BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 4 pps
... Protein Molecular mass (kDa) IFN-a 20–27 TNF-a 52* EGF 6 IFN-b 20 GM-CSF 22 NGF 26 IFN-g 20–25 G-CSF 21 Insulin 5.7 IL-2 15–20 EPO 36 hGH 22 IL-1 17.5 TPO 60 FSH 34 IL-12 30–35 IGF-1 7.6 LH 28.5 *Biologically ... (e.g. receptors for IL-8, IL-9 and IL-10). Many contain two polypeptide components (including IL-3, IL -4 and IL-5 receptors), while a few contain three or mo re polypeptide co...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 8 ppsx
... fibrin strands, thus dissolving the clot. tPA and plasminogen both bind to the surface of fibrin strands (b), thus ensuring rapid and efficient activation of the thrombolytic process 41 6 BIOPHARMACEUTICALS Table ... 1 84 and 44 8). The carbohydrate moieties play an important role in mediating hepatic uptake of tPA and hence its clearance from plasma. It is normally found in the blo...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 10 ppsx
... 257–8 IL-1 232–5 IL-1a 232–3 IL-1Ra 2 34 IL-1b 232–3 IL-2 2 24, 225–32 IL-3 235–6, 257–8 IL -4 2 24, 236–8 IL-5 241 –3 IL-6 238 40 IL-10 2 24 IL-11 240 –1 IL-12 244 –6 IL-13 2 24 IL-18 2 24 International ... 212–13 immunoglobulin 40 6, 40 7 monoclonal antibodies 43 4 surface antigen (HBsAG) 13, 122, 44 1, 44 4 vaccine 43 7, 44 0 , 44 1 hepatitis C 212, 352 hepatitis D 212 Hercep...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 1 potx
... 238 Interleukin-11 240 Interleukin-5 241 Interleukin-12 244 Tumour necrosis factors (TNFs) 246 TNF biochemistry 246 Biological activities of TNF-a 247 Immunity and inflammation 248 TNF receptors 249 TNF: ... therapeutic 8 BIOPHARMACEUTICALS Interleukin-1 (IL-1) 232 The biological activities of IL-1 233 IL-1 biotechnology 2 34 Interleukin-3: biochemistry and biotechnology...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 2 potx
... Prod. Rep. 14( 1), 75–82. Hancock, R. (1997). Peptide antibiotics. Lancet 349 (9 049 ), 41 8 42 2. Kalant, H. (1997). Opium revisited— a brief review of its nature, composition, non-medical use and relative ... biosynthesis of antibiotics, challenges and opportunities. Chembiochem. 3(2–3), 125–1 34. PHARMACEUTICALS, BIOLOGICS AND BIOPHARMACEUTICALS 41 Peptide and other antibioti...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 3 potx
... & Co Ltd from Walsh & Headon (19 94) Particulate matter Soil particles Dirt particles Particles derived from decaying organic matter, such as leaves Particles derived from leaching of internal ... Sciences, Ireland The media constituents, several of which are heat-labile, are generally dissolved in WFI and filter-sterilized into the pre-sterile animal cell reactor. Reactor design (a...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 5 doc
... cytokines (including IL-2, -4 , -5 , -6 , -7 , -1 1, -1 5 and CSFs) also play important co- stimulatory roles in the maturation of the range of blood cells. Its growth and differentiation-inducing effects ... factors (CSFs) and platelet-derived growth factor (PDGF) Cell type Interleukins produced Macrophages IL-1, IL-6, IL-10, IL-12 Eosinophils IL-3, IL-5 Vascular endothe...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 6 potx
... increased androgen and oestradiol synthes is by these cells. IGF-1 also promotes increased expression of FSH and LH receptors in ovarian tissue. 2 84 BIOPHARMACEUTICALS IGF biochemistry IGF-1 and -2 ... family. They include NGF, as well as brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin 4/ 5 (NT -4 / 5) and neurotrophin-6 (NT-6). All are small, b...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 7 ppt
... mass 64 kDa. It consists of two a-chains ( 141 amino acids) and two b-chains ( 146 amino acids), with each subunit displaying an associated haem prosthetic group. The interaction of the oxygen-binding ... 615. Combettes-Souverain, M. & Issad, T. (1998). Molecular basis of insulin action. Diabet. Metab. 24, 47 7 48 9. Conrad, B. et al. (19 94) . Evidence for superantigen involvement in...
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BIOPHARMACEUTICALS BIOCHEMISTRY AND BIOTECHNOLOGY - PART 9 potx
... consists of single-stranded RNA (ssRNA) of approximately 5–8 kb. Upon entry into sensitive cells, the viral RNA is reverse-transcribed and eventually yields double-stranded DNA. This subse- quently integrates ... (BSA), used as a carrier to ensure an immunological response). 44 4 BIOPHARMACEUTICALS Figure 10. 14. Photographs illustrating some clean room-based processing equipment utilize...
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