Báo cáo y học: "beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL" pdf

... purposes) Retrovirology Open Access Short report beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL Mingjie Zhang 1 , Qingsheng Huang 1 , Yong Huang 1 , Owen Wood 1 , Weishi Yuan 1 , ... Zidovudine (AZT) synergistically inhibited HIV-1 replication in pri- mary placental macrophages, possibly explaining why AZT can inhibit maternal fetal...

Ngày tải lên: 13/08/2014, 05:21

... subfamily of the cytoch- rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro- limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the k...

Ngày tải lên: 26/10/2012, 09:32

... spectrum of congenital abnormalities evaluated, the period of study (only at birth or in early neonatal period or prenatal or the whole infant period are included), the completeness of ascertainment, ... pregnancies are frequently terminated if the fetus is severely affected. Thus, the rate of defects is calculated for informative offspring including (i) live born in...

Ngày tải lên: 02/11/2012, 11:12

... germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following ... studies have indicated that exogenous DNA becomes concentrated within the posterior part of the nuclear area of the head, the inference being that binding of DNA by the...

Ngày tải lên: 03/11/2012, 10:01

... pasted into the structural alignment. The alignment was then corrected by hand. Since the sequences of the two arginases and agmatinase greately differ in the N terminal region, the agmatinase ... deletions in the agmatinase sequence were modelled using the DGLOOP set of options in WHATIF ; the whole loops and the two connecting amino acids at the beginning and...

Ngày tải lên: 21/02/2014, 01:21

... H A -hydrogen of IPP. In both cases, scrambling of the label takes place within the IPP pool and the error is then transcribed into the DMAPP pool by the normal action of the isomerase. The validity of the proposed ... Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthase from Claviceps, the first pathway-sp...

Ngày tải lên: 22/02/2014, 07:20

... was used. Discussion The most significant finding from our study was that in RA the use in an ELISA of fragments of the intact CII molecule, particularly CB10, as antigen markedly increased the sen- sitivity of ... was markedly increased, from 24% to 88%, comparing the fre- quency using the intact CII molecule; this was not at the expense of the specificity, which...

Ngày tải lên: 09/08/2014, 01:23

... with the goal of optimizing pul- monary function. Physiotherapy, including incentive spirometry, should be continued in the postoperative period. Limitations of the study Thepresentstudyshouldbeinterpretedinthelightof some ... injury of the branches of the internal mammary artery during dissection [21,23], trauma to the phrenic nerve during sternotomy [24] and internal j...

Ngày tải lên: 10/08/2014, 09:21

... carcinoma of the lung was first described in a study conducted by Brambilla in 1992, which analyzed the ultrastructural features of basaloid carcinoma of the lung [4]. Of the 38 cases analyz ed, ... pneumonectomy, lobectomy, segmentectomy) has no bearing on the prog- nosis of BC and PDSC patients [8]. Differences between the findings in this study and other researc...

Ngày tải lên: 10/08/2014, 09:23

... it unlikely that any of the tested SNPs is already an important functional variant. The new associations may instead indicate the effects of physically closely related variants in these genes ... sun light exposure in Caucasians. The evidence that the human CYP2R1 is a key vitamin D 25-hydoxylase is rather new [34] where the identity of the hepatic 25-hydroxylase has r...

Ngày tải lên: 12/08/2014, 16:20