Báo cáo y học: "Turning up the volume on mutational pressure: Is more of a good thing always better? (A case study of HIV-1 Vif and APOBEC3)" pot

... G-to -A substitutions (many of these amino acid replacements are not typically associated with resistance, but variation at these sites may impact mutational pathways and modu- late viral susceptibility to antiretroviral ... APOBEC3G is catalytically active and has antiviral potency as a monomer. The monomeric capacity of APOBEC3G makes the range of 3–11 mole- cules per v...

Ngày tải lên: 13/08/2014, 06:20

... disturbances in nutrient absorption, induction of nausea and an increased risk of aspiration [1]. Furthermore, the gut has long been established as an important immune barrier, providing a ... safeguard against infectious complications [3]. For these reasons, tight clinical monitoring of gastrointestinal motility is central in the clinical management of critically ill...

Ngày tải lên: 13/08/2014, 20:22

... alive and breathing without assistance during the 21-day study period (ventilator-free days), time to ICU and hospital discharge, and all-cause 21-day survival. Results During the 21-day study ... Furthermore, daily sedation interruption and early physical therapy may also be benefi cial [8]. Recommendation Taken together, the result of these pilot studies highlight t...

Ngày tải lên: 13/08/2014, 21:21

... resistors at 30% hypovolemia were analyzed by one-way analysis of var- iance and the Tukey test. The relation between the SV and the SPV or PPV was analyzed by linear regression, and the sensi- tivity ... rate, and the airway and esophageal pressures were recorded continuously for later analyses. Blood gases were sampled from the right carotid and the pulmonary a...

Ngày tải lên: 13/08/2014, 16:20

... bloodstream, inducing systemic infl ammatory responses (for example, increased vascular permeability, leukocyte– endothelial adhesion, and activation of complement and clotting pathways) and resulting ... Procalcitonin is another sepsis marker with kinetic characteristics that may allow antici- pation of diagnosis of sepsis 24 to 28 hours before the CRP level [10]. Abe an...

Ngày tải lên: 13/08/2014, 20:22

... precip- itate in study design and data analysis, and helped to draft the manuscript. FP conceived the study, participated in the study design and data analysis, and drafted the manuscript. References 1. ... adjuvant-induced arthritis (AIA). CF101 (IB-MECA), an A 3 AR agonist, was previously found to inhibit the clinical and pathological manifestations of AIA. The...

Ngày tải lên: 09/08/2014, 08:23

... peak effect of bronchodilation. Although we have used a standard method of aerosol delivery and a standard dose, altered respiratory mechanics and small-airway disease in these infants with bronchiolitis ... significance of such a response is unknown. We have only used a single dose of aerosol and measured the pul- monary function once after the aerosol administrat...

Ngày tải lên: 12/08/2014, 18:21

... research grants and/ or material from Edwards Healthcare, LiDCO, and Pulsion. Authors' contributions SH collected the data and contributed to the analysis of the data and writing of the manuscript. ... designed the study collected the data and contributed to the analysis of the data Key messages • Pulse pressure variation and inspiratory variation in RA...

Ngày tải lên: 13/08/2014, 01:20

... determination of intra-abdominal pressure (IAP) [5]. Despite the simplicity of this method, it remains poorly standardized across the published literature. Basic research into the validity and standardization ... only 25 ml, and became clinically relevant at volumes of 75 ml, when diagnosing IAH at a threshold of 12 mmHg [8]. This potential misdiagnosis was actually common...

Ngày tải lên: 13/08/2014, 01:20

... determination of intra-abdominal pressure (IAP) [5]. Despite the simplicity of this method, it remains poorly standardized across the published literature. Basic research into the validity and standardization ... only 25 ml, and became clinically relevant at volumes of 75 ml, when diagnosing IAH at a threshold of 12 mmHg [8]. This potential misdiagnosis was actually common...

Ngày tải lên: 13/08/2014, 01:20