Báo cáo y học: "Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy" pps

... superna- tants were collected every 3 days for 12 days and supernatants were analyzed using the HIV-1 p24 EIA. Asterisks denote unde- tectable p24 levels. (E) On day 12, YU2 -infected macrophages were analyzed ... is increasingly apparent that many PI3K/Akt inhibitors under development as anti-cancer therapy are safe and well-tolerated in both experimental animals and humans [54-57]. I...

Ngày tải lên: 13/08/2014, 06:20

... inversely related to total plasma antioxidant capacity; as age and weight increased, the total plasma antioxidant capacity decreased. Conclusion: Shift work can act as an oxidative stressor and may ... plasma antioxidant capacity after the night shift was 105.8 µmol/L (SD: 146.39). Also, a significant correlation was shown between age and weight and total plasma antioxidant capacity. Ag...

Ngày tải lên: 10/08/2014, 09:20

... whereas the right epididymal tubules were dilated with motile spermatozoa. Therefore, we performed a right-sided vasovasostomy and ipsilateral epididymovasostomy simultaneously. Disappointingly, ... uropathies: aetiology and management. Fetal Ther 1988, 3:67-83. 6. Pryor JL, Mills SE, Howards SS: Injury to the pre-pubertal vas deferens. I. Histological analysis of pre-pubertal human vas. J Ur...

Ngày tải lên: 10/08/2014, 23:21

... the MELD score, an association between MELD score and HE, as well as HE and mortality, are asserted. HE is an important complication of decompensated liver cirrhosis, and it is associated with ... mg/dl, creatinine 0.7 mg/dl, a lkaline phosphatase 220 U/L, aspartate aminotransferase (AST) 18 U /L, alanine aminotransferase (ALT) 30 U /l, g-glutamyl transpeptidase 20 U/l, total bilirubi...

Ngày tải lên: 11/08/2014, 17:21

... pro- voke an inflammatory response. Eventually the cysticerci calcify and can be seen on X-ray. The organs most com- monly affected by cysticercosis are the eye (13% to 46%), subcutaneous tissue ... and lodge in human tissues in the same way as occurs in pigs. Viable cysticerci do not elicit inflammatory changes in the surrounding tissues. How- ever, when they die they can release substan...

Ngày tải lên: 11/08/2014, 21:22

... evidence of any distant metas- tases. Tongue metastasisFigure 1 Tongue metastasis. CT scan showing primary tumour of left kidneyFigure 2 CT scan showing primary tumour of left kidney. Journal ... retroperitoneum until metastatic disease appears. It can metastasize to any location in the body, and its propensity to metastasize to unusual sites has been well documented. Approximately 30% of pat...

Ngày tải lên: 11/08/2014, 21:22

... gradi- ents, as previously described [56]. Monocyte viability and purity of cells was routinely > 90%. For in vivo studies, monocytes were fluorescently dye-tagged with PKH26 by using a dye kit per manufacturer's ... temperature), monocytes were collected from the top layer of solution (5 mm). Monocytes were > 95% pure, and viability was >98% by trypan blue exclusion. In vitro...

Ngày tải lên: 12/08/2014, 14:22

... Fibβ, rabbit anti-human Fibγ and rab- bit anti-human fibronectin. Anti-rabbit HRP labelled antibody was used as a secondary antibody. ECL detec- tion was carried out by means of Supersignal West Dura Extended ... for RA and has a sensitivity of 78.6% and a specificity of 80.8% [13]. The RF factor is also found in other diseases such as sys- temic sclerosis (20 to 30%) [14] and occasionall...

Ngày tải lên: 12/08/2014, 14:22

... cardiology and oncology. This study has several strengths. It formally addresses the important issue of what might be an appropriate duration of follow-up for the assessment of mortality as an outcome. ... interpret. Measurement of mortality at 28-days or censoring at hospital discharge have logistic advantages but as many as one-third of critically ill patients may still be in hosp...

Ngày tải lên: 13/08/2014, 18:22

... using an anti-CD52 antibody (1:100 GeneTex, Inc) and anti-VE-Cadherin FITC antibody (1:200 Bender MedSystems). Immunohistochemistry was performed on murine tumors with anti-CD31 antibody (1:800 ... that myeloid cells such as vascular leukocytes (VLC) and Tie2 + monocytes play a critical role in tumor angiogenesis and vasculogenesis. Myeloid cells are a primary cause of resistance to anti-...

Ngày tải lên: 18/06/2014, 15:20