Báo cáo y học: "Optimal design and validation of antiviral siRNA for targeting HIV-1" potx

... manuscript. KN and TO performed the viral replication assays. RU analyzed the data. KU-T participated in the target mRNA cleavage assays, and was Validation of 41 siRNAsFigure 2 Validation of 41 siRNAs. ... their antiviral efficacy against three evolutionary-distant groups of HIV-1: sub- types B and B' (Thailand variant of subtype B [16]); sub- type C; and CRF01_AE....

Ngày tải lên: 13/08/2014, 05:22

... Biostatistics and Epidemiology Unit, Faculty of Movement and Sport Science, and Department of Medicine and Public Health, University of L’Aquila. L’Aquila, Italy 2. Supportive Care and Rehabilitation ... Oncology Department, Faculty of Medicine, University of L’Aquila. L’Aquila, Italy 3. Sport Science Unit, Faculty of Movement and Sport Sciences, University of L’...

Ngày tải lên: 08/08/2014, 16:23

... events (in units of thousands of years, kyr) and population sizes are indicated. (b) The site frequency spectrum for sample sizes of 50 and 2,000 chromosomes. (c) Average value of Tajima’s D ... easier to study using exons, as many existing statistical tests for estimating selection, such as those based on the ratios of nonsynonymous to synonymous sites, are appropriat...

Ngày tải lên: 09/08/2014, 23:20

... University of California Santa Cruz. Authors' contributions MS and JMG designed the assays and strategies for its analysis, MS performed all library preparation and characterization, MS, DL and ... properly cited Method Optimized design and data analysis of tag-based cytosine methylation assays Masako Suzuki, Qiang Jing, Daniel Lia, Marién Pascual, Andrew McLellan and...

Ngày tải lên: 09/08/2014, 20:21

... study hypothesis is that systolic and diastolic gradients, a marker of normal left ventricular function, may be related to physiological asynchrony between basal and apical myocardial segments and ... Contributed equally 1 Faculty of Medicine of University of Oporto, Department of Physiology, Alameda Professor Hernâni Monteiro, 4202-451 Porto, Portugal Full list of author in...

Ngày tải lên: 10/08/2014, 09:21

... are typically given low publication priority scores and may not be accepted for publication [2], we hypothesized that the pressure for publication among authors and the fierce competition for ... and lung malig- nancy) SNPs for GST polymorphisms were used as a substrate for analyses. Materials and Methods Search strategy and eligibility criteria We electronically se...

Ngày tải lên: 25/10/2012, 10:51

... prevalence of hyperopia and myopia. As age increased, the prevalence of hyperopia signif- icantly decreased and the prevalence of myopia in - creased. Based on the definitions of hyperopia (≥+2.00 ... prevalence of hyperopia markedly decreased, and that of myopia significantly increased. The prevalence of hyperopia was 48.12% (≥ +1.50 D SE) and 9.21% (≥ +2.00 D SE) a...

Ngày tải lên: 25/10/2012, 11:40

... Golakoti T, Sarma KV, Dey D, Raychaudhuri SP. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin ® for treatment of osteoarthritis of the knee. Arthritis ... clinical trial. Evaluations of physical activity and pain scores, serum biochemistry, hematology, and urine biochemistry were done at baseline (day 0) and on days 7, 30, 60...

Ngày tải lên: 25/10/2012, 11:40

... consideration also for other combinations of phosphatases and interme- diary phosphorylated enzymes. Therefore, kinetic data on the dephosphorylation of autophosphorylated ATP-citrate lyase in the paper ... at the Peptide Synthesis and Analysis Laboratory of the Department of Medical Biochemistry and Microbio- logy, Uppsala University. The SP6 primer 5¢-ATT TAG GTG ACA CTA TAG...

Ngày tải lên: 21/02/2014, 01:21

... ortholog of HRPC2 (91% amino acid identity). Shinmyo et al. [64] have studied the promoter activity and wound-induction of HRPC and -E types, and of AtPCa and AtPEa. Most remarkably, C2, and only C2, responded ... a nonglycosylated triplet at position Asn70 [48]. The majority of the peroxidases carry one or two putative glycans. Seven appear to be nonglycosylated. Therefore,...

Ngày tải lên: 21/02/2014, 01:21