BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein
Molecular
mass (kDa)
IFN-a 20–27 TNF-a 52* EGF 6
IFN-b 20 GM-CSF 22 NGF 26
IFN-g 20–25 G-CSF 21 Insulin 5.7
IL-2 15–20 EPO 36 hGH 22
IL-1 17.5 TPO 60 FSH 34
IL-12 30–35 IGF-1 7.6 LH 28.5
*Biologically ... (e.g.
receptors for IL-8, IL-9 and IL-10). Many contain two polypeptide components (including
IL-3, IL -4 and IL-5 receptors), while a few contain three or mo re polypeptide co...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... fibrin strands, thus
dissolving the clot. tPA and plasminogen both bind to the surface of fibrin strands (b), thus ensuring rapid
and efficient activation of the thrombolytic process
41 6 BIOPHARMACEUTICALS
Table ... 1 84 and 44 8). The carbohydrate moieties play an important role in mediating hepatic
uptake of tPA and hence its clearance from plasma. It is normally found in the blo...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... 257–8
IL-1 232–5
IL-1a 232–3
IL-1Ra 2 34
IL-1b 232–3
IL-2 2 24, 225–32
IL-3 235–6, 257–8
IL -4 2 24, 236–8
IL-5 241 –3
IL-6 238 40
IL-10 2 24
IL-11 240 –1
IL-12 244 –6
IL-13 2 24
IL-18 2 24
International ... 212–13
immunoglobulin 40 6, 40 7
monoclonal antibodies 43 4
surface antigen (HBsAG) 13, 122, 44 1, 44 4
vaccine 43 7, 44 0 , 44 1
hepatitis C 212, 352
hepatitis D 212
Hercep...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... 238
Interleukin-11 240
Interleukin-5 241
Interleukin-12 244
Tumour necrosis factors (TNFs) 246
TNF biochemistry 246
Biological activities of TNF-a 247
Immunity and inflammation 248
TNF receptors 249
TNF: ... therapeutic
8 BIOPHARMACEUTICALS
Interleukin-1 (IL-1) 232
The biological activities of IL-1 233
IL-1 biotechnology 2 34
Interleukin-3: biochemistry and biotechnology...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... Prod. Rep. 14( 1), 75–82.
Hancock, R. (1997). Peptide antibiotics. Lancet 349 (9 049 ), 41 8 42 2.
Kalant, H. (1997). Opium revisited— a brief review of its nature, composition, non-medical use and relative ... biosynthesis of antibiotics, challenges and opportunities. Chembiochem. 3(2–3),
125–1 34.
PHARMACEUTICALS, BIOLOGICS AND BIOPHARMACEUTICALS 41
Peptide and other antibioti...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... & Co Ltd from Walsh & Headon (19 94)
Particulate matter Soil particles
Dirt particles
Particles derived from decaying organic matter, such as leaves
Particles derived from leaching of internal ... Sciences,
Ireland
The media constituents, several of which are heat-labile, are generally dissolved in WFI and
filter-sterilized into the pre-sterile animal cell reactor. Reactor design (a...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co-
stimulatory roles in the maturation of the range of blood cells.
Its growth and differentiation-inducing effects ... factors (CSFs) and platelet-derived growth factor (PDGF)
Cell type Interleukins produced
Macrophages IL-1, IL-6, IL-10, IL-12
Eosinophils IL-3, IL-5
Vascular endothe...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes
increased expression of FSH and LH receptors in ovarian tissue.
2 84 BIOPHARMACEUTICALS
IGF biochemistry
IGF-1 and -2 ... family.
They include NGF, as well as brain-derived neurotrophic factor (BDNF), neurotrophin-3
(NT-3), neurotrophin 4/ 5 (NT -4 / 5) and neurotrophin-6 (NT-6). All are small, b...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... mass 64 kDa. It consists
of two a-chains ( 141 amino acids) and two b-chains ( 146 amino acids), with each subunit
displaying an associated haem prosthetic group. The interaction of the oxygen-binding ... 615.
Combettes-Souverain, M. & Issad, T. (1998). Molecular basis of insulin action. Diabet. Metab. 24, 47 7 48 9.
Conrad, B. et al. (19 94) . Evidence for superantigen involvement in...
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of
single-stranded RNA (ssRNA) of approximately 5–8 kb. Upon entry into sensitive cells, the
viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse-
quently integrates ... (BSA),
used as a carrier to ensure an immunological response).
44 4 BIOPHARMACEUTICALS
Figure 10. 14. Photographs illustrating some clean room-based processing equipment utilize...