Báo cáo y học: "Nuclear Factor 90(NF90) targeted to TAR RNA inhibits transcriptional activation of HIV-1" potx

... formed Competition Analysis of RNA Binding SpecificityFigure 1 Competition Analysis of RNA Binding Specificity. A: The structure of the wild type TAR RNA and the TAR mutants used in this assay are illustrated. ... site of NF90ctv to TAR RNA using structural mutants of TAR RNA, and competition with unlabeled RNAs. The secondary structures and free ener- gies of...

Ngày tải lên: 13/08/2014, 05:22

... with dsRNA-dinding motif, while in mitosis NF90 is phosphorylated and translocated to the cytoplasm, without loss of its affinity for dsRNA [23]. It has been reported that NF90 in the cytoplasm ... facilitate export of incompletely spliced and unspliced viral transcripts to the cytoplasm, a necessary step in virus life cycle. The Rev-mediated nucleo-cytoplasmic transport of nascent...

Ngày tải lên: 13/08/2014, 09:20

... the regulation of WD promoter activity. Comparison of WD promoter activity in Ku-deficient Xrs-5 cells to the activity in CHO cells To verify that Ku-80 is an essential regulatory factor in WD gene ... transcription factor Sp1 revealed the presence of nuclear factors that bind specifically to MREa. Two MREa-binding proteins of 70 and 82 kDa were purified using avidin–biotin affin...

Ngày tải lên: 17/03/2014, 23:20

... drugs, were allowed only if they were not reported to alter QT interval. Patients with disturbances of cardiac rate and rhythm, his- tory of prolonged QTc, family history of sudden death, QTc interval ... prolongation and pro-arrhythmia by non- anti-arrhythmic drugs: Clinical and regulatory implications Report on a Policy Conference of the European Society of Cardiology. Cardiovas...

Ngày tải lên: 08/08/2014, 21:20

... crops (76.1% of total yield) was for livestock Figure 1 Study area - Gongshan County, NW Yunnan of China (This picture was provided by CBIK and ICRAF). Shen et al. Journal of Ethnobiology and Ethnomedicine ... county roughly from north to south. With an elevation from 1,170 m to 5,128 m, the typical climate is characterized by both raining season of heavy rainfall with 90% humi di...

Ngày tải lên: 10/08/2014, 09:21

... relevant to fibroblasts and lymphocytes activation, were evaluated by means of flow cytometry and RT-PCR. Proliferative responses of T lymphocytes to concanavalin A were evaluated by the MTT assay. Results: ... typical proinflammatory cytokine [28], was significantly inhibited by fibroblasts, whereas IL-10, com- monly considered as a regulatory cytokine [29] was not affected by fibro...

Ngày tải lên: 12/08/2014, 18:22

... serve to emphasize the potential role of poor dental hygiene in the pathogenesis of VAP. Poor dental hygiene was apparent in 90% of the patients at the time of enrollment into the study. Of the ... developed respiratory infection. These findings add to the growing body of evidence implicating poor oral hygiene as an important risk factor in the development of VAP in...

Ngày tải lên: 13/08/2014, 01:20

... observed in many aspects of a biological system, ranging from loss of cell-cycle synchronization in an initially synchronized population of cells to different hair color of genetically identical ... that the mean transcriptional variation of X-linked genes is no dif- ferent to that of autosomal genes in any of the cell lines ana- lyzed (mean CV of X = 0.149 ± 0.120; mean...

Ngày tải lên: 14/08/2014, 21:20

... Nuclear Factor I (NFI) family of transcrip- tion factors. The NFI family of transcription factors is essential for the development of multiple organ systems including brain, lung, muscle, hematopoietic ... A tool for annotation and analysis of control regions of genes regulated by Nuclear Factor I transcription factors. Journal of Clinical Bioinformatics 2011 1:4. Submit your...

Ngày tải lên: 10/08/2014, 09:22

... TF, tissue factor; TFPI, tissue factor pathway inhibitor; I, inhibitor; VII, factor VII; VIIa, factor VIIa; VIIa–TF, the complex of factor VIIa and tissue factor; E, enzyme; X, factor X; S, substrate; Xa, ... Hemker, H.C. & Lindhout, T. (1999) Inhibition of tissue -factor- factor VIIa-cata- lysed factor X activation by factor Xa-tissue factor pathway inhibitor. J....

Ngày tải lên: 22/02/2014, 04:20