 IL-1 232–5 IL-1a 232–3 IL-1Ra 234 IL-1b 232–3 IL-2 224, 225–32 IL-3 235–6, 257–8 IL-4 224, 236–8 IL-5 241–3 IL-6 238–40 IL -1 0 224 IL-11 240–1 IL-12 244–6 IL-13 224 IL-18 224 International ... effects 203–7 biotechnology 207 10 IFN-a 122, 196, 197–8, 210 13, 520–6 IFN-b 122, 196, 197, 198, 213–14 IFN-g 196, 197, 198, 214–16, 278 IFN-g 1B 216 IFN-o 219 IFN-t 219 JAK–STAT pathway 202–...
Ngày tải lên: 13/08/2014, 07:20
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... preparations, however, are only partially purified and modern preparations are generally subjected to additional high-resolution chromatographic fractiona- tion (Figure 10. 1). Ion-exchange chromatography ... BIOPHARMACEUTICALS Figure 10. 8. Outline of the production strategy of CEA-SCAN. The antibody-producing hybridoma cell line was originally obtained by standard methods of hybridoma...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... therapeutic 8 BIOPHARMACEUTICALS Interleukin-1 (IL-1) 232 The biological activities of IL-1 233 IL-1 biotechnology 234 Interleukin-3: biochemistry and biotechnology 235 Interleukin-4 236 Interleukin-6 238 Interleukin-11 ... anaphylaxis Adrenal gland BIOPHARMA CEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY Second Edition Gary Walsh Industrial Biochemistry Programme CES Department U...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... broad-spectrum antibiotic to be discovered, and was found effective against Gram- negative and Gram-positive bacteria, rickettsias and chlamydias. It retains activity when administered orally and ... only a sub-group of the standard tests for chemical-based drugs are appropriate. Biopharmaceuticals pose several particular difficulties, especially in relation to pre-clinical toxicologic...
Ngày tải lên: 13/08/2014, 07:20
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... Sciences, Ireland The media constituents, several of which are heat-labile, are generally dissolved in WFI and filter-sterilized into the pre-sterile animal cell reactor. Reactor design (and operation) ... Follicle-stimulating hormone (FSH) CHO Insulin E. coli Interferon-b CHO Erythropoietin CHO Interferon-a E. coli Glucocerebrosidase CHO Interferon-g E. coli Factor VIIa BHK Interleukin-2 (...
Ngày tải lên: 13/08/2014, 07:20
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein Molecular mass (kDa) IFN-a 20–27 TNF-a 52* EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20–25 G-CSF 21 Insulin 5.7 IL-2 15–20 EPO 36 hGH 22 IL-1 17.5 TPO 60 FSH 34 IL-12 30–35 IGF-1 7.6 LH 28.5 *Biologically ... (e.g. receptors for IL-8, IL-9 and IL -1 0) . Many contain two polypeptide components (including IL-3, IL-4 and IL-5 receptors), while a few contain three or mo re polypeptide co...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... factors (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL-1, IL-6, IL -1 0, IL-12 Eosinophils IL-3, IL-5 Vascular endothelial cells IL-1, IL-6, IL-8 Fibroblasts ... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells. Its g...
Ngày tải lên: 13/08/2014, 07:20
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 284 BIOPHARMACEUTICALS IGF biochemistry IGF-1 and -2 ... approximately 10 710 M), A ˜ ¼ weaker binding (K d ¼ approximately 10 78 – 10 79 M). – ¼ failure to bind Ligand Receptor (R) IGF-I IGF-II Insulin IGF-I R A ˜ A ˜ A ˜ A ˜ A ˜...
Ngày tải lên: 13/08/2014, 07:20
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... between days 40 and 130 of gestation. 336 BIOPHARMACEUTICALS Box 8.6. The androgens and oestrogens The androgens and oestrogens represent the major male and female sex hormones, respectively. The ... common a-subunit and a unique b-subunit. The b-subunit shows less homology to that of other members of the group. It consists of 118 amino acids, is particularly rich in cysteine resi...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of single-stranded RNA (ssRNA) of approximately 5–8 kb. Upon entry into sensitive cells, the viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse- quently integrates ... lipids and polylysine Additional viruses that may prove of some use as future viral vectors include adeno- associated virus and herpes virus. Adeno-associated virus is a very s...
Ngày tải lên: 13/08/2014, 07:20