BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells. Its growth and differentiation-inducing effects ... factors (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL-1, IL-6, IL-10, IL-12 Eosinophils IL-3, IL -5 Vascular en...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... therapeutic 8 BIOPHARMACEUTICALS Interleukin-1 (IL-1) 232 The biological activities of IL-1 233 IL-1 biotechnology 234 Interleukin-3: biochemistry and biotechnology 2 35 Interleukin-4 236 Interleukin-6 238 Interleukin-11 ... 452 Adjuvant technology 453 Adjuvant mode of action 455 Mineral-based adjuvants 455 Oil-based emulsion adjuvants 455 xiv CONTENTS BIOPHARMA CEUTICALS B...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... resistance. J. Intern. Med. 252 (2), 91–106. Tudzynski, P. et al. (2001). Biotechnology and genetics of ergot alkaloids. Appl. Microbiol. Biotechnol. 57 (5 6), 59 3–6 05. Walsh, C. (2002). Combinatorial ... broad-spectrum antibiotic to be discovered, and was found effective against Gram- negative and Gram-positive bacteria, rickettsias and chlamydias. It retains activity when admi...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... Sciences, Ireland The media constituents, several of which are heat-labile, are generally dissolved in WFI and filter-sterilized into the pre-sterile animal cell reactor. Reactor design (and operation) ... Follicle-stimulating hormone (FSH) CHO Insulin E. coli Interferon-b CHO Erythropoietin CHO Interferon-a E. coli Glucocerebrosidase CHO Interferon-g E. coli Factor VIIa BHK Interleukin-2 (...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein Molecular mass (kDa) IFN-a 20–27 TNF-a 52 * EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20– 25 G-CSF 21 Insulin 5. 7 IL-2 15 20 EPO 36 hGH 22 IL-1 17 .5 TPO 60 FSH 34 IL-12 30– 35 IGF-1 7.6 LH 28 .5 *Biologically ... (e.g. receptors for IL-8, IL-9 and IL-10). Many contain two polypeptide components (including IL-3, IL-4 and IL -5 receptors), while a few contain three or mo re pol...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... well as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin 4 /5 (NT-4 /5) and neurotrophin-6 (NT-6). All are small, basic proteins sharing approximately 50 % amino acid ... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 284 BIOPHARMACEUTICALS IGF biochemistry...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... concentrated form ( 15 25% protein) or as an isotonic solution (4 5% protein). In both cases, in excess of 95% of BLOOD PRODUCTS AND THERAPEUTIC ENZYMES 355 Chinese hamster ovary (CHO) cells and baby hamster ... properties. Adv. Drug Delivery Rev. 54 (4), 50 5 53 0. Ikegami, H. & Ogihara, T. (1996). Genetics of insulin-dependent diabetes mellitus. Endocr. J. 43(6), 6 05 613. Johnso...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... for details a-Galactosidase and urate oxidase Recombinant a-galactosidase and urate oxidase represent two additional biopharmaceuticals recently approved for general medical use. a-Galactosidase ... single-chain 432 amino acid glycoprotein displaying four oligosaccharide side-chains and an approximate molecular mass of 58 kDa. It is present in plasma at concentrations of 150 mg/ml a...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of single-stranded RNA (ssRNA) of approximately 5 8 kb. Upon entry into sensitive cells, the viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse- quently integrates ... 69– 75. Perkus, M. et al. (19 95) . Poxvirus-based vaccine candidates for cancer, AIDS and other infectious diseases. J. Leukocyte Biol. 58 , 1–10. Plotkin, S. (2002). Vaccine...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... 257 –8 IL-1 232 5 IL-1a 232–3 IL-1Ra 234 IL-1b 232–3 IL-2 224, 2 25 32 IL-3 2 35 6, 257 –8 IL-4 224, 236–8 IL -5 241–3 IL-6 238–40 IL-10 224 IL-11 240–1 IL-12 244–6 IL-13 224 IL-18 224 International ... 318 insulin-dependent diabetes mellitus 304, 3 05 insulin glargine 3 15, 318 insulin-like growth factors (IGF-1 and IGF-2) 278, 279– 85, 298, 3 25, 327, 331 Insulin Lispro 3 15, 318, 319...
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