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Báo cáo y học: " Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses" ppt

Báo cáo y học:

Báo cáo y học: " Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses" ppt

... CentralPage 1 of 11(page number not for citation purposes)RetrovirologyOpen AccessResearch Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic ... containing syncytia in response to focal areas of virus infected cells. Plates were fixed and stained 3 dayslater and examined for plaques of syncytia. Syncytium formation and inhibitors of N-linked ... cyto-pathic and/ or infectious in the transfectants.Effect of glycosylation inhibitors on cellular proteins involved in virus entryThe glycosylation inhibitor tunicamycin (Tu) was previ-ously shown...
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Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf

... severity of arthri-tis was scored by grading each paw from 0 to 4 based onerythema, swelling and deformity of the joints, resulting in a maximum score of 16.MHC class II–peptide binding assayLewis ... start of each experiment. This studywas approved by the Dutch Committee of AnimalExperiments. Induction and clinical evaluation of AAAA was induced by intradermal injection at the base of thetail ... administration wasrepeated four times with an interval of 3–4 days.Delayed-type hypersensitivity assayPeptides were dissolved in PBS (2 mg/ml) and 50 µl wasinjected in one ear. PBS was injected...
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Báo cáo y học: "A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis" ppt

... of cases by the presence of antinuclear antibodies[1]. SSc may affect virtually any organ of the body, includ-ing skin, gastrointestinal tract, lungs, heart, kidneys, and musculoskeletal system. ... Our findingsdemonstrate the occurrence of selective alterations in A2B ARdensity and signalling in SSc.Keywords: adenosine, A2 adenosine receptors, neutrophils, receptor binding, systemic ... adenosine deaminase; AR = adenosine receptor; Bmax = maximum number of binding sites; CGS21680 = (2-p-[2-car-bowyethyl]pheylethylamino)-5'N-ethylcarboxamidoadenosine; CPA = cyclopentyladenosine;...
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Báo cáo y học: "Vitamin D receptor gene BsmI polymorphisms in Thai patients with systemic lupus erythematosus" potx

... examine the characteristics of VDR geneBsmI polymorphisms in patients with SLE and the relationship of polymorphisms to the susceptibility and clinicalmanifestations of SLE, VDR genotypings of ... betweenVDR polymorphism and many non-skeletal diseases [20].Although SLE has features consistent with Th2-type cytokinepredominance, both Th1 and Th2 cytokine may be involved in the pathogenesis of ... between the disease and alleles of immunologically relevant genes, including certain major his-tocompatibility complex (MHC) loci, Fcγ receptor, and cytokines [1]. 1,25-dihydroxyvitamin D3 is thought...
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Báo cáo y học: " A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab" docx

... physiological association between osteocal-cin and bone formation. The findings suggest a defect in boneformation that may be explained, in part, by systemic inflamma-tion. Indeed, in one of ... were included in several analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables and ... was not yetavailable. Lumbar and femoral neck BMD was measured usingdual energy X-ray absorptiometry at baseline and 1 year later.Osteocalcin, C-terminal cross-linked telopeptide of type Icollagen,...
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Báo cáo y học: " Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report" pdf

... pulmonary infections are still a dan-gerous consequence of the secondary humoral immunedeficiency in CLL, the frequency and severity of the infec-tions in our patient were certainly due to a combinedhumoral ... detectablehemolysis. In addition, protracted thrombocytopeniaImmunophenotype of chronic lymphocytic leukemia of the B-cell-lineage at primary diagnosis in 2002: 61.7% of gated lym-phocytes show CD20 ... Corresponding author AbstractIntroduction: Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly basedupon clinical staging because of the heterogeneous clinical course of this...
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Báo cáo y học: " Fluorodeoxyglucose-positron emission tomography/computed tomography in the staging and evaluation of treatment response in a patient with Castleman''''s disease: a case report" pps

... have no competing inter-ests.Authors' contributionsEP is the senior author and was involved in collectingpatient details, reviewing the literature and final proof-reading of the manuscript. ... Turin, Italy and 2Nuclear Medicine Unit, University of Turin, Corso Bramante, 10126 Turin, ItalyEmail: Ettore Pelosi* - e.pelosi@irmet.com; Andrea Skanjeti - askanjeti@yahoo.it; Angelina ... details, reviewing the literature and drafting themanuscript. AC was involved in reviewing the literature and proofreading the manuscript. VA approved the finalmanuscript.ConsentWritten informed...
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Báo cáo y học: " Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma" doc

... pathophysiology. CRA chal-lenge similarly resulted in induction of lung cytokines and chemokines. These included the TH2 cytokines IL-4 (P <0.05) and IL-5 (P < 0.05), whose actions include, ... RM, Warmington K, Lincoln P, Chensue SW,Kunkel SL: Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chem-okines in allergic airway inflammation. ... hormone receptor agonist (P < 0.05).PIO reduces pulmonary cytokine and chemokine levels as effectively as DEXOverproduction of a variety of cytokines and chemokinesis characteristic of asthma...
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Báo cáo y học: "Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease" pps

... purposes)acute inflammatory reaction involving numerous neutrophils.Inflammatory infiltrates were observed within the proliferating and thickened synovial lining layer with profound lymphocytic and granulocyte ... disease Skin, joints, keratinocytesKnockout, conditional knockout and gain of function (transgenic) approaches applied to study the role of Jun and Fos proteins during development and in diseases. ... bed and spreadproximally with time, finally leading to onychodystrophy [51].The relationship between skin and nail involvement and jointmanifestations is not resolved [51]. A detailed analysis...
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Báo cáo y học: "Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise" pdf

... c-Jun-N-terminal kinase induced by IL-1β [17].  is resulted in the reduced accumulation of phosphorylated c-Jun and activation protein-1 DNA binding activity, and of activation protein-1-mediated in ... by the activation of synovial tissue lining the joint capsule, which results in the invasion of the cartilage and bone leading to the progressive joint dysfunction [1]. Severe morbidity and ... by inhibiting RANKL-induced activation of c-Jun-N-terminal kinase and NF-κB pathways, thereby suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors [36].Regulation of...
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