Báo cáo y học: " The HIV RNA setpoint theory revisited" pps

... infec- tion. For the evolution of viral load, the setpoint theory was introduced soon after the implementation of HIV RNA assays [1,2]. Three components describe the setpoint behaviour after the high ... time depend on the scale that is used to visualize trends. In reconsidering the setpoint theory for HIV RNA, we analyzed the evolution of CD4 T-cell count and...

Ngày tải lên: 13/08/2014, 05:22

... making the HIV- 1 RNA more amenable to RNA- RNA and RNA- protein interactions in the cytopla sm, which support subsequent RNA encapsidation. Nonetheless, the com- bined effects of the Rev/RRE system ... [20]. Furthermore, the tRNA Lys primers may also promote reverse transcription at a low efficiency from the MLV PBS (normally primed by tRNA Pro ) in the heterologous MLV...

Ngày tải lên: 13/08/2014, 01:21

... as the metabolic machineries for RNA in the cytoplasm are made by RNA- binding proteins, some of which mark the RNA before their exit from the nucleus and modulate RNA fate in the cytoplasm. The ... of the unspliced 9 kb and singly spliced 4 kb viral RNAs in the nucleus [93-96]. Only the fully processed 2 kb viral mRNAs accumulate in the cytoplasm in the absence...

Ngày tải lên: 13/08/2014, 09:21

... is that involved in the dimer linkage of HIV- 1. The discovery of the sequences involved, the subsequent description of the RNA: RNA interaction, and the elucidation of the terti- ary interaction are ... affect the auto-complementarity of the sequence. One of the key differences between HIV- 1 and HIV- 2 rep- lication is their modes of packaging [32]. Whilst the Gag...

Ngày tải lên: 13/08/2014, 13:20

... a variety of hydrolytic enzymes into the cytosol. Such lysosomal enzymes may directly activate Bid, pro-caspases, or lytic cytosolic pro-enzymes such as phospholipase A2, while the latter, together ... ferryl or perferryl radicals) may be sufficient to jeopardize the stability of the lysosomal membrane and to induce leak into the cytosol of lysosomal lytic enzymes. Moderate release o...

Ngày tải lên: 17/03/2014, 23:20

... eccentrically starting from the junction zone, where the bone, the cartilage and the synovial membrane are closely attached to each other (Fig. 2). Bone is invaded by an inflammatory synovial tissue, known ... mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration 7 days 35 days 5 days Effect on inflammation No No No Effect on cartilag...

Ngày tải lên: 09/08/2014, 01:23

... survivor values of cardiac index. Oxygen delivery and oxygen consumption as resuscitation endpoints in severe trauma. Trauma 1995, 38:780-787. 5. : Pulmonary Artery Catheter Consensus Conference: consensus statement. ... randomised controlled trial of the effect of deliberate preoperative increase of oxygen delivery on mortality and morbidity in high-risk surgical patients. JAMA 1993, 270:2...

Ngày tải lên: 12/08/2014, 18:20

... emphysema. These studies introduce the concept that cells other then inflammatory cells may participate in the destruction of the lung in emphysema. Conclusion Our scope of understanding of the ... from type I and III collagen are widely distributed in the lung. They are present in the adventitia of pulmonary arteries, the interstitium of the bronchial tree, the interlobular...

Ngày tải lên: 12/08/2014, 18:20

... components. Lymphocytes T lymphocyte proliferation and cytokine release is an important step in the further activation of the adaptive immune system in asthma. This T-cell response can induce B lymphocyte ... synthesize lamellar bodies or DPPC. To conclude, local synthesis of surfactant components in the airways might indicate the possibility of adaptation and regulation of the airw...

Ngày tải lên: 12/08/2014, 18:20

... Unfortunately, the authors provide no information on liver function, because most nucleosomal DNA is efficiently cleared by the liver and only a small fraction is eliminated by the kidney [8,9]. ... from further degradation by endonucleases [7]. In healthy individuals, the concentration of circulating DNA is low, because dead cells are removed efficiently from circulation by phagocyte...

Ngày tải lên: 12/08/2014, 23:23