Báo cáo y học: " Bridging fundamental RNA biology, retroviral replication, and oncogenesis: Karen Beemon wins the 2007 " pps

... viral RNA behaved differ- ently than predicted by those studying cellular mRNAs. Many of the important discoveries in RNA biology were made by study of viral RNA. The only disadvantage is you have ... scientist and a mother. References 1. Jeang KT: Life after 45 and before 60: the Retrovirology Prize. Retrovirology 2005, 2:26. 2. Jeang KT: The young, not-so-young, and the...

Ngày tải lên: 13/08/2014, 05:22

... endothelial cells, the hemangioblasts, the MAPCs and the myelo/ monocytic cells. Two groups of EPCs have been defined in in vitro models, the early EPCs, which are derived from the monocytes and ... pathways. This review provides a comprehensive up-to-date understanding of the physiological function and therapeutic utility of these cells. The emphasis is on the systemic...

Ngày tải lên: 10/08/2014, 21:23

... Delude 3 Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent ... technology by RNA inter- ference. Specifically, we utilized small interfering RNA (siRNA) t o silence PARP-1 gene and hypothesized that the heat shock response is negatively mod...

Ngày tải lên: 11/08/2014, 03:20

... we employed post- transcriptional gene silencing technology by RNA inter- ference. Specifically, we utilized small interfering RNA (siRNA) t o silence PARP-1 gene and hypothesized that the heat ... factor of the heat shock response by reg- ulating the expression of HSP-70. Both protein-protein interaction and catalytic activity of the PARP protein play a key role in modulation...

Ngày tải lên: 11/08/2014, 06:22

... All groups were treated daily for 7 days. Thereafter, the mice were killed by cervical dislocation and the hind paws were collected and used for further analysis. The in vivo experiments were ... chondrocytes and synovial fibroblasts. Ann Rheum Dis 2004, 63:43-49. 8. Jungo F, Dayer JM, Modoux C, Hyka N, Burger D: IFN-beta inhibits the ability of T lymphocytes to induce TNF-alpha...

Ngày tải lên: 09/08/2014, 01:23

... horoughly and counted using the Wizard 1470 gamma counter (Perkin Elmer/Wallac, Turku, Finland). The sensitivity of the assay was 0.2 μg/ dl. The CV% for the Quality Control samples at low, medium and ... 9:3 http://www.jcircadianrhythms.com/content/9/1/3 Page 8 of 8 realignment of the MT rhythm should instead be viewed as further evidence that in the horse the MT rhythm i...

Ngày tải lên: 10/08/2014, 09:20

... manuscript as the main author. RSUY was involved in reviewing the literature and proof reading of the manuscript. RSUY has approved the final manuscript. SSB is the senior author and was responsible ... a rare and easily missed injury in the presence of major distracting injuries: a case report Ulfin Rethnam*, Rajam SU Yesupalan and Salah S Bastawrous Address: Glan Clwyd H...

Ngày tải lên: 11/08/2014, 10:22

... on the displaced strand of the D-loop allows lagging strand synthesis (panel A). In bubble-migration synthesis, lagging strand synthesis does not occur, and the newly synthesized single strand ... 2B). The net result is that a newly synthesized single-strand copy is created and then quickly extruded from its template, and lagging-strand synthesis does not occur within the D-lo...

Ngày tải lên: 11/08/2014, 21:21

... read the article by Barthel and colleagues [1] in this is sue of Arthritis Research &  erapy with great interest.  ey reported that neurotrophin receptors/ligands and specifi cally nerve ... looked for the cellular source of NGF and demonstrated that the T cells and monocytes/macro- phages derived from SF of patients with RA/SpA are enriched with NGF. Furthermore, they...

Ngày tải lên: 12/08/2014, 14:21

... in the 3'LTR are alternatively spliced and polyadenylated. Retrovirology 2006, 3:15. 10. Cochrane AW, McNally MT, Mouland AJ: The retrovirus RNA trafficking granule: from birth to maturity. ... Sometimes the impact factor outshines the H index. Retrovirology 2008, 5:88. 4. Freed EO, Mouland AJ: The cell biology of HIV-1 and other ret- roviruses. Retrovirology 2006, 3:77....

Ngày tải lên: 13/08/2014, 05:21