Báo cáo y học: " MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes" ppsx

... It is not clear whether other cellular proteins are important in the steps leading to the initial viral recognition step. Down- stream of this TRIM5α-target interaction, it is expected that cellular ... domain [27,28]. CypA-CA interaction and TRIM- Cyp-mediated restriction are abrogated in the presence of cyclosporine (CsA), a drug that targets the same structural motif in Cyp...

Ngày tải lên: 13/08/2014, 05:22

... titers and mortality but the CTLs were directed to a single NP epitope and were probably inadequate to protect against a lethal influenza challenge. The role of contact-mediated T cell cytotoxicity ... histocom- patibility complex-restricted cytotoxic T lymphocytes are not necessary for heterotypic immunity to influenza. J Infect Dis 1994, 170(5):1195-1200. Respiratory Research 2007...

Ngày tải lên: 12/08/2014, 15:20

... enrolled into the study. Spondyloarthropathy was defined according to the European Spondyloarthropathy Study Group criteria [26]. Out of the spondyloarthropathy- defined patients, 65 patients had ... occurs in inflamed synovial tissue predominantly at sites of attachment and invasion into the cartilage and bone [18]. The TLR2-mediated stimulation of synovial fibroblasts with bacterial c...

Ngày tải lên: 09/08/2014, 07:20

... cells. Note that the sublining stroma in this area is virtually devoid of c19orf10 staining. This pattern of staining is typical of that seen in both RA and OA sections. (d) In most lymphocytic ... was detected in this assay, lending further support to the contention that this pro- tein represents a major component of synovial fluid. At this time, it is unwarranted to try to dra...

Ngày tải lên: 09/08/2014, 10:20

... citation purposes) Active disease is characterized by inflammatory activity. Whilst the effect on CPC numbers and functionality would be inter- esting to study in these patients, this is only temporal ... did not. Competing interests The authors declare that they have no competing interests. Authors' contributions JM was in charge of most of the experimental work, data anal- ysis...

Ngày tải lên: 09/08/2014, 10:20

... without HAART. Clinical, intraoperative and histological findings Table 1 illustrates the clinical and intraoperative features observed in the study population with respect to HIV serostatus. Leukocytosis ... participated in data collection. HDM and JH analysed the data and wrote the first draft of the manuscript. All authors contributed to the manuscript and approved its final...

Ngày tải lên: 10/08/2014, 05:21

... subtypes, including inattentive type, hyperactive-impul- sive type, and combined t ype, according to the predomi- nant clinical manifestations of inattention, hyperactivity, and impulsivity. The validity ... subtypes. There were significant improvements in clinical symptoms of hyperactivity and inattention, and impulsivity performance in CPT during the 6-month treatment. The cli...

Ngày tải lên: 11/08/2014, 15:22

... maintain proximity to attachment figures. That model might explain the pattern of comorbidity , symptom severity and disability displayed by those meeting criteria for ASAD in the pre- sent study. ... “anxiety”. Eligibility for intake is not influenced by either the dura- tion of symptoms or history of prior treatment. At the initial intake assessment, psychologists at the clinic administ...

Ngày tải lên: 11/08/2014, 16:22

... and facilitators to help-seeking. This sys- tematic review seeks to address t his gap. Aims and scope of this study This study is a systematic review of both the qualitative and the quantitative ... the quantitative studies were tabulated and top rated themes extracted. Results 1. Study characteristics The characteristics of each of the qualitative and quanti- tative studies of th...

Ngày tải lên: 11/08/2014, 16:22

... analysis and interpretation of the results. HK supervised the data analysis and contributed to interpretation of the results and editing the manuscript. All authors contributed the interpretation ... physical activity may be protective against depression [50]. Limitations The first limitation of this study is that we used a self- report questionnaire to obtain information about the heal...

Ngày tải lên: 11/08/2014, 16:23