... PC12 cells Mutsuya Yamamoto, Takeshi Hioki, Takehisa Ishii, Sadayo Nakajima-Iijima and Shigeo Uchino* Pharmaceuticals Discovery Laboratory, Yokohama Research Center, Mitsubishi-Tokyo Pharmaceuticals ... and physiological or pathological neuronal cell death. However, it is not known whether DAP kinase activity is critical for neuronal cell death. Ceramide, generated by sphingomyelin hydr...
Ngày tải lên: 24/03/2014, 00:21
... arthritis model, and performed the ELISAs and apoptosis assays. JH performed all flow cytometry work. EB assisted with all measurements for arthritis. GKH was the pathologist who analyzed the tissue ... Joy Eslick for her assistance with flow cytometry (Saint Louis University Flow Cytometry Core Facility). References 1. Catrina AI, Trollmo C, af Klint E, Engstrom M, Lampa J, Hermans- s...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Multislice computed tomography is useful for evaluating partial anomalous pulmonary venous connectio" pdf
... angiography clearly reveal the morphology of pulmonary venous con- nection without any need for mental reconstruction, facilitating precise planning of the operation. MDCT angiography is useful for ... (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Commentary Mult...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
... presence of any form of cancer, liver disease, primary renal disease or any collagenic diseases. All subjects gave informed consent before the study began. Patients who had history of myocardial ... tHcy has a positive effect on the hydroxyl methyl glutaryl -CoA synthase enzyme ( the rate limiting enzyme in cholesterol biosynthesis) and hence hypercholesterolaemia. Furthermore, they sugg...
Ngày tải lên: 03/11/2012, 09:49
Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot
... llular polyamines c omes from t heir synthesis from amino acid precursors. In this biosynthesis pathway ornithine is decarboxylated to form putrescine by the action of ornithine decarboxylase (ODC, ... ubiquitin system for its degradation. DISCUSSION Antizyme is a unique cellular regulatory protein that is both regulated by polyamines and regulates polyamine metabo- lism in a feedback...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc
... guanyly cyclase C by a guanine nucleotide-dependent mechanism. Biochemistry 35, 3213–3221. 27. Desaubry, L., Shoshani, I. & Johnson, R.A. (1996) Inhibition of adenylyl cyclase by a family of ... frozen-thawed once only for analyses. Guanylate cyclase activity Guanylate cyclase activity was quantified as described previously [24]. Brie y, 20 lg of supernatant or membrane protein were incu...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf
... [15]. RESULTS P70 ik3-1 is phosphorylated by cyclin A/cdk2, cyclin E/cdk2, cyclin A/cdk3 or cyclin E/cdk3 which is produced in the baculoviral system We initially tested a hypothesis that p70 ik3-1 might ... resembles the site in p53 which is phosphorylated by cyclin A/cdk2 [16]. We therefore asked whether this position is the phosphorylated Fig. 3. p70 ik3-1 is phosphorylated by cy...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo y học: "Advanced paternal age is a risk factor for schizophrenia in Iranians" pps
... respectively). Logistic regressi on analy- sis (Table 4), adjusting for the effect of maternal age, birth rank and family history, indicated that paternal age is an independent predisposing factor ... a nutrient required for the biosynthesis of TTP and DNA synthesis as well as purine nucl eotides that are necessary for DNA and RNA synthe sis and other cellular processes (for example...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "Collagen-induced arthritis is exacerbated in IL-10-deficient mice" pps
... arthritis synovial fluid, these findings may have relevance to rheumatoid arthritis. Keywords: antibody, arthritis, autoimmunity, cytokines Open Access Although CIA is considered a Th1-type disease ... autoreactive T cells activate B cells by two distinct pathways. J Immunol 1984, 133:78. 29. Mikecz K, Glant TT, Buzas E, Poole AR: Proteoglycan-induced polyarthritis and spondylitis adoptivel...
Ngày tải lên: 09/08/2014, 01:21