Báo cáo y học: "Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection" ppt

... purposes) Retrovirology Open Access Research Role of the long cytoplasmic domain of the SIV Env glycoprotein in early and late stages of infection Andrei N Vzorov* 1 , Armin Weidmann 1,4 , Natalia L Kozyr 2 , ... and the fusion activity of the Env glycoprotein [10,11]. SIV and HIV Env glycoproteins contain a relatively long cytoplasmic do...

Ngày tải lên: 13/08/2014, 05:22

... mortality in 3 months (including Fishman’s study); B: mortality in 6 months; C: mortality in 12 months(including Fishman’s study); D mortality in 3 months (excluding Fishman’s study); E mortality ... but the efficacy should be assessed immediately. Herein, we performed a meta-analysis of RCTs published in the past 11 years for the sake of evaluating safety, short-term...

Ngày tải lên: 10/08/2014, 09:22

... mono- therapy alone did not significantly affect any of the levels of these circulating chemokines and cytokines. Discussion Treatment with L-4F, in the absence or presence of pravastatin, effectively ... fast- protein liquid chromatography; HDL: high density lipoproteins; H & E: hema- toxylin and eosin; HMG-CoA: 3-hydroxy-3-methylglutaryl-coenzyme A; IL: inter- leukin; i....

Ngày tải lên: 12/08/2014, 12:20

... [17]. The enzyme structure of FIV IN is similar to that of HIV-1 IN; and it is organized in C- and N- terminal domains, and a catalytic core domain (CCD). The C-terminal domain is likely to be involved ... analysis was intended to analyze the similarities of the CCDs of the mature lentiviral proteins, rather than to reconstruct a phylogeny of the Lentiviru...

Ngày tải lên: 13/08/2014, 05:22

... at the time of chloroplast origin had poorly defined interactions between Cyt f and plastocyanin and/ or plasto- cyanin and photosystem I, and subsequently the nature of the interactions in the ... mutated negatively and positively charged residues on the proposed interaction site of plastocyanin with cytochrome f and analysed the reaction of these mutants with...

Ngày tải lên: 21/02/2014, 01:21

... modifications of SQDG impaired the recovery of PSII activity. The results suggest that SQDG is indispensable for PSII activity in Chlamydomonas by main- taining PSII complexes in their proper state. Keywords: ... sulfoquinovosyl diacylglycerol; photosystem II; Chlamydomonas; thylakoid membrane; glycolipid. The primary process in photosynthesis occurs in thylakoid membranes. P...

Ngày tải lên: 22/02/2014, 04:20

... from the hydroxyl side chain of tyrosine 229. This displacement may be facilitated involving by R389 through lowering the pK of the tyrosine hydroxyl group. The proton is delivered to the carboxybiotin ... serine hydroxyl and an aspartic acid, these experiments argue strongly against an acidic function of the serine hydroxyl; (d) upon replacing serine by alanine the enzy...

Ngày tải lên: 08/03/2014, 23:20

... measured by the dye equilibration method of Minnaert [17], in order to assess changes in the thermodynamic properties of the flavin centre caused by the mutation and to explain the different thermodynamic ... to Y2 24 of the mammalian enzyme (the residue interacting with the a-amino group of the substrate and with a buried water molecule). Y2 24 in pkDAAO...

Ngày tải lên: 17/03/2014, 17:20

... in uen- tial in defining the stability of Compound II. The replacement of the distal histidine residue by alanine or glutamic acid clearly has a profound in uence on the ability of the rAPX enzyme to ... hydrogen-bond- ing structure involving the N e of His42 and the ferryl oxygen. However, although hydrogen-bonding interactions of this kind have been structurally...

Ngày tải lên: 18/03/2014, 01:20

... or by targeting enzymes involved in leukotriene biosynthesis. Zileuton is a 5-lipoxygenase inhibitor that inhibits the formation of LTA 4 from arachidonic acid, thereby preventing cysteinyl leukotriene ... than that of his- tamine or methacholine, which indicates that these mediators are extremely potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cystei...

Ngày tải lên: 08/08/2014, 20:23