Báo cáo y học: " A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction" ppt

... behaved essentially the same as the pseudotypes bearing the T271I mutant Envs in the entry assay (Fig. 3A and 3B), in the syncytial assay, the Δ2N mutant Envs showed a marked reduction in syncytia ... following in vivo replication of mutant virus [87]. These data suggest that the predicted N- link glycosylation sites at N269 and N342 are critical for maintaini...

Ngày tải lên: 13/08/2014, 05:21

... statistical analysis, and drafted the manuscript. SRR participated in the design of the study and helped to draft the manuscript. AFGB conceived of the study, and participated in its design and coordination ... de los Andes. Carrera 1E No. 19ª14 Bogotá, Colombia Full list of author information is available at the end of the article Abstract Background: In nature, b...

Ngày tải lên: 13/08/2014, 16:20

... dimerization; and basal rates of synthesis and degradation of the receptors. With suitable choices of the parameters, good agreement with a variety of experimental data of the LH release pattern in ... channels increases at a linear rate of v 2 = 0.002 min -1 and has a max- imum value of 1. Thus, immediately a five minute pulse of 5 nM GnRH, 10% of the ch...

Ngày tải lên: 13/08/2014, 22:22

... array data available and generates alternative splicing hypotheses, which can be further validated by experimental studies. Published: 07 April 2006 Theoretical Biology and Medical Modelling ... material Acknowledgements The authors thank Harvard and MIT researchers for allowing us to use their microarray data for this paper. This work was supported by grants from the National Insti...

Ngày tải lên: 13/08/2014, 23:20

... amplification 8 5 (AAAAA, AA), (AAABB, AB), (AABBB, AB), (BBBBB, BB) 5n unbalanced amplification 9 6 (AAAAAA, AA), (AAAAAB, AB), (ABBBBB, AB), (BBBBBB, BB) 6n unbalanced amplification 10 6 (AAAAAA, AA), ... (B, AB), (B, BB) Hemizygous deletion 3 2 (AAAA, AA), (AAAB, AB), (ABBB, AB), (BBBB, BB) Normal 4 3 (AAA, AA), (AAB, AB), (ABB, AB), (BBB, BB) Single copy duplication 5 4 (AAAA, AA), (AAA...

Ngày tải lên: 09/08/2014, 22:23

... thank Yael Berstein and Yonina Eldar for advice on sta- tistical analysis and mathematical formulations. This work was supported by the Mallat Family Fund granted to YMG. HDE was supported by the ... in a software pack- age called Splicing Factor Finder (SFF), which is available in Additional data file 4 as a standalone download suitable for running under the Linux OS. Abbre...

Ngày tải lên: 14/08/2014, 21:20

... 2002 A single charged surface residue modifies the activity of ikitoxin, a beta-type Na + channel toxin from Parabuthus transvaalicus A. Bora Inceoglu 1, *, Yuki Hayashida 2 , Jozsef Lango 3 , Andrew ... Both toxins are active against mice when administered intracerebroventricularly. Mass determination indicated an apparent mass of 6615 Da for ikitoxin vs. 6543 Da for birtoxin...

Ngày tải lên: 31/03/2014, 08:20

... with aA-crystallin and Hsp27 [45] indicate that the dimeric building block of many a- Hsp proteins is formed by interacting bstrands in the a- crystallin domain. Although this may also apply to the ... C-terminal regions and analyzed them by gel filtration, citrate synthase assay and coaffinity purification. Truncation of more than the initial few amino acids of the N-terminal...

Ngày tải lên: 31/03/2014, 21:21

... appear to play key roles in the pathogenesis of RA, and the co-ordinated production of chemokines and proinflammatory cytokines is probably important in the orchestration of the inflammatory responses ... ultraviolet transillumination. Statistical analysis Data were analyzed on a Power Macintosh computer using a statistical software package (Statview 4.5; Abacus Concept...

Ngày tải lên: 09/08/2014, 01:21

... study, we attempted to evaluate the role of the Fas cell-death pathway in the pathogenesis of CIA by generat- ing DBA/1J mice with a mutation of the Fas gene (DBA-lpr/ lpr) and by examining the ... cytokines in joints Since cytokines such as TNF-α and IL-6 are critical media- tors of inflammation, we investigated the effect of Fas on the expression of proinflam...

Ngày tải lên: 09/08/2014, 01:23