BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx

... its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies. Br. J. Anaesth. 88 (6), 84 8 86 3. Thrombolytics Al-Buhairi, A. & Jan, M. (2002). Recombinant ... Blood 84 (3), 680 – 686 . Collen, D. (19 98) . Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent. Nature Med. 4(3), 279– 284 . Collins, R. et al. (1997). Drug therapy—a...

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... 2 78 approved biopharmaceuticals 11, 502–3 haemopoietic growth factors 257 8 IL-1 232–5 IL-1a 232–3 IL-1Ra 234 IL-1b 232–3 IL-2 224, 225–32 IL-3 235–6, 257 8 IL-4 224, 236 8 IL-5 241–3 IL-6 2 38 40 IL-10 ... 440 anti-haemophilic factor 359 anti-inflammatories 20 a 2 -antiplasmin 383 , 388 anti-sense technology 4, 11–12, 488 –95 antisera 403, 404, 405 antistatin 377 antithrombin 374, 379...

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... therapeutic 8 BIOPHARMACEUTICALS Interleukin-1 (IL-1) 232 The biological activities of IL-1 233 IL-1 biotechnology 234 Interleukin-3: biochemistry and biotechnology 235 Interleukin-4 236 Interleukin-6 ... 277 Insulin-like growth factors (IGFs) 279 IGF biochemistry 280 IGF receptors 280 IGF-binding proteins 282 Biological effects 282 IGF and fetal development 283 IGFs and...

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... broad-spectrum antibiotic to be discovered, and was found effective against Gram- negative and Gram-positive bacteria, rickettsias and chlamydias. It retains activity when administered orally and ... Pharmaceutical biotechnology. Curr. Opin. Biotechnol. 10, 525–527. Walsh, G. (2000). Biopharmaceutical benchmarks. Nature Biotechnol. 18, 83 1 83 3. Walsh, G. (2002). Biopharmaceuticals...

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... Sciences, Ireland The media constituents, several of which are heat-labile, are generally dissolved in WFI and filter-sterilized into the pre-sterile animal cell reactor. Reactor design (and operation) ... industrial-scale centrifuges. Photos courtesy of Alfa Laval Separation AB, Sweden 1 38 BIOPHARMACEUTICALS product, but their pH values could change quite dramatically when cooled from...

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... Protein Molecular mass (kDa) IFN-a 20–27 TNF-a 52* EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20–25 G-CSF 21 Insulin 5.7 IL-2 15–20 EPO 36 hGH 22 IL-1 17.5 TPO 60 FSH 34 IL-12 30–35 IGF-1 7.6 LH 28. 5 *Biologically ... (e.g. receptors for IL -8 , IL-9 and IL-10). Many contain two polypeptide components (including IL-3, IL-4 and IL-5 receptors), while a few contain three or mo re polypeptide co...

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... (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL-1, IL-6, IL-10, IL-12 Eosinophils IL-3, IL-5 Vascular endothelial cells IL-1, IL-6, IL -8 Fibroblasts ... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells. Its growth...

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... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 284 BIOPHARMACEUTICALS IGF biochemistry IGF-1 and -2 ... paracrine- and autocrine-based activity. In the human female, IGF-1 is expressed by follicular theca cells, while IGF-2 is synthesized by granulosa cells (Chapter 8) . The IGF-...

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... levels of PMSG and secrete it into the blood, where it is detectable between days 40 and 130 of gestation. 336 BIOPHARMACEUTICALS Box 8. 6. The androgens and oestrogens The androgens and oestrogens ... common a-subunit and a unique b-subunit. The b-subunit shows less homology to that of other members of the group. It consists of 1 18 amino acids, is particularly rich in cysteine...

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... consists of single-stranded RNA (ssRNA) of approximately 5 8 kb. Upon entry into sensitive cells, the viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse- quently integrates ... lipids and polylysine Additional viruses that may prove of some use as future viral vectors include adeno- associated virus and herpes virus. Adeno-associated virus is a very...

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