Báo cáo y học: " HIV-1 Nef: at the crossroads" docx

... information database quickly to bear on the management decisions as they are made at the bedside. The value of immediate accessibility to accurate information for education purposes and correct ... or physically debilitated patients may allow earlier intervention or assure compliance with complicated treatment regimens at home, improving the safety and cost- effectiveness of their...

Ngày tải lên: 12/08/2014, 20:20

... severely affected by landmines as a result of the different wars and internal conflicts over the last four decades. Landmines are widely deployed through- out the country especially in the northern ... and sex of patients, type of injury, location of incident and diurnal, monthly and yearly occurrence of injuries were extracted from the case records. The study excluded those injur...

Ngày tải lên: 13/08/2014, 14:20

... crisis: the rapidly aging population. Figure 1 shows what I mean. On these maps I have colored in blue every country in which more than 20% of the population is over 65 years of age. The map on the ... is the world we live in. The map on the right, where virtually every country is blue, is the world our children will live in. In most of the developed world, by 2050 at leas...

Ngày tải lên: 14/08/2014, 21:20

... activity in the fish ovary [47,48]. Given the abovementioned observation that estrogens repress male differentiation it appears that, once initiated, factors of the male pathway downregulate the ... DMRT1 in the sex- determining region of the Y chromosome of the medaka, Oryzias latipes. Proc Natl Acad Sci USA 99, 11778–11783. 9 Matsuda M, Nagahama Y, Shinomiya A, Sato T, Matsu...

Ngày tải lên: 14/02/2014, 19:20

... Nef is attached to the plasma membrane by its myristoyl group and the cytoplasmic tail of CD4. AP-2 binding facilitates the formation of a clathrin coated pit that leads to the internalization ... AP1 has been recently demonstrated separately by the Collins and the Guatelli laboratories [43,45]. This complex appears to activate a cryptic tyrosine sorting signal in the cytoplasm...

Ngày tải lên: 13/08/2014, 05:21

... precipitating factors for the increasing prevalence of atopy in childhood. Previous studies have assessed two related ideas - the hygiene hypothesis and the birth order effect [9]. The hygiene hypothesis ... 0.006), elevated cord serum IgE (p = 0.004) and prematurity (p = 0.008) (Table 3). Similarly, maternal history of atopy, maternal IgE, maternal atopic status and gender were signi...

Ngày tải lên: 08/08/2014, 21:20

... other regulates the release of ER signal sequences from the SRP54 M-domain. Introduction Both secretory and membrane proteins destined for entry into the eukaryotic secretory pathway carry hydrophobic ... was completely depleted of this activity. The specificity of the affinity-purified autoantibodies was further supported by the observation that neither prepara- tion recognized...

Ngày tải lên: 09/08/2014, 07:20

... of 6 to stratif y the data using a cut-off of 50 years. Although there were more than enough individuals for additional stratification at younger ages, additional str atification at older ages ... designed the study, interpreted the data, and drafted the manuscript; KNA also conducted the analysis. MBK, JTB, RSH, RJB, MAH made substantial contributions to the design of the...

Ngày tải lên: 10/08/2014, 05:21

... anxiety” . The severity of each symptom was coded by 0 = no symptom/mild symptom severity, and 1 = moderate to strong symptom severity. The severity rating depends on the intensity and duration ... Assessing psychopathological symptoms is relatively easy for the trained psychiatrist and represents a clinical standard. Further, psychopathological syndromes are quantitatively measurable...

Ngày tải lên: 11/08/2014, 15:22

... both the lung (airways and parenchyma) and the systemic circulation [32-34]. The intensity of the inflammatory process in the airways and in the systemic circulation is associated with severity ... susceptibil- ity of women to cigarette smoke are largely unknown. There is now a general consensus that inflammation is at the heart of the pathobiology of COPD and that the inf...

Ngày tải lên: 12/08/2014, 16:20