Báo cáo y học: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells" docx

... implicated in the induction of Tregs in murine cells, we set out to investigate whether TGF-β has a role in the unexpected induction of Tregs by TCR stimulation in human T cells. In the human immune system, ... of latent TGF-β by reactive oxygen species generated from the activated T cells. Biologically active TGF-β then engages in the induction of...

Ngày tải lên: 13/08/2014, 05:22

... respond to methotrexate therapy. Introduction Low-dose weekly methotrexate has become the mainstay treatment of rheumatoid arthritis and psoriasis, and it is the gold standard by which other systemic ... IL-10, and IL-12 [23,25-27,47]. In addition to the regulatory effect of adenosine in cytokine secretion, we have further established that Th1 proinflammatory cytokine IL-1...

Ngày tải lên: 09/08/2014, 07:20

... pulmonary surfactant (PPS) in the nebuliser is converted to an aerosol by the jetting power of oxygen. (b) An anesthetised rat is placed in the plastic container and allowed to inhale the PPS ... sur- factant may not only prevent the lung from oedema by stabilis- ing the fluid system in the lung, but may also inhibit the inflammatory response [28]. In this study, we s...

Ngày tải lên: 13/08/2014, 15:22

... the FcγRs. Introduction Rheumatoid arthritis (RA) is a heterogeneous autoimmune dis- ease that is characterized by chronic inflammatory polyarthritis [1]. One of the characteristic features of RA is the ... susceptibility to rheumatoid arthritis. Arthritis Rheum 2000, 43:735-739. 16. Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recogniti...

Ngày tải lên: 09/08/2014, 07:20

... analysis showed that it affects the binding of LYP to Csk, leading to a lack of down- regulation of T- cell activation, which is consistent with an increased susceptibility to autoimmunity for the ... respectively, 5'-GATAATGTTGCT- TCAACGGAATTT-3' and 5'-CCATCCCACACTTTATTT- TATACT-3'. The PTPN22-1858C /T transition at codon 620 eliminates a restriction site fo...

Ngày tải lên: 09/08/2014, 07:20

... underestimate since we measured this only in subjects in whom ART was initiated. This group of subjects will be at increased risk of progressing to disease and transmitting the virus [10,11] and testing ... findings suggesting significant risk to patients with CD4 counts above 200 × 10 6 /l [12]. Our study highlights the urgent need for greater CD4 count testing prior to the ini...

Ngày tải lên: 10/08/2014, 05:21

... addressed in acute pathogen- esis, with particular attention t o innate immunity. Further, we identified the intestinal mucosa as a very sensitive indicator of retroviral infection that is indepen- dent ... Collectively, these findings suggest that mucosal lymphocy tes are the most sensitive indicator of infection as they are dis- rupted regardless of initial viral dose and seroconver...

Ngày tải lên: 12/08/2014, 23:22

... collectors were trained by the principal investigator prior to the data collection period. The data collection tools include: Clinical Specialist outreach visit details sheet, Clinical specialist ... results of this study showed that a total of 23 clini- cal specialist outreach visits were made in 21 visits to the four hospitals. During these visits a total of 139 specialist days (cal...

Ngày tải lên: 13/08/2014, 11:22

... primary trial heterogene- ity by a subgroup meta-analysis of studies that restricted inclusion to only ARDS. This meta-analysis shows that prone ventilation significantly reduces ICU mortality in ARDS ... significant reduction in mortality in the studies that restricted inclusion to only patients with ARDS, and not in those also enrolling patients with less disease s everity....

Ngày tải lên: 14/08/2014, 07:21

... the TGF receptors I and II which may be prevented by interaction of the cytokine with the pseudoreceptor [12]. This mechanism may influ- ence TGF signalling besides other known activation and signalling ... of NTHI-mediated induction of proinflammatory cytokines and inhibition of TGF-β expression may influence inflammation induced tissue remodeling. Introduction Pulmonary prese...

Ngày tải lên: 12/08/2014, 11:22