... of cases by the presence of antinuclear antibodies[1]. SSc may affect virtually any organ of the body, includ-ing skin, gastrointestinal tract, lungs, heart, kidneys, and musculoskeletal system. ... Our findingsdemonstrate the occurrence of selective alterations in A2B ARdensity and signalling in SSc.Keywords: adenosine, A2 adenosine receptors, neutrophils, receptor binding, systemic ... adenosine deaminase; AR = adenosine receptor; Bmax = maximum number of binding sites; CGS21680 = (2-p-[2-car-bowyethyl]pheylethylamino)-5'N-ethylcarboxamidoadenosine; CPA = cyclopentyladenosine;...