Báo cáo y học: "Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export" pps

... DNAH7- 201 18661 196431742 C G S 2590 V L Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (HDHC2) Recurrence 4 ENSG00000156234 ... establish- ment of repositories containing the genomic and tran- scriptomic information of individual cancers coupled with their clinical responses to therapeut ic inter...

Ngày tải lên: 09/08/2014, 20:22

... ubiquitinated in response to DNA damage Since Tax is ubiquitinated in response to DNA damage (Figure 2) and its subsequent translocation to the cyto- plasm following UV irradiation depends on lysine ... that DNA damage results in increased mono-ubiquitination of Tax. Mutation of Tax amino acids known to be targets of ubiquitination (K280 and K284)...

Ngày tải lên: 13/08/2014, 06:20

... a robust analysis of the bronchodilatory dose response to indacaterol. This involved pooled analysis of study-level data to characterize the bronchodilatory dose response, and nonlinear mixed-effects ... provide sustained bronchodilation that is largely independent of disease severity. Finally, it is instructive to place the findings of this analysis in the context of t...

Ngày tải lên: 12/08/2014, 13:22

... evaluating the pathogenesis of chronic aspira- tion-associated disease. In the current study, histology Cytokine response to chronic aspiration of gastric fluidFigure 7 Cytokine response to chronic ... aspirations, assisted with anal- ysis of cytokine levels, and histology data, and helped to prepare the manuscript. SML helped with analysis of cytokine data and assis...

Ngày tải lên: 12/08/2014, 15:21

... to the reaeration of previously collapsed lung units [9]. However, this hypothesis may be invalidated by the heterogeneity and complexity of the reaeration process after an increase in airway ... manually delineated on the ZEEP CT section was manually delineated on the two corresponding CT sections obtained in PEEP con- ditions. In each of the two regions of interest delinea...

Ngày tải lên: 12/08/2014, 23:24

... in keeping with a previous study that also reported an early expression of genes involved in protein synthesis in a salt-tolerant rice variety in response to salt stress [8]. Genes involved in ... expression profiling is an alternate way to identify pathways and genes regulating the stress response [2]. Plants induce expression of a number of genes in response t...

Ngày tải lên: 12/08/2014, 03:21

... in the Toll and imd pathways, and some of the serine-type endopeptidases. However, the signaling in the Toll and imd pathways in response to parasi- toid attack was atypical compared to the antimicrobial response, ... signaling pathway factors Phosphotidylinositol 3-kinase (PI3K) - GTP-binding proteins (Ras/Rho family members) - Protein kinase C (PKCs) or PKC regulators C...

Ngày tải lên: 14/08/2014, 15:20

... neuroendocrine cells. Tyrosine hydroxylase (TH, EC 1.14.16.2) catalyzes the conversion of L -tyrosine to L -dihydroxyphenylalanine ( L -DOPA), the rate-limiting step in the biosynthesis of dopamine and ... protea- somal inhibitor clasto-lactacystin b-lactone was used in the present study. The inhibitor is a lactacystin analog with a potency of  10 times that of lactacystin a...

Ngày tải lên: 17/03/2014, 17:20

... clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistanc...

Ngày tải lên: 25/10/2012, 11:48

... contributing to the efficacy of combination LAM and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary ... After one year, reinfection occurred in 20% of patients in each group, but the finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 recei...

Ngày tải lên: 02/11/2012, 11:17