Báo cáo y học: "Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway" pot

... whether resistance of infected cells to apoptotic stimuli involves modulation of active viral replication. In the present study, persistently-infected pro-monocytic and T-cell lines and their uninfected ... U937 and 30% in U1 cells Apoptosis resistance is independent of the magnitude of viral replicationFigure 2 Apoptosis resistance is ind...

Ngày tải lên: 13/08/2014, 06:20

... by mediastinal lymph node T cells. Interestingly, in the same mice, the levels of instructing cytokines were severely impaired. Interestingly, inhalation of a TLR4 antagonist to target ECs suppressed the ... within the lungs of acute inflammatory cells and the local production of proinflammatory mediators [66]. This may be caused by ventilator-induced activation of...

Ngày tải lên: 12/08/2014, 14:20

... inferring prognosis from gene profiling is the major task. Overall, the present study was not designed primarily to increase our understanding of RA physiopathology but is mostly suited to the ... profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and tumour necrosis factor. Inflamm Res 2005, 54:10-16. 42. Zhou A...

Ngày tải lên: 09/08/2014, 08:22

... assessment of depressive symptomatology. The main finding of our study is that early change in pain severity was strongly associated with a long-term reduction of depressive symptoms according to the mean ... analysis of the mean KUSTA score are given in Table 3. In the logistic regr ession analysis of the response rate in the IDS-C total score (50% reduction [...

Ngày tải lên: 11/08/2014, 15:22

... epithelial cells by the Th2 cytokine IL-13 [7,15]. On the o ther hand, Bingle and co-workers found increased SPLUNC1 prot ein in airway epithelium of patients with cystic fibrosis [16]. It remains ... matching algorithm using SpectrumMill. The y- axis indicates the relative intensity of the fragment ions, where 100% is the total ion intensity of the spectrum. (C)...

Ngày tải lên: 12/08/2014, 11:23

... destruction of HIV type 1 (HIV-1) by complement. Presentation of the hypothesis Intrinsic resistance of HIV against the complement system As mentioned above, HIV is resistant to lysis by the com- plement ... the surface of HIV. Testing the hypothesis: Our hypothesis was tested using cell-free HIV-1 virions cultivated in vitro and assessment of virus opsonization...

Ngày tải lên: 12/08/2014, 04:20

... the wards by the multidisciplinary tracheostomy review team. The team consists of an intensivist, an ICU liaison nurse, a physiotherapist, a speech pathologist, and a dietician. Twice- weekly ... to the formation of the team. This limited the nature of data available for comparison and raises the possibility that there were other factors influencing tracheostomy care –...

Ngày tải lên: 13/08/2014, 10:20

... monotherapy (46%), the combina- tion of ZDV and ddI (37%) or other combination therapy (15%). Baseline characteristics of the children in this resistance analysis were very similar to the baseline ... total of 92 children assigned to a RTV-containing regi- men had both baseline resistance information and viral load measurement at week 12, and they were included in...

Ngày tải lên: 10/08/2014, 05:20

... lamivudine resistance. Induction of isoleucine or valine in the YMDD motif results in a sterical hindrance, preventing lamivudine from appropriately configuring into the nucleotide bind- ing site of ... treatment and the genotypic resistance profile emphasize the need for systematic analyses of the HBV resistance mechanisms and structured therapy concept also fo...

Ngày tải lên: 12/08/2014, 04:20

... see things differently than us. They never introduce them- selves as artists, it's apparent that they are. Dave was an artist and actually received some artistic training early in his life. ... (Figure 1) and his nephew Daniel, one challenged by learning disa- bilities and the other by deafness, he gave the precious gift of not lowering his expectations. He showed them agai...

Ngày tải lên: 12/08/2014, 23:22