Báo cáo y học: " Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lymphomonocyte sub-populations" docx

... clone containing the region of interest was sequenced in parallel by ultra-deep pyrosequencing and by the Sanger method. The plasmid clone was obtained from a patient's sample by inserting a ... HIV- 1 quasispecies archived in monocytes and T lymphocytes with that present in circulating virions replicating in the same cell types after one month from therapy inte...

Ngày tải lên: 13/08/2014, 05:21

... replacement therapy in the intensive care unit: results from The Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Study Nattachai Srisawat 1 , Loredo Lawsin 1,2 , Shigehiko Uchino 3 , ... Supportive Therapy for the Kidney (B.E.S.T. Kidney) Investigators Writing Committee: Patient and kidney survival by dialysis modality in critically ill patients with acute k...

Ngày tải lên: 13/08/2014, 20:21

... probe marked in millimiter increments. Bleeding on probing was recorded and the presence of plaque was registred mesially, buccally, distally, and lingually. Data were obtained at baseline before ... coadjuvant in the grafting processes to produce bone-like tissue in the presence of employing autologous bone obtained from intra-oral sites, to treat infra-bone defects witho...

Ngày tải lên: 03/11/2012, 11:35

... [14]. In vertebrates the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢- linked oligoadenylates, ... protection against invading microorganisms is the (2¢)5¢)oligoadenylate synthetase [(2–5)A synthetase] system [11–13]. The (2–5)A synthetase(s) is activated by certain clas...

Ngày tải lên: 21/02/2014, 15:20

... AroQ a CMs. The alignment begins with amino acid 13 in 90-MtCM (the numbering begins with amino acid 1 in the 90 amino acid protein). Amino acids 1–12 were not seen in the electron density map; their ... a dimer. In this article, we also report on the cloning of the gene encoding the secreted CM from Yersinia pestis (*YpCM, y2 828), purification of the protein, invest...

Ngày tải lên: 17/03/2014, 17:20

... despite there being no evidence of greater disease activity in terms of clinical scores (skin or joint) or inflammatory markers. Interestingly, the MRI bone oedema score was also higher in the AM ... erosions in PsA (the zoledronic acid in psoriatic arthritis or ZAPA study), but results presented here pertain only to baseline findings in these patients, before administration of...

Ngày tải lên: 09/08/2014, 01:22

... This is inline with the assumption that plasma and memory B cells accumu- late in the parotid gland but cannot clarify the origin of these cells. Whatever the primary aberration in the induc- tion ... generating germinal center-like structures in the salivary glands. References 1. Harley JB: Sjögren’s syndrome. In Systemic Autoimmunity. Bigazzi PE, Reichlin M, eds. New Yor...

Ngày tải lên: 09/08/2014, 03:24

... activity owing to its induction of AP [9]. Figure 2 Hematoxylin-eosin staining (a) and indirect immunofluorescence for collagen types I (b) and II (c) in comparable areasHematoxylin-eosin staining ... ele- ments in the supporting reticular tissue of the bursa and the supraspinatus tendon fibers reaching into the basal portion of the organ, in addition to the dense connective...

Ngày tải lên: 09/08/2014, 08:22

... endothe- lial injury (thrombomodulin) and interstitial lung injury (KL-6), suggesting that elevation of serum HGF counteracts the endothelial and interstitial lung injury caused by SSc [24]. The serum ... were obtained from the Shizuoka Laboratory Animal Center (Hamamatsu, Shizuoka, Japan). All mice were maintained in a pathogen-free facility at the Hyogo College of Medicine (Nish...

Ngày tải lên: 09/08/2014, 08:22

... cellular hypertro- phy, bone core). The evaluation of the synovial layer refers to the additive score by Krenn and colleagues [21], including thickening of the syn- ovial cell lining (grade 0 = single ... HIF-degrading prolyl-hydroxylase have not so far been established. DMOG not only inhibits the HIF prolyl- hydroxylase, but also interferes with collagen prolyl-hydroxy- lases [33]....

Ngày tải lên: 09/08/2014, 13:22